Electrochemical Studies of the Neuraminidase Inhibitor Zanamivir and its Voltammetric Determination in Spiked Urine

Skrzypek, Sławomira

doi:10.1002/elan.201000163

Cited by 18 publications

(14 citation statements)

References 25 publications

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“…This analysis was based on the reduction of the nitro group present in the pesticide structure. Recently, our attention focused on the application of catalytic hydrogen evolution (CHE) in the presence of compounds with guanidine group in their structure to their determination in various matrices (Mirceski et al 2005;Skrzypek et al 2009;Skrzypek 2010). As a continuation of our previous study, the aim of the present work was to investigate the voltammetric behavior of CLT based on the catalytic hydrogen evolution in the presence of guanidine group included in the pesticide structure and to elaborate a rapid, simple, and sufficiently sensitive electrochemical method for the determination of this compound in tap water, apple juice, and soil samples.…”

Section: Introductionmentioning

confidence: 99%

Application of Catalytic Hydrogen Evolution in the Presence of Neonicotinoid Insecticide Clothianidin

2011

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Clothianidin, a new generation of pesticide, was determined in spiked tap water, apple juice, and soil by square-wave adsorptive stripping voltammetry. The method of determination is based on the hydrogen evolution reaction catalyzed by clothianidin at the hanging mercury drop electrode. The optimal signal was detected at −1.4 V versus Ag/AgCl in citrate buffer at pH 2.2. Various parameters such as pH, buffer concentration, frequency, amplitude, step potential, accumulation time, and potential were investigated to enhance the sensitivity of the determination. The optimal results were recorded at an accumulation potential of −0.35 V, accumulation time of 7 s, amplitude of 100 mV, frequency of 200 Hz, and step potential of 7 mV. The mechanism of catalytic hydrogen evolution was considered under experimental and theoretical conditions. This electroanalytical procedure enabled to determine clothianidin in the concentration range 9×10 −9 -4×10 −6 mol L −1 in supporting electrolyte and tap water, 1×10 −7 -4×10 −6 mol L −1 in diluted apple juice, and 2× 10 −7 -1×10 −6 mol L −1 in soil. The detection and quantification limits in supporting electrolyte and diluted apple juice were found to be 2.6×10 −9 , 8.6×10 −9 and 3×10 −8 , and 1×10 −7 mol L −1 , respectively. A standard addition method was successfully used to determine clothianidin in spiked tap water, spiked apple juice, and spiked soil.

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Section: Introductionmentioning

confidence: 99%

Application of Catalytic Hydrogen Evolution in the Presence of Neonicotinoid Insecticide Clothianidin

2011

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“…Moroxydine belongs to guanidino compounds and the presence of the guanidine group in its structure potentially gives the possibility for the catalytic hydrogen evolution reaction at the hanging mercury drop electrode. This property was observed for other guanidine compounds such as famotidine [8][9], metformin [10], ganciclovir [11], and zanamivir [12] under conditions of square wave voltammetry, which was the basis for adsorptive catalytic voltammetric determinations at the HMDE. HMDEs are particularly useful due to their high sensitivity, reproducibility and linearity.…”

Section: Introductionmentioning

confidence: 82%

Electrochemical Study of Moroxydine and its Voltammetric Determination with a Silver Amalgam Film Electrode

Skrzypek

2011

Electroanalysis

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Moroxydine (Mor.) is an antiviral agent of biguanide structure. The paper presents a new silver amalgam film electrode (Hg(Ag)FE) for determination of Mor. in phosphate buffer, pH 6.À8 mol L À1 ) and in spiked urine using square wave adsorptive stripping voltammetry. It was found that the compound can act as an electrocatalyst not only at hanging mercury drop electrode but also at the Hg(Ag)FE. The electrode mechanism is connected with the hydrogen evolution reaction catalyzed by moroxydine. Adsorption of moroxydine at the mercury electrode was studied and special arrangements of molecules enabling electron transfer of the protonated form of moroxydine is suggested.

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“…22,26 Skrzypek proposed that Zanamivir as a guanidino compound is adsorbed at mercury surface and catalyzed the reduction of H + to H 2 , resulting in the reduction peak at ¹1.35 V (vs. Ag/AgCl) at mercury electrodes. 22,26 On the other hand, adsorption of Zanamivir in this present work was conducted at gold based electrodes at a normal pH, considering its application for enzyme detection. Apparently, the presence of Zanamivir prevents the redox reaction of gold surface and reduces the peak currents of gold oxidation and reduction.…”

Section: Electrochemical Behavior Of Zanamivirmentioning

confidence: 99%

“…Zanamivir was reported to act as the electrocatalyst for hydrogen reduction at mercury drop electrode, therefore, indirect electrochemical detection of NA can be performed. 22 In this study, the indirect electrochemical detection of NA was developed based on Zanamivir inhibition against NA using Au-BDD electrode, to avoid the use of mercury. Linear calibration curve can be achieved as the presence of Zanamivir inhibits the oxidation of gold electrodes.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Behavior of Zanamivir at Gold-Modified Boron-Doped Diamond Electrodes for an Application in Neuraminidase Sensing

et al. 2015

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This study emphasizes the electrochemical detection of Neuraminidase (NA) based on NA inhibition by Zanamivir. The detection method was developed based on the difference of electrochemical responses of Zanamivir in the presence and the absence of NA in phosphate buffer solution (pH 5.5). Gold and gold-modified boron-doped diamond was used as the working electrode and the measurement was conducted using cyclic voltammetry method. A linear calibration curve of Zanamivir was observed in the concentration range of 5 × 10−4 mol/L (R 2 = 0.991), with the estimated limit of detection (LOD) of 1.49 × 10 −6 mol/L. The presence of NA increases the peak current of gold oxidation and reduction with linear calibration curves were monitored in the concentration range of 0-15 mU (R 2 = 0.996). An estimated LOD of 0.25 mU NA and an excellent reproducibility of the detection with an RSD of 1.18% can be achieved. Application of a real sample was successfully demonstrated for NA detection in the presence of mucin, suggested that the method is promising for pharmaceutical or medical application.

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Electrochemical Studies of the Neuraminidase Inhibitor Zanamivir and its Voltammetric Determination in Spiked Urine

Cited by 18 publications

References 25 publications

Application of Catalytic Hydrogen Evolution in the Presence of Neonicotinoid Insecticide Clothianidin

Application of Catalytic Hydrogen Evolution in the Presence of Neonicotinoid Insecticide Clothianidin

Electrochemical Study of Moroxydine and its Voltammetric Determination with a Silver Amalgam Film Electrode

Electrochemical Behavior of Zanamivir at Gold-Modified Boron-Doped Diamond Electrodes for an Application in Neuraminidase Sensing

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