Electrocorticographic changes in field potentials following natural somatosensory percepts in humans

Kramer, Daniel R.; Barbaro, Michael F.; Lee, Morgan; Peng, Terrance; Nune, George; Liu, Charles Y.; Kellis, Spencer; Lee, Brian

doi:10.1007/s00221-019-05495-1

Cited by 9 publications

(7 citation statements)

References 51 publications

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“…Human fMRI studies suggest disruption in the central executive network (active at external task demands) and the default mode network (active at wakeful rest) in patients with delirium. Both networks involve the prefrontal cortex 74,114 and are consistent with the network dysconnectivity hypothesis of delirium. 87,89 These regionspecific hypotheses for delirium could be tested in animal models with direct neurophysiological recording; however, unlike EEG, the low temporal resolution of most types of brain imaging require that the animal be motionless for long periods, implying the use of anesthetics, which could confound the results.…”

Section: Functional Magnetic Resonance Imagingsupporting

confidence: 75%

“…Direct, more invasive neurophysiological activities, such as local field potentials, single neuron activity, and brain microdialysis (directly measuring neurotransmitter levels), could provide critical insights into the neurophysiological mechanisms of delirium. While becoming possible in human cohorts (eg, electrocorticography recordings prior to epilepsy resection and brain‐computer interface studies 114‐118 ), direct neural recordings are primarily applicable only to preclinical animal models. In particular, the brain regions that represent specific cognitive functions or neurotransmitter systems can be directly tested in animal models 87,89 .…”

Section: Introductionmentioning

confidence: 99%

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Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network

Vasunilashorn

Lunardi

Newman

et al. 2023

Alzheimer's & Dementia

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Delirium is a common, morbid, and costly syndrome that is closely linked to Alzheimer's disease (AD) and AD-related dementias (ADRD) as a risk factor and outcome. Human studies of delirium have advanced our knowledge of delirium incidence and prevalence, risk factors, biomarkers, outcomes, prevention, and management. However, understanding of delirium neurobiology remains limited. Preclinical and translational models for delirium, while challenging to develop, could advance our knowledge of delirium neurobiology and inform the development of new prevention and treatment approaches. We discuss the use of preclinical and translational animal models in delirium, focusing on (1) a review of current animal models, (2) challenges and strategies for replicating elements of human delirium in animals, and (3) the utility of biofluid, neurophysiology, and neuroimaging translational markers in animals. We conclude with recommendations for the development and validation of preclinical and translational models for delirium, with the goal of advancing awareness in this important field.

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Section: Functional Magnetic Resonance Imagingsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network

Vasunilashorn

Lunardi

Newman

et al. 2023

Alzheimer's & Dementia

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“…Others reported that low gamma ERS (40-60 Hz) often started at or after grasp onset and could last longer than the movements, suggesting that it may be linked to a combination of movement execution and sensory feedback related modulations (Crone et al, 1998;Szurhaj et al, 2005). Together with phasic response of fast adapting receptors, it is likely that the fast firings generated by the slowly adapting Ruffini endings and Merkel cells contribute to the early high-intensity broadband gamma response that we observed ( Figure 5) by way of skin deformation, indentation, as well as pressure at the onset of the grasp (Roudaut et al, 2012;Ryun et al, 2017b;Delhaye et al, 2018;Kramer et al, 2019). The broadband high-frequency ERS later reduces to a low-intensity gamma response at a lower frequency as time progresses and this behavior can be related to the activation patterns of the slowly adapting receptors of the afferent system (Roudaut et al, 2012;Delhaye et al, 2018).…”

Section: Connections To the Dynamics Of The Afferent Systemmentioning

confidence: 84%

“…Others also briefly mentioned the presence of biphasic peaks of ERS in human ECoG during hand grasp (Flint et al, 2017). Interestingly, recent work on the response to deep, light and soft touch (Kramer et al, 2019) with ECoG showed that elevations in HG power seen within selected electrodes over the hand area of primary somatosensory cortex (S1), lasted between around 300 and 500 ms, but extinguished prior to the end of the tactile stimulus. This coincides with our findings regarding the S1 high-gamma attenuation pattern during the hold period of a grasp task and Figure 3 shows that high-intensity gamma response (50-150 Hz) peaked between 50 and 400 ms after grasp onset, within selected electrodes anterior and posterior to the central sulcus.…”

