Electrochemotherapy of Mycosis fungoides by interferon-α

New Modality for Electrochemotherapy of Surface Tumors

“…this pulse sequence has been optimized during long series of clinical tests with companion animals (20,21,22) and human patients and was implemented in a family of instruments currently used in the medical practice (14,16).…”

The Role of Electrochemotherapy in the Treatment of Malignant Melanoma

“…ECT with injection of TNF-α intra or peritumorally and suboptimal doses of Bleomycin in mice might have a positive immunomodulatory effect, and possibly adds a systemic component to the localized ECT treatment 120 . It has been noted that EP with INF-α used to treat Mycosis Fungoides (subcutaneous lymphoma) lesions produced a 100 % CR 121 The cytotoxic action of INF-α was attributed to its increased tumoral concentration and the prolonged time of action produced by the EP. ECT either with INF-α or TNF-α might permit the usage of less toxic doses, while enhancing clinical local and systemic immunological response rates and minimizing systemic side effects 19 .…”

Treatment of Melanoma by Electroporation of Bacillus Calmette-Guerin

“…After the first application of electrical pulses for effective introducing of anticancer drugs (6), electrochemotherapy could be considering as an established method for treatment of malignant cutaneous and subcutaneous tumours (7). The efficiency of the electrochemotherapy of skin tumors was confirmed in several clinical trials (5,13,16,18). electrochemotherapy of multiple melanoma malignim with intravenous application of bleomycin seems to be a good adjuvant therapy for unresectable cases.…”

“…Applications of electrochemotherapy not only with cytostatic drugs, like bleomycin and cisplatin, but also with factors that influence upon the immune system, such as interferon-α, were reported (12).…”