“…Diverse shapes of micro- and nanofluidic channels have been studied for various applications, such as biological testing, , clinical diagnosis, , environmental analysis, drug synthesis, , and energy generation. , In particular, curved (arc on xy -plane) microfluidic channels have been extensively investigated since they increase the effective channel length per unit chip length in the flow direction. Simultaneously, a curved microchannel induces a centrifugal force that drives a transverse secondary flow (Dean vortices), which plays a crucial role in cell separation, fluid mixing, and target particle trapping. − Unlike the micro one, the curved nanochannel exhibits several distinctive properties because of its small feature size, such as higher energy conversion, molecular interaction, and ion transportation . Furthermore, if the channel cross-section is circular instead of the common rectangular one in most micro- and nanofluidic channels, it can eliminate the corner effect that creates nonuniform pressure distributions at the corners of the channel .…”