Electrochemically fabricated polyaniline nanowire-modified electrode for voltammetric detection of DNA hybridization

Zhu, Ning; Zhu, Chen; He, Pingang; Fang, Yuzhi

doi:10.1016/j.electacta.2005.10.038

Cited by 139 publications

(68 citation statements)

References 16 publications

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“…The authors report that they expect to achieve an even lower detection limit by optimizing the nanotube surface area. PAni nanowires can also be synthesised electrochemically, and subsequently modified with oligonucleotides via EDC coupling between phosphate groups and the amino groups of PAni (126). Using this method the complimentary DNA target could be detected down to a concentration of 1 x 10 -12 mol/L.…”

Section: Cp-electrochemical Sensorsmentioning

confidence: 98%

The increasing importance of carbon nanotubes and nanostructured conducting polymers in biosensors

et al. 2010

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The growing needs for analytical devices requiring smaller sample volumes, decreased power consumption and improved performance have been driving forces behind the rapid growth in nanomaterials research. Due to their dimensions, nanostructured materials display unique properties not traditionally observed in bulk materials. Characteristics such as increased surface area along with enhanced electrical/optical properties make them suitable for numerous applications such as nanoelectronics, photovoltaics and chemical/biological sensing. In this review we examine the potential that exists to use nanostructured materials for biosensor devices.By incorporating nanomaterials, it is possible to achieve enhanced sensitivity, an improved response time and smaller size. Here we report some of the success that has been achieved in this area. Many nanoparticle and nanofibre geometries are particularly relevant, in this paper however we specifically focus on organic nanostructures, reviewing conducting polymer nanostructures and carbon nanotubes.

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Section: Cp-electrochemical Sensorsmentioning

confidence: 98%

The increasing importance of carbon nanotubes and nanostructured conducting polymers in biosensors

et al. 2010

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“…The sensors were thus fabricated by an array of gold electrodes and a cross immobilization of DNA strands. In this aspect, polyaniline nanowires were found to be the good substrates for DNA attachment (Chang et al 2007;Zhu et al 2006). Conducting polymer nanowirebased sensor of glassy carbon electrode in an electrolyte solution of aniline could directly assemble through electrochemical layer-by-layer deposition protocol.…”

Section: Indium Oxide (In 2 O 3 ) Nanowiresmentioning

confidence: 99%

Engineered multifunctional nanowires as novel biosensing tools for highly sensitive detection

et al. 2012

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Advances in semiconductive nanowires with novel electronic and optical properties contribute towards new detection methods and revolutionize the way of biosensing. Owing to the large amount of literature pertaining to nanowires (indium oxide, polymer, silicon, and gold), the consequent proposal highlights the research published to feature ultra-sensitive handy biosensors. The focus of this article is the effective evaluation of the outstanding scientific challenges in one-dimensional nanostructures (nanowires) towards innovative and exceptional prospects in designing and fabrication of excellent primary transducers/sensors.

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“…Furthermore, magnetic nanoparticles can be applied to carry the analytes to the transduction platform in microfluidic systems enabling simultaneous detection of different analytes (Konry et al, 2012) or to transport drugs or genes (Dobson, 2006;Kami et al, 2011), or for magnetic resonance imaging (Sun et al, 2008). Nanowires, with the characteristics of low weight with extraordinary mechanical, electrical, thermal, and multifunctional properties, have also been widely used in numerous bio-sensing applications (Curreli et al, 2005;Laocharoensuk et al, 2007;Roberts and Kelley, 2007;Shi et al, 2005;Wanekaya et al, 2006;Zhu et al, 2006). For example, some metal nanowires can be adopted in the detection of glucose (Cusma et al, 2007;Lu et al, 2007;Qu et al, 2007), cholesterol (Aravamudhan et al, 2007a;2007b), or DNA (Gao et al, 2007;Yi et al, 2010).…”

Section: Molecular Targets and Biomarker Sensingmentioning

confidence: 99%

Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers

Zhang

Wang

Khalili

et al. 2016

OMICS: A Journal of Integrative Biology

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We live in exciting times for a new generation of biomarkers being enabled by advances in the design and use of biomaterials for medical and clinical applications, from nano-to macro-materials, and protein to tissue. Key challenges arise, however, due to both scientific complexity and compatibility of the interface of biology and engineered materials. The linking of mechanisms across scales by using a materials science approach to provide structure-process-property relations characterizes the emerging field of 'materiomics,' which offers enormous promise to provide the hitherto missing tools for biomaterial development for clinical diagnostics and the next generation biomarker applications towards personal health monitoring. Put in other words, the emerging field of materiomics represents an essentially systematic approach to the investigation of biological material systems, integrating natural functions and processes with traditional materials science perspectives. Here we outline how materiomics provides a game-changing technology platform for disruptive innovation in biomaterial science to enable the design of tailored and functional biomaterials-particularly, the design and screening of DNA aptamers for targeting biomarkers related to oral diseases and oral health monitoring. Rigorous and complementary computational modeling and experimental techniques will provide an efficient means to develop new clinical technologies in silico, greatly accelerating the translation of materiomics-driven oral health diagnostics from concept to practice in the clinic.

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Electrochemically fabricated polyaniline nanowire-modified electrode for voltammetric detection of DNA hybridization

Cited by 139 publications

References 16 publications

The increasing importance of carbon nanotubes and nanostructured conducting polymers in biosensors

The increasing importance of carbon nanotubes and nanostructured conducting polymers in biosensors

Engineered multifunctional nanowires as novel biosensing tools for highly sensitive detection

Materiomics for Oral Disease Diagnostics and Personal Health Monitoring: Designer Biomaterials for the Next Generation Biomarkers

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