Electrodeposited conducting polymer PEDOT doped with pure carbon nanotubes for the detection of dopamine in the presence of ascorbic acid

Xu, Guogang; Li, Beibei; Cui, Xinyan Tracy; Ling, Luyang; Liu, Xiang

doi:10.1016/j.snb.2013.07.038

Cited by 94 publications

(65 citation statements)

References 30 publications

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“…Poly(3,4-ethylenedioxythiophene) (PEDOT) has been coated extensively on biosensors to improve sensor function or biocompatibility. [65] Luo group used PEDOT doped CNT [66] and PEDOT doped graphene [67] coated GC electrodes for the detection of dopamine. The authors stated PEDOT catalyzed the electrochemical reaction of dopamine, but gave no specific mechanism for the catalytic effect of PEDOT to dopamine.…”

Section: 0 Neurotransmitters/neurochemicalsmentioning

confidence: 99%

Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review

Yang

Denno

Pyakurel

et al. 2015

Analytica Chimica Acta

494

263

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Carbon nanomaterials are advantageous for electrochemical sensors because they increase the electroactive surface area, enhance electron transfer, and promote adsorption of molecules. Carbon nanotubes (CNTs) have been incorporated into electrochemical sensors for biomolecules and strategies have included the traditional dip coating and drop casting methods, direct growth of CNTs on electrodes and the use of CNT fibers and yarns made exclusively of CNTs. Recent research has also focused on utilizing many new types of carbon nanomaterials beyond CNTs. Forms of graphene are now increasingly popular for sensors including reduced graphene oxide, carbon nanohorns, graphene nanofoams, graphene nanorods, and graphene nanoflowers. In this review, we compare different carbon nanomaterial strategies for creating electrochemical sensors for biomolecules. Analytes covered include neurotransmitters and neurochemicals, such as dopamine, ascorbic acid, and serotonin; hydrogen peroxide; proteins, such as biomarkers; and DNA. The review also addresses enzyme-based electrodes that are used to detect non-electroactive species such as glucose, alcohols, and proteins. Finally, we analyze some of the future directions for the field, pointing out gaps in fundamental understanding of electron transfer to carbon nanomaterials and the need for more practical implementation of sensors.

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Section: 0 Neurotransmitters/neurochemicalsmentioning

confidence: 99%

Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review

Yang

Denno

Pyakurel

et al. 2015

Analytica Chimica Acta

494

263

View full text Add to dashboard Cite

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“…However, the oxidation potential of DA commonly appears similar to that of AA, 50 therefore, various materials have been selected and modified on the surface of the electrode in order to simultaneously detect DA and AA, such as metal nanoparticles, 51 graphene, 52 carbon nanotubes, 53 polymers, 54 or their composite materials. [55][56][57] Herein, we investigated the application of the PILs/PPyNTs modified GCE as an electrochemical sensor for the simultaneous determination of DA and AA. The electrochemical behaviour of the PILs/PPyNTs modified GCE was compared with the pristine PPyNTs modified GCE and the bare GCE which acted as the blank under the exact same conditions.…”

Section: Morphology and Characterization Of Pils/ppyntsmentioning

confidence: 99%

Preparation of poly(ionic liquids)-functionalized polypyrrole nanotubes and their electrocatalytic application to simultaneously determine dopamine and ascorbic acid

et al. 2015

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Novel poly(ionic liquids) functionalized polypyrrole nanotubes (PILs/PPyNTs) were successfully synthesized.1-Vinyl-3-ethylimidazole bromide (VEIB) was polymerized on the surface of novel polymerizable vinyl imidazolium-type IL modified PPyNTs prepared by a covalent method. Due to the modification of PILs, the dispersibility of PILs/PPyNTs in aqueous solution was significantly improved and their surface charge properties were obviously changed to electropositivity. Because of the synergetic effects of conductive PPyNTs and biocompatible PILs, excellent electrochemical catalytic activities towards dopamine (DA) and ascorbic acid (AA) were achieved using a PILs/PPyNTs modified glassy carbon electrode (GCE), which gave a large potential difference enough to well distinguish DA from AA, with excellent sensitivity and good stability, for the simultaneous detection of DA and AA. The existence of PILs effectively improved the transmission mode of electrons of DA and AA oxidation on the electrode and resulted in their different electrocatalytic performance.

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“…Poly(3,4-ethylene dioxythiophene) (PEDOT) is electro-polymerized from 3,4-ethylene dioxythiophene (EDOT) monomers. The oxidative polymerization of PEDOT results in positive charges on the polymer backbone, this allows for the incorporation of negatively charged doping agents, such as graphene oxide (GO) (Luo et al 2013a; Wang et al 2015; Wang et al 2014; Weaver et al 2014a; Weaver et al 2014b), polystyrene sulfonate (PSS) (Alemu et al 2012; Tait et al 2013), carbon nanotubes (CNT) (Gerwig et al 2012; Luo et al 2011; Xu et al 2013), Nafion (Vreeland et al 2015; Wang and Olbricht 2010) and tosylate (Larsen et al 2012; Vreeland et al 2014), for the purpose of charge balancing. The introduction of a doping agent also has the added benefit of incorporating additional reactive functional groups.…”

Section: Introductionmentioning

confidence: 99%

Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes

Taylor

Robbins

Catt

et al. 2017

Biosensors and Bioelectronics

Self Cite

179

113

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Dopamine (DA) is a monoamine neurotransmitter responsible for regulating a variety of vital life functions. In vivo detection of DA poses a challenge due to the low concentration and high speed of physiological signaling. Fast scan cyclic voltammetry at carbon fiber microelectrodes (CFEs) is an effective method to monitor real-time in vivo DA signaling, however the sensitivity is somewhat limited. Electrodeposition of poly(3,4-ethylene dioxythiophene) (PEDOT)/graphene oxide (GO) onto the CFE surface is shown to increase the sensitivity and lower the limit of detection for DA compared to bare CFEs. Thicker PEDOT/GO coatings demonstrate higher sensitivities for DA, but display the negative drawback of slow adsorption and electron transfer kinetics. The moderate thickness resulting from 25 s electrodeposition of PEDOT/GO produces the optimal electrode, exhibiting an 880% increase in sensitivity, a 50% decrease in limit of detection and minimally altered electrode kinetics. PEDOT/GO coated electrodes rapidly and robustly detect DA, both in solution and in the rat dorsal striatum. This increase in DA sensitivity is likely due to increasing the electrode surface area with a PEDOT/GO coating and improved adsorption of DA’s oxidation product (DA-o-quinone). Increasing DA sensitivity without compromising electrode kinetics is expected to significantly improve our understanding of the DA function in vivo.

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Electrodeposited conducting polymer PEDOT doped with pure carbon nanotubes for the detection of dopamine in the presence of ascorbic acid

Cited by 94 publications

References 30 publications

Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review

Recent trends in carbon nanomaterial-based electrochemical sensors for biomolecules: A review

Preparation of poly(ionic liquids)-functionalized polypyrrole nanotubes and their electrocatalytic application to simultaneously determine dopamine and ascorbic acid

Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes

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