Electroencephalographic Correlates of Increased Platelet Membrane Fluidity in Alzheimer's Disease

Zubenko, George S.; Brenner, Richard P.; Teply, Ivana

doi:10.1001/archneur.1988.00520330099016

Cited by 7 publications

(2 citation statements)

References 54 publications

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“…The 49 demented patients participated in a previously published study of EEG correlates of increased platelet membrane fluidity in Alzheimer's disease. 20 The elderly controls were recruited from advertisements in the media and were typically spouses or caregivers of patients in the Alzheimer's disease group.…”

Section: Methodsmentioning

confidence: 99%

“…In summary, Alzheimer's disease patients with increased platelet membrane fluidity exhibited a decreased prevalence of risk factors for stroke, as well as fewer cases with focal EEG changes, 20 than Alzheimer's disease patients with normal fluidity. The platelet membrane abnormality describes a clinical subgroup of patients with Alzheimer's disease who are less likely to have coexisting occult cerebrovascular disease than the remaining demented patients who meet NINCDS-ADRDA consensus clinical criteria for Alzheimer's disease.…”

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confidence: 88%

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Risk factors for stroke as predictors of platelet membrