Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

Radi, Abd-Elgawad

doi:10.2174/1875038901003010074

Cited by 32 publications

(8 citation statements)

References 116 publications

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“…This plot shows that the aqueous solubility of the drug increases linearly as a function of α -cyclodextrin concentration. It is clearly observed that the solubility diagram of Tamoxifen citrate in the presence of α -cyclodextrin can be classified as the A L type 10 . The linear host guest correlation with slope of less than 1 suggested the formation of a 1:1 complex (Tamoxifen citrate: α -cyclodextrin) with respect to α -CD concentrations.…”

Section: Phase Solubility Studymentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:The objective of the present investigation is to study the possibilities to improve the aqueous solubility and dissolution rate of Tamoxifen citrate (TC) -an oral anticancer drug, based on inclusion complexes with -cyclodextrin (α -CD). The inclusion processes are discussed based on absorption, emission, FT-IR, 1 H-NMR, SEM and phase solubility study. The α -CD study shows that the drug form 1:1 inclusion complexes. The solubility and dissolution results revealed that there was a considerable increase in solubility and dissolution of all inclusion complexes. Scanning Electron Microscopy (SEM) to analyze physicochemical interaction between drug and carrier and evaluation of the crystal morphology and their approximate size. The inclusion complex appears as tiny aggrigates of amorphous pieces of irregular sizes. In both absorption and emission the intensity increase with increase in concentration of α -CD. The aromatic ring is encapsulated in the non-popular α -CD cavity. The formation constant value reveals a hydrogen bonding interaction is present between the drug and α -CD cavity. The presence of aliphatic chains has not significantly changed the absorption and emission spectral behaviour and inclusion process. INTRODUCTION:Tamoxifen Citrate is an antagonist of the estrogen receptor in breast tissue via its active metabolite. In other tissues such as the endometrium, it characterized as a mixed agonist/ antagonist. Tamoxifen citrate is the usual endocrine (anti-estrogen) therapy for hormone receptor positive breast cancer in pre-menopausal women and is also a standard in post-menopausal women although aromators, inhibitors are also frequently used in that setting.

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Section: Phase Solubility Studymentioning

confidence: 99%

Untitled

2016

IJPSR

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“…The ability of inclusion complex formation is mainly due to the thermodynamics of the process [9] and possible non-covalent interactions (NCI) between the ligand and the CD cavity [10]. Thermodynamically, the inclusion process is guided by the inclusion constant (𝐾 𝑖 ), entropy (∆𝑆), enthalpy (∆𝐻), and Gibbs free energy of reaction (∆𝐺) [11,12,13], in addition to the non-covalent interactions between the ligand and the cavity [10,14].…”

Section: Introductionmentioning

confidence: 99%

THERMODYNAMIC AND REACTIVITY ASPECT OF β-CYCLODEXTRINE INCLUSION COMPLEXES WITH COUMARIN DERIVATIVES

González

Espinoza

2022

J. Chil. Chem. Soc.

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In this study, the thermodynamic and reactivity characteristics of coumarin-derived ligand inclusion complexes with βCD were described, in addition to the in situ reactivity of these ligands and their changes in the complex cavity. For this purpose, computational tools such as molecular docking, second order perturbative analysis (E2PERT), ONIOM2 (DFT/PM6) methods were employed to obtain the global and local reactivity indices, and thermodynamic parameters, in addition to noncovalent interaction (NCI) analysis. As a result, it can be observed that the inclusion complexes are stable and viable given the ability to form non-covalent interactions, but their formation is not spontaneous under the modeling conditions. The global and local reactivity indices show that the ligands change their chemical reactivity inside the inclusion complex, demonstrating that the studied ligands present AOX SET activity outside the cavity, and HAT activity inside the cavity, mainly the C1 and C3 ligands.

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“…Cyclodextrins (CDs) are toroidal-shaped, biocompatible, relatively non-toxic, cyclic oligomers [ 16 ]. In aqueous solutions, CDs can incorporate geometrically and polarity-compatible target compounds to improve their stability [ 17 ], increase their solubility [ 18 ], and enhance their bioavailability [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…In aqueous solutions, CDs can incorporate geometrically and polarity-compatible target compounds to improve their stability [ 17 ], increase their solubility [ 18 ], and enhance their bioavailability [ 19 ]. This increases the applicability of CDs in many fields, including pharmaceutics [ 16 , 20 ], cosmetics [ 17 ], and food technology [ 21 , 22 ]. Therefore, many researchers have deemed CDs as potential specific drug carriers or nano-inclusion agents with the ability to reduce the toxicity of target compounds, after numerous modifications [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

Davaatseren

Hong

et al. 2017

Molecules

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trans-Cinnamaldehyde (tCIN), an active compound found in cinnamon, is well known for its antioxidant, anticancer, and anti-inflammatory activities. The β-cyclodextrin (β-CD) oligomer has been used for a variety of applications in nanotechnology, including pharmaceutical and cosmetic applications. Here, we aimed to evaluate the anti-inflammatory and antioxidant effects of tCIN self-included in β-CD complexes (CIs) in lipopolysaccharide (LPS)-treated murine RAW 264.7 macrophages. RAW 264.7 macrophages were treated with increasing concentrations of β-CD, tCIN, or CIs for different times. β-CD alone did not affect the production of nitric oxide (NO) or reactive oxygen species (ROS). However, both tCIN and CI significantly reduced NO and ROS production. Thus, CIs may have strong anti-inflammatory and antioxidant effects, similar to those of tCIN when used alone.

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Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

Cited by 32 publications

References 116 publications

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THERMODYNAMIC AND REACTIVITY ASPECT OF β-CYCLODEXTRINE INCLUSION COMPLEXES WITH COUMARIN DERIVATIVES

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

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Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

Cited by 32 publications

References 116 publications

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THERMODYNAMIC AND REACTIVITY ASPECT OF &#946;-CYCLODEXTRINE INCLUSION COMPLEXES WITH COUMARIN DERIVATIVES

Studies on the Anti-Oxidative Function of trans-Cinnamaldehyde-Included β-Cyclodextrin Complex

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THERMODYNAMIC AND REACTIVITY ASPECT OF β-CYCLODEXTRINE INCLUSION COMPLEXES WITH COUMARIN DERIVATIVES