Electrochemical Thermospray Mass Spectrometry Instrumentation for Coupling Electrochemistry to Mass Spectrometry

Hambitzer, G.; Heitbaum, J.; Stassen, I.

doi:10.1021/ac970753c

Cited by 27 publications

(28 citation statements)

References 8 publications

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“…From an EC perspective, the recent ECaMS reports have focused on the investigation of cell designs, while from a MS perspective, the work has in part explored the bene®t of the newer interfacesaionization sources. For example, Hambitzer and co-workers [16,17] have made use of a thin-layer cell design, in which the counter electrode is isolated from the¯ow stream, coupled online with TS-MS to reexamine the oxidation of N ,N -dialkylanilines. Brajter-Toth and co-workers [18,19] have also explored the use of thin-layer cell on-line with TS-MS and PB-MS. Their new emphasis on the use of thin-layer cell designs, compared to¯ow through designs employing porous electrodes, was motivated in part by the more easy access to the working electrode for cleaning or modi®cation.…”

Section: Introductionmentioning

confidence: 99%

A Thin-Layer Electrochemical Flow Cell Coupled On-Line with Electrospray-Mass Spectrometry for the Study of Biological Redox Reactions

Deng

Berkel²

1999

Electroanalysis

107

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A three electrode thin-layer,¯ow-by electrode cell was coupled on-line with electrospray-mass spectrometry (i.e., ECaES-MS) for the study of biological redox reactions. The cell made use of a commercially available 6.0 mm diameter, offset glassy carbon disk working electrode, a AgaAgCl reference electrode, and a workingacounter electrode spacing gasket (16 mm), along with a home-built PEEK counter electrode block with a Pt foil (7.0 mm wide) counter electrode (cell volume ca. 1.1 mL). Off-line hydrodynamic voltammetry experiments and electrolytic conversion ef®ciency measurements using chronocoulometry were used to characterize the performance of the cell. On-line ECaES-MS conversion ef®ciency was found consistent with the off-line results and the ECaES-MS response time was measured as 5.1 s at a¯ow rate of 30 mLamin and 2.4 s at 62 mLamin. The use of this hybrid system for the study of the products of biologically relevant redox reactions was demonstrated using the oxidation of dopamine in aqueous CH 3 OH (pH 4.0) as a test case. Tandem mass spectrometry experiments provided evidence to conclude that the structure of the two major dopamine oxidation products observed in the ES mass spectra were 5,6-dihydroxyindoline and 5,6-hydroxyindole. Reaction of oxidized dopamine with the surrogate biogenic nucleophile benzene thiol resulted in the formation of mono-, di-, and tri-benzene thiol addition products. These spectra also indicated that the reaction of oxidized dopamine with benzene thiol was signi®cantly faster than the intermolecular cyclization reaction of this intermediate, which normally produces 5,6-dihydroxyindoline.

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Section: Introductionmentioning

confidence: 99%

A Thin-Layer Electrochemical Flow Cell Coupled On-Line with Electrospray-Mass Spectrometry for the Study of Biological Redox Reactions

Deng

Berkel²

1999

Electroanalysis

107

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“…In several articles hyphenation of a thin-layer electrochemical cell with thermospray MS [111] and particle beam MS [112] was shown. Electrochemical system with two tubular Pt electrodes coupled with electrospray MS was used to study the anodic oxidation of metal-diethyldithiocarbamate complexes [113].…”

Section: Hyphenated Electroanalytical Flow Methodsmentioning

confidence: 99%

Electroanalytical Flow Measurements–Recent Advances

2003

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As general trends in current development of chemical analysis, including electroanalysis, one can indicate a search for methods fast and multianalyte, for miniaturized measuring devices, mechanization and automation of analytical processes. In all these trends a significant role is played by measurements in flow conditions. The major advantage of flow electroanalysis is a possibility of utilizing a kinetic discrimination in potentiometric measurements and enhancement of mass transport in voltammetric techniques. Flow injection techniques provide shortening of time of a single analytical determination due to reproducible use of transient signal from the detector without need of obtaining a steady-state equilibrium signal. Electrochemical detection in HPLC gives often improved selectivity and detection limit for electroactive solutes, whereas in capillary electrophoresis it allows a convenient design of portable, integrated chips for field application. This review presents state-of-the -art of flow electroanalysis based on 226 cited literature references

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“…Hambitzer and co-workers re-visited electrochemistry-mass spectrometry for investigation of the anodic oxidation of aniline in dilute sulfuric acid [67,68] and of N,N-dialkylanilines in neutral aqueous solution [69,70,71]. The use of a dual-beam thermospray ion source enabled the study of reactions in non-aqueous solutions.…”

Section: Redox Reactions In Additional Electrochemical Cellsmentioning

confidence: 99%

On-line electrochemistry – MS and related techniques

Diehl

Kärst

2002

Anal Bioanal Chem

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This review summarizes publications on the on-line coupling of electrochemistry with mass spectrometry. After a brief historic introduction it is divided into three parts, organized in order of increasing complexity of the experimental arrangement. The first section deals with the use of the electrospray ion source as an electrochemical reactor for oxidation or reduction reactions. It is followed by the second part which covers the hyphenation of different kinds of electrochemical flow cell with a variety of ionization interfaces. The last section focuses on the on-line coupling of chromatographic techniques with electrochemical flow cells and mass spectrometry.

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Electrochemical Thermospray Mass Spectrometry Instrumentation for Coupling Electrochemistry to Mass Spectrometry

Cited by 27 publications

References 8 publications

A Thin-Layer Electrochemical Flow Cell Coupled On-Line with Electrospray-Mass Spectrometry for the Study of Biological Redox Reactions

A Thin-Layer Electrochemical Flow Cell Coupled On-Line with Electrospray-Mass Spectrometry for the Study of Biological Redox Reactions

Electroanalytical Flow Measurements–Recent Advances

On-line electrochemistry – MS and related techniques

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