Electroencephalographic Activity and Cognitive Function in Middle-Aged Patients with Obstructive Sleep Apnea Before and After Continuous Positive Airway Pressure Treatment

Wang, Jianhua; Xu, Juan; Liu, Shilin; Han, Fei; Wang, Qiaojun; Gui, Hao; Chen, Rui

doi:10.2147/nss.s322426

Cited by 10 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First of all, MoCA is the classic and the most commonly used test to identify the cognitive impairment, and the total score of MoCA and its sub-categories, attention and delayed recall, were statistically different. Consistent with the results of previous studies, the MoCA score of the OSA group was lower than that without OSA, especially in severe OSA group, suggesting that the degree of cognitive impairment in OSA is related to the severity of the disease ( 28 , 29 ). The sub-categories of MoCA, attention and delayed recall, were mostly influenced.…”

Section: Discussionsupporting

confidence: 91%

Performance of the Activities and Participation component of International Classification of Functioning, Disability and Health Sleep Disorders Brief Core Set in patients with obstructive sleep apnea

Huang¹,

Wang²,

Wu³

et al. 2023

J Thorac Dis

View full text Add to dashboard Cite

Background Limitation of daily activities and impairment of working memory have received less attention in the clinical diagnosis and prognostic assessment of obstructive sleep apnea (OSA). In this study, the Activities and Participation component of the International Classification of Functioning, Disability and Health (ICF) Sleep Disorders Brief Core Set was evaluated for its performance in predicting impaired work ability in OSA patients. Methods A total of 221 subjects were recruited into this cross-sectional study. ICF Sleep Disorders Brief Core Set, polysomnography, and neuropsychological tests were applied for data acquisition. Data analysis was performed by regression analysis and receiver operating characteristic (ROC) construction. Results The scores for the component Activities and Participation were significantly different between the no OSA/OSA group, and were elevated as the severity of OSA increased. Scores were positively correlated with apnea-hypopnea index (AHI), trail making test (TMT), and negatively correlated with symbol digit modalities test (SDMT) correct. The component Activities and Participation performed better with the threshold of 4 in the prediction of impaired attention and work ability in severe OSA [AHI ≥30 events/h, bottom 10% of TMT part B (TMTb) scores as the diagnostic criteria], with area under the curve, sensitivity and specificity as 0.909, 71.43% and 96.72%, respectively. Conclusions The Activities and Participation component of the ICF Sleep Disorders Brief Core Set could have the potential to predict the impairment of attention and work ability in OSA patients. It provides a new perspective for the identification of OSA patients’ disturbances in daily activities and improving the overall assessment level.

show abstract

Section: Discussionsupporting

confidence: 91%

Performance of the Activities and Participation component of International Classification of Functioning, Disability and Health Sleep Disorders Brief Core Set in patients with obstructive sleep apnea

Huang¹,

Wang²,

Wu³

et al. 2023

J Thorac Dis

View full text Add to dashboard Cite

show abstract

“…Mullins et al found that in patients with OSA, greater REM sleep EEG slowing was associated with reduced vigilance on PVT and more crashes on a driving simulator (Mullins, Kim et al, 2020b). EEG slowing across the total night (including multiple NREM and REM sleep cycles) in patients with OSA did not predict cognition via the MMSE or MoCA (Wang et al, 2021). Further analyses are needed to assess whether NREM‐ or REM‐specific slowing have differing impacts on cognition in OSA.…”

Section: Eeg Measures Of Sleep Microstructure In Osamentioning

confidence: 99%

Sleep electroencephalography biomarkers of cognition in obstructive sleep apnea

Gagnon

Kamińska

2023

Journal of Sleep Research

View full text Add to dashboard Cite

SummaryObstructive sleep apnea has been associated with cognitive impairment and may be linked to disorders of cognitive function. These associations may be a result of intermittent hypoxaemia, sleep fragmentation and changes in sleep microstructure in obstructive sleep apnea. Current clinical metrics of obstructive sleep apnea, such as the apnea–hypopnea index, are poor predictors of cognitive outcomes in obstructive sleep apnea. Sleep microstructure features, which can be identified on sleep electroencephalography of traditional overnight polysomnography, are increasingly being characterized in obstructive sleep apnea and may better predict cognitive outcomes. Here, we summarize the literature on several major sleep electroencephalography features (slow‐wave activity, sleep spindles, K‐complexes, cyclic alternating patterns, rapid eye movement sleep quantitative electroencephalography, odds ratio product) identified in obstructive sleep apnea. We will review the associations between these sleep electroencephalography features and cognition in obstructive sleep apnea, and examine how treatment of obstructive sleep apnea affects these associations. Lastly, evolving technologies in sleep electroencephalography analyses will also be discussed (e.g. high‐density electroencephalography, machine learning) as potential predictors of cognitive function in obstructive sleep apnea.