Section: Temporal Dynamics Of Lfb-erd and Hfb-ersmentioning

confidence: 99%

Power Modulations of ECoG Alpha/Beta and Gamma Bands Correlate With Time-Derivative of Force During Hand Grasp

et al. 2020

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It is well-known that motor cortical oscillatory components are modulated in their amplitude during voluntary and imagined movements. These patterns have been used to develop brain-machine interfaces (BMI) which focused mostly on movement kinematics. In contrast, there have been only a few studies on the relation between brain oscillatory activity and the control of force, in particular, grasping force, which is of primary importance for common daily activities. In this study, we recorded intraoperative high-density electrocorticography (ECoG) from the sensorimotor cortex of four patients while they executed a voluntary isometric hand grasp following verbal instruction. The grasp was held for 2 to 3 s before being instructed to relax. We studied the power modulations of neural oscillations during the whole time-course of the grasp (onset, hold, and offset phases). Phasic event-related desynchronization (ERD) in the low-frequency band (LFB) from 8 to 32 Hz and event-related synchronization (ERS) in the high-frequency band (HFB) from 60 to 200 Hz were observed at grasp onset and offset. However, during the grasp holding period, the magnitude of LFB-ERD and HFB-ERS decreased near or at the baseline level. Overall, LFB-ERD and HFB-ERS show phasic characteristics related to the changes of grasp force (onset/offset) in all four patients. More precisely, the fluctuations of HFB-ERS primarily, and of LFB-ERD to a lesser extent, correlated with the time-course of the first time-derivative of force (yank), rather than with force itself. To the best of our knowledge, this is the first study that establishes such a correlation. These results have fundamental implications for the decoding of grasp in brain oscillatory activity-based neuroprosthetics.

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“…Investigators suggest that eye closure-related alpha augmentation is correlated to functional idling of cortical areas. 2,3,37 Task-related alpha attenuation has been reported to be temporarily coupled with high-gamma augmentation in many iEEG studies of motor, 15,75,76 somatosensory, 77,78 visual, 16,17,79,80 auditory, 81,82 memory, 83,84 and language function. [85][86][87][88] Investigators suggest that task-related high-gamma augmentation is more accurately time-locked to a given behavior and spatially more confined to the eloquent cortex.…”

Section: Significance Of Functional Connectivity Modulationsmentioning

confidence: 99%

Dynamic cortical and tractography atlases of proactive and reactive alpha and high-gamma activities

Ono

Sonoda

Sakakura

et al. 2022

Preprint

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Alpha waves - posterior-dominant rhythms at 8-12 Hz reactive to eye opening and closure - are among the most fundamental EEG findings in clinical practice and research since Hans Berger first documented them in the early 20th century. Yet, the exact network dynamics of alpha waves in regard to eye movements remains unknown. High-gamma activity at 70-110 Hz is also reactive to eye movements and a summary measure of local cortical activation supporting sensorimotor or cognitive function. We aimed to build the first-ever brain atlases directly visualizing the network dynamics of eye movement-related alpha and high-gamma modulations, at cortical and white matter levels. We studied 28 patients (age: 5-20 years) who underwent intracranial EEG and electrooculography recordings. We measured alpha and high-gamma modulations at 2,170 electrode sites outside the seizure onset zone, interictal spike-generating areas, and MRI-visible structural lesions. Dynamic tractography animated white matter streamlines modulated significantly and simultaneously beyond chance, on a millisecond scale. Before eye closure onset, significant alpha augmentation occurred at the occipital and frontal cortices. After eye closure onset, alpha-based functional connectivity was strengthened, while high gamma-based connectivity was weakened extensively in both intrahemispheric and interhemispheric pathways involving the central visual areas. The inferior fronto-occipital fasciculus supported the strengthened alpha coaugmentation-based functional connectivity between occipital and frontal lobe regions, whereas the posterior corpus callosum supported the interhemispheric functional connectivity between the occipital lobes. After eye opening offset, significant high gamma augmentation and alpha attenuation occurred at occipital, fusiform, and inferior parietal cortices. High gamma coaugmentation-based functional connectivity was strengthened, whereas alpha-based connectivity was weakened in the posterior interhemispheric and intrahemispheric white matter pathways involving central and peripheral visual areas. Proactive and reactive alpha waves involve extensive, distinct white matter networks that include the frontal lobe cortices, along with low- and high-order visual areas. High-gamma co-attenuation coupled to alpha co-augmentation in shared brain circuitry after eye closure supports the notion of an idling role for alpha waves during eye closure. These dynamic tractography atlases may improve understanding of the significance of EEG alpha waves in assessing the functional integrity of brain networks in clinical practice; they also may help elucidate the effects of eye movements on task-related brain network measures observed in cognitive neuroscience research.

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Electrocorticographic changes in field potentials following natural somatosensory percepts in humans

Cited by 9 publications

References 51 publications

Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network

Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network

Power Modulations of ECoG Alpha/Beta and Gamma Bands Correlate With Time-Derivative of Force During Hand Grasp

Dynamic cortical and tractography atlases of proactive and reactive alpha and high-gamma activities

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