Electrocortical evidence for an early abnormal processing of panic-related words in panic disorder patients

Pauli, Paul; Amrhein, Christine; Mühlberger, Andreas; Dengler, Wilhelm; Wiedemann, Georg

doi:10.1016/j.ijpsycho.2005.01.009

Cited by 50 publications

(30 citation statements)

References 25 publications

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“…P1 enhancement to negative stimuli may reflect rapid threat evaluation processes mediated by primitive affective systems (Cacioppo & Gardner, 1999;van Hooff, et al, 2008;Vuilleumier, 2005), including reentrant projections from the amygdala to sensory cortices (Pizzagalli, Regard, & Lehmann, 1999), which are hypersensitive in anxiety (Holmes, Nielsen, & Green, 2008). As with previous studies, P1 was not generally enhanced to negative stimuli in HCs (Bar-Haim, et al, 2005;Junghöfer, et al, 2001;Olofsson & Polich, 2007;Qin & Han, 2009;Thomas, et al, 2007) or in PD (Pauli, Amrhein, Mühlberger, Dengler, & Wiedemann, 2005;Pauli, et al, 1997;Windmann, et al, 2002).…”

Section: Attentional Biases To Threatmentioning

confidence: 57%

Neural time course of threat-related attentional bias and interference in panic and obsessive–compulsive disorders

Thomas

Gonsalvez

Johnstone

2013

Biological Psychology

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Attentional biases to threat are considered central to anxiety disorders, however physiological evidence of their nature and time course is lacking. Event-related potentials (ERPs) characterized sensory and cognitive changes while 20 outpatients with panic disorder (PD), 20 with obsessive-compulsive disorder (OCD), and 20 healthy controls (HCs) responded to the color (emotional Stroop task) or meaning of threatening and neutral stimuli. ERPs indicated larger P1 amplitude and longer N1 latency in OCD, and shorter P1 latency in PD, to threatening (versus neutral) stimuli, across instructions to attend to, or ignore, threat content. Emotional Stroop interference correlated with phobic anxiety and was significant in PD. Participants with emotional Stroop interference had augmented P1 and P3 amplitudes to threat (versus neutral) stimuli when color-naming. The results suggest early attentional biases to threat in both disorders, with disorder-specific characteristics. ERPs supported preferential early attentional capture and cognitive elaboration hypotheses of emotional Stroop interference.

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Section: Attentional Biases To Threatmentioning

confidence: 57%

Neural time course of threat-related attentional bias and interference in panic and obsessive–compulsive disorders

Thomas

Gonsalvez

Johnstone

2013

Biological Psychology

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“…These results are consistent with cognitive models of panic disorder, assuming that certain bodily sensations are perceived and processed automatically. In another study, the same group showed that panic patients are characterised by an early automatic and elaborated processing of panic-related stimuli (Pauli, Amrhein, Muhlberger, Dengler, & Wiedemann, 2005).…”

Section: Panic Disordermentioning

confidence: 96%

Event-Related Brain Potentials in Psychopathology: Clinical and cognitive perspectives

Hansenne

2006

PSYCHOL BELG

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Since the discovery of the P300 component, a large number of studies have been conducted with the aim to find abnormalities of this psychophysiological marker among the main psychiatric disorders. The first studies were very promising, but successive findings were rather controversial resulting in two main positions (the pros and the cons) as regard to the usefulness of P300 in clinical psychopathology. However, P300 studies provide interesting findings concerning information processing in psychopathology. Moreover, other Event-Related Potentials (ERPs), such as the Mismatch Negativity (MMN) and the Error-Related Negativity (ERN) are particularly interesting for the study of cognitive processes in psychopathology. In this review, the author will give an overview of the main findings of P300, MMN and ERN values in psychopathology from a clinical and a cognitive point of view. After a brief description of the rationale of ERPs, the findings in schizophrenia, depression, alcoholism, posttraumatic stress disorder, panic disorder, and obsessive-compulsive disorder will be sequentially reviewed. The diagnostic usefulness of P300 in psychopathology is limited, but could be increased if variables known to influence P300 amplitude or latency are controlled. Doubtless, grouping two or more different ERP components would greatly improve the usefulness of the clinical applications of brain potentials. On the other hand, a growing number of studies have provided evidence of the relevance of ERPs to investigate cognitive processes in psychopathology.

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“…Typical changes in the amplitude/ time parameters of a "classic" ERP, the P300 wave, were observed in the case of high-anxiety/phobic disorders [6,7].…”

Section: Introductionmentioning

confidence: 98%

Reflection of Anxiety in the Characteristics of Evoked EEG Potentials in 10- to 11-Year-Old Children

2009

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We studied the peculiarities of the amplitude/time parameters of evoked EEG potentials (EPs) and event-related potentials (ERPs) in 10-to 11-year-old children characterized by low and high anxiety levels. The latter levels were estimated using the scale of the manifest anxiety test of Prikhozhan and projective techniques ("HouseTree-Person," HTP, and the Lüscher color test). For children with a high anxiety level, the amplitudes of the following EP components and ERPs were lower than those in low-anxiety children of the same age: P1 (predominantly in the occipital region of the left hemisphere), P2 (in the right occipital region), and Р300 wave (in different loci of both hemispheres). In high-anxiety children, we also more frequently observed increased amplitudes of the N2 component in the left parietal and right occipital regions. High-anxiety individuals were characterized by longer latencies of component P1 (mostly in the right frontal and left central regions) and, at the same time, shorter latencies of component N1 (in the parietal and occipital regions of the left hemisphere and also in the right temporal region). Thus, we found that the amplitude/time characteristics of a few EP components and ERPs in children with high anxiety levels differ statistically significantly from the parameters of corresponding EPs/ERPs in individuals of the same age but with low anxiety levels.

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Electrocortical evidence for an early abnormal processing of panic-related words in panic disorder patients

Cited by 50 publications

References 25 publications

Neural time course of threat-related attentional bias and interference in panic and obsessive–compulsive disorders

Neural time course of threat-related attentional bias and interference in panic and obsessive–compulsive disorders

Event-Related Brain Potentials in Psychopathology: Clinical and cognitive perspectives

Reflection of Anxiety in the Characteristics of Evoked EEG Potentials in 10- to 11-Year-Old Children

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