show abstract

“…Previous studies have shown that sleep EEG abnormalities and cognitive performance in OSA were reversible after 6 months of continuous positive airway pressure treatment. 12,14,33,[47][48][49] Thus, the decrease in PSD observed in our study may have been caused by brain tissue damage due to chronic hypoxia. Designing interventions that directly target EEG biomarkers associated with OSA and/or specific symptom dimensions to improve clinical outcomes is a promising approach.…”

Section: Limitationsmentioning

confidence: 58%

“…32 Six EEG signals (F3-M2, F4-M1, C1-M2, C2-M1, O1-M2, and O2-M1), two channels of electrooculography (EOG) signals (E1-M2, E2-M2), chin EMG (EMG1-EMG2, EMG1-EMG3), electrocardiography (ECG), respiration (nasal pressure, airflow), oxygen saturation (SpO2), abdominal and chest movement, and leg movements were recorded. 33 Due to limitations associated with our collection equipment and technology, we were unable to include the central channel in our analysis.…”

Section: Methodsmentioning

confidence: 99%

EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea

Zhang,

Wang,

et al. 2023

NSS

View full text Add to dashboard Cite

Purpose Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder. Research conducted on patients with OSA using electroencephalography (EEG) has revealed a noticeable shift in the overnight polysomnography (PSG) power spectrum. To better quantify the effects of OSA on brain function and to identify the most reliable predictors of pathological cortical activation, this study quantified the PSG power and its association with the degree of hypoxia in OSA patients. Patients and Methods This retrospective study recruited 93 patients with OSA. OSA patients were divided into three groups based on their apnea-hypopnea index (AHI) scores. The clinical characteristics and sleep macrostructure of these patients were examined, followed by an analysis of PSG signals. Power spectral density (PSD) in five frequency bands was analyzed during nonrapid eye movement (NREM) sleep, rapid eye movement (REM) sleep, and wakefulness. Finally, correlation analysis was conducted to assess the relationships among PSD, PSG parameters, and serum levels of S100β and uric acid. Results Obstructive sleep apnea occurred during both the NREM and REM sleep phases. Except for a decrease in the duration of N2 sleep and an increase in the microarousal index, there were no significant differences in sleep architecture based on disease severity. Compared to the mild OSA group, the theta and alpha band PSD in the frontal and occipital regions during NREM sleep and wakefulness were significantly decreased in the moderate and severe OSA groups. Correlation analysis revealed that theta PSD in N1 and N3 stages were negatively correlated the AHI, oxygen desaturation index, SaO2<90% and microarousal index. Conclusion These findings imply that patients with more severe OSA exhibited considerable NREM hypoxia and abnormal brain activity in the frontal and occipital regions. Therefore, sleep EEG oscillation may be a useful neurophysiological indicator for assessing brain function and disease severity in patients with OSA.

show abstract

Electroencephalographic Activity and Cognitive Function in Middle-Aged Patients with Obstructive Sleep Apnea Before and After Continuous Positive Airway Pressure Treatment

Cited by 10 publications

References 39 publications

Performance of the Activities and Participation component of International Classification of Functioning, Disability and Health Sleep Disorders Brief Core Set in patients with obstructive sleep apnea

Performance of the Activities and Participation component of International Classification of Functioning, Disability and Health Sleep Disorders Brief Core Set in patients with obstructive sleep apnea

Sleep electroencephalography biomarkers of cognition in obstructive sleep apnea

EEG Power Spectral Density in NREM Sleep is Associated with the Degree of Hypoxia in Patients with Obstructive Sleep Apnea

Contact Info

Product

Resources

About