Electrochemistry and structural properties of new mixed ligand nickel(<scp>ii</scp>) complexes based on thiosemicarbazone

Güveli, Şükriye; Koca, Atıf; Özdemir, Namık; Bal‐Demirci, Tülay; Ülküseven, Bahrı

doi:10.1039/c4nj00556b

Cited by 23 publications

(10 citation statements)

References 42 publications

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“…The infrared spectra of the ligands, clearly showed the vibrations of OH, N 4 H, N 2 H, and C@N 1 groups in accordance with the data of similar thiosemicarbazones [7,16,21,22]. In the spectra of and L 2 H 2 ) bands are absent as a result of the deprotonation of the ligands.…”

Section: Synthesis and Spectral Studiessupporting

confidence: 82%

“…The electrochemical parameters indicate irreversible redox processes having relatively high negative potential values compared with similar thiosemicarbazone ligands [22,30,32], probably because of the six carbon number (is relatively high) substituent on the N 4 -nitrogen. Complexes 1-3 gave metal based reduction and oxidation processes in addition to the redox of the free ligands.…”

Section: Resultsmentioning

confidence: 97%

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Spectroscopic, electrochemical and X-ray diffraction studies on nickel(II)-complexes of acetophenone thiosemicarbazones substituted six-carbon groups

Güveli

Özdemir

Koca

et al. 2016

Inorganica Chimica Acta

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Section: Synthesis and Spectral Studiessupporting

confidence: 82%

Section: Resultsmentioning

confidence: 97%

Spectroscopic, electrochemical and X-ray diffraction studies on nickel(II)-complexes of acetophenone thiosemicarbazones substituted six-carbon groups

Güveli

Özdemir

Koca

et al. 2016

Inorganica Chimica Acta

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“…Thiosemicarbazone based metal complexes have remarkable biological activities such as antitumor, 1-3 antiviral, 4,5 antibacterial, 6 antioxidant, 7-9 antidiabetic 10 properties and different coordination structures [11][12][13][14][15][16][17][18] . The biological properties of thiosemicarbazone are often related to metal ion coordination.…”

Section: Introductionmentioning

confidence: 99%

Iron(iii) and nickel(ii) complexes as potential anticancer agents: synthesis, physicochemical and structural properties, cytotoxic activity and DNA interactions

et al. 2015

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Template reactions of 2-hydroxy-R-benzaldehyde-S-methylisothiosemicarbazones (R= 3methoxy or 4-hydroxy) with the corresponding aldehydes in the presence of FeCl 3 and NiCl 2 yielded N 1 ,N 4 -disalicylidene chelate complexes. The compounds were characterized by means of elemental and spectroscopic methods. The structure of complex 1 was determined by x-ray single crystal diffraction. Crystal data (Mo Kα; 296 K) are as follows: monoclinic space group P2 1 /c, a = 12.9857(8) Å, b = 7.8019(4) Å, c = 19.1976(12) Å, β = 101.655(5)°, Z = 4. Cytotoxic effects of the compounds were evaluated by MTT assay in K562 leukemia, ECV304 endothelial and normal mononuclear cells and DNA fragmentation analysis using the diphenylamine reaction were performed. The DNA binding capacity of thiosemicarbazones at IC 50 and different concentrations was investigated. The DNA fragmentation percentage of compound treated cells were higher than non-treated control cells but compound 3 (84%) was higher than the others. The interaction of compounds 1-4 and DNA was investigated voltammetrically by using nucleic acids modified electrodes after the double stranded fish sperm DNA (fsDNA), or poly (dA).poly (dT) was immobilized onto the surface of pencil graphite electrodes (PGEs). Accordingly, the oxidation signals of DNA bases; guanine and adenine were measured by using differential pulse voltammetry (DPV). The changes at the signals of guanine and adenine were evaluated before and after interaction process. The results indicated compound 3 was cytotoxic in very low concentrations in K562 leukemia cells unlike other cells and that could damage the DNA double stranded form, specifically the adenine base. Therefore, it may be a selective antileukemic effect and drug potential.thiosemicarbazones. Generally, the transition metals play a very important role in an organism and their complexes can interact non-covalently with nucleic acid by intercalation, groove-binding or external electrostatic binding for cations. 3,7,[19][20][21][22] There have been numerous studies in the literature investigating drug-DNA interactions by using conventional techniques such as HPLC, GC, and mass spectrometry. Considering the numerous advantages of electrochemical analysis techniques, the disadvantages of these conventional techniques arising from their complicated form of analysis have made them less preferable. Since the electroactivity of nucleic acids was discovered in the 1960s, 29 electrochemical nucleic acid biosensors, known as electrochemical genosensors, have frequently been preferred for recognition of (bio)molecule-DNA interactions. There are several research articles that investigated (bio)molecule-DNA interaction by using electrochemical techniques in the literature. [30][31][32][33][34][35][36] PGEs bring some crucial properties such as being robust, single-use, practical and having a large surface area. Their combination with electrochemical detection techniques provides fast, practical, accurate and time-saving analysis of target analytes. Moreover, th...

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“…The complexes of Ni(II) have been studied continuously for its biological activities [68][69][70][71][72][73][74][75] and attracted the attention of researchers to develop and design such more these complexes [76]. Various Ni(II) complexes with thiosemicarbazide and semicarbazide moiety [77][78][79][80] have been reported with increased antioxidant [81], anticancer [82], antiproliferative activities [83,84], antimicrobial [85], antibacterial [86], etc.…”

Section: Biological Importance Of Semicarbazones and Thiosemicarbazonesmentioning

confidence: 99%

Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

Jain¹,

Kumar²,

Chandra³

2018

Asian J. Chem.

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Electrochemistry and structural properties of new mixed ligand nickel(ii) complexes based on thiosemicarbazone

Cited by 23 publications

References 42 publications

Spectroscopic, electrochemical and X-ray diffraction studies on nickel(II)-complexes of acetophenone thiosemicarbazones substituted six-carbon groups

Spectroscopic, electrochemical and X-ray diffraction studies on nickel(II)-complexes of acetophenone thiosemicarbazones substituted six-carbon groups

Iron(iii) and nickel(ii) complexes as potential anticancer agents: synthesis, physicochemical and structural properties, cytotoxic activity and DNA interactions

Biological Applications of Co(II) and Ni(II) Complexes of Semicarbazones and Thiosemicarbazones

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