Abstract-The Fenton process is one of the most powerful advanced electrochemical processes based on the production of hydroxyl radicals (OH . ) as a result of the reaction of hydrogen peroxide (H 2 O 2 ) with catalyst ferrous ions (Fe 2+ ) under acidic conditions. In this study, tissue paper wastewater with the initial COD concentration of 1200 mg/L was treated using Electro-Fenton method. The cylindrical iron electrochemical reactor was used as a cathode. The turbine impeller with 8 flat blades were used as an anode. The effects of initial pH, current density and concentration of H 2 O 2 on COD removal efficiency were determined. The removal efficiency of 80 % were obtained after 60 minutes of electro-fenton process at the current density of 20 mA/cm 2 with the addition of 0.1M H 2 O 2. Additionally, the electrical energy consumptions were also evaluated. It can be concluded from the study that reactor designed dissimilar from those in the literature, can be used successfully for COD removal from the tissue paper industry wastewater.Index Terms-Tissue paper wastewater, electro-fenton, wastewater treatment, COD.