Electrochemistry ofNAD(P)⁺/NAD(P)H

Abstract

The sections in this article are Introduction NAD ( P ) + / NAD ( P ) in Living Systems Formal Potential of the NAD + / NADH Redox Couple Focus and Scope of the Chapter Direct Electrochemical Oxidation of NAD ( P ) H General Observations Effect of Adsorption Mechanism and Kinetics Homogeneous Oxidation of NAD ( P ) H by Oxidizing Redox Compounds One‐electron No‐proton Acceptors Two‐electron‐proton Acceptors o ‐quinones and p ‐quinones Aromatic Diimines Electrocatalytic Oxidation of NAD ( P ) H at Mediator‐modified Electrodes General Remarks of CMEs o ‐Quinones and Phenylenediimine Derivatives Other Mediating Functionalities and Metal‐coated Electrodes Catalytic NADH Oxidation at CMEs Based on Polymers Mechanistic and Kinetic Aspects CMEs Based on NADH ‐oxidizing Enzymes Amperometric Biosensors Based on NAD ( P )‐dependent Dehydrogenase Enzymes Direct Electrochemical Reduction of NAD ( P ) + General Observations Adsorption Phenomena Mechanism and Kinetics Electrocatalytic Reduction of NAD ( P ) + Nonenzymatic Electroreduction of NAD ( P ) + Enzymatic Electroreduction of NAD ( P ) + Acknowledgment

Electrochemical oxidation of dihydronicotinamide adenine dinucleotide (NADH): comparison of highly oriented pyrolytic graphite (HOPG) and polycrystalline boron-doped diamond (pBDD) electrodes

“…5,17,18 Electrode surface modification has been considered as a means of achieving an effective decrease in overpotential for NADH oxidation. 19,20 However, studies of unmodified electrodes are valuable both to provide a benchmark and to seek the optimal electrode format. The electrochemistry of NADH at conducting diamond has received attention, but the focus has mainly been on hydrogen-terminated diamond, 15,21 with oxygen terminated diamond 14 receiving only scant attention.…”

Regeneration of the NADH Cofactor by a Rhodium Complex Immobilized on Multi-Walled Carbon Nanotubes

“…1 The efficient in situ regeneration of NADH from NAD + is valuable in biocatalysis due to the stoichiometric amount required for NADHdependent enzymes along with its relatively high cost. 1 It was reported that the combination of three NAD + -dependent dehydrogenases (formate dehydrogenase, formaldehyde dehydrogenase and alcohol dehydrogenase) is capable of generating methanol from CO 2 by reversing the original enzymatic reaction direction. [2][3][4][5] In this enzyme cascade, one molecule of methanol is produced at the cost of three equivalents of NADH.…”

Amperometric L‐Lactate Biosensor Based on Gold Nanoparticles

“…A convenient way to decrease the high overpotential and avoid fouling effect is to use suitable mediators that can facilitate the electron transfer kinetics. In this way, much effort has been made to identify/develop new materials that can effectively overcome the kinetic barriers for the electrochemical regeneration of NAD þ [35]. Nevertheless, such electrodes possess certain drawbacks, such as leaching of mediator and lack of long-term stability, which may limit their analytical application [36].…”