Electrochemiluminescence from Single Molecule to Imaging

Infrared photoinduced electrochemiluminescence microscopy of single cells

“…[25][26][27][28] To pursue the quest for higher sensitivity, single photons and single biomolecules were imaged at the level of cells, organelles or bacteria by developing original approaches and specically tailored nanomaterials. [29][30][31] Feng and co-workers reported a direct optical method for imaging single ECL photons generated by individual electron-transfer reaction events in solution. 32 They extended their original approach to image cells and nanoparticles with remarkable optical resolution.…”

Sub-Second Electrochemiluminescence Imaging Assay of SARS-CoV-2 Nucleocapsid Protein Based on Reticulation of Endo-Coreactants

“…Electrochemiluminescence (ECL) imageology already shines brightly in metaproteomic target discovery and diagnostics, 1,2 which technically hinge on its edge of electron multipliable and expedited emission at pixel-level resolution. 3 One paragon is the FDA-certified gold standard for polyfactorial bioassays, the MesoScale microplate-reading platform. 4 Its neat retrofit via as much as 4 × 384-well rasterization enables high-content visual screening on hundreds of trace samples with exceptional precision and parallelism.…”

Electrogenerated chemiluminescence at boron-doped diamond electrodes

“…9 The latter comprises the development of new luminophores such as inorganic complexes 10,11 or organic molecules, 12 either freely diffusing in solution or embedded within nanosystems, [13][14][15][16][17] and ECL imaging with spatial and temporal resolution for the investigation of reaction mechanisms, [18][19][20][21][22][23][24][25][26] and biological applications. [27][28][29][30][31][32][33][34] Because ECL is primarily triggered by a heterogeneous electrochemical reaction, electrode materials are crucial in the signal development and intensity, and this subject was already reviewed for common electrode materials. 35 Here, we focus our attention on doped diamonds, as special electrode materials with their own peculiarities, for application in electrochemiluminescence.…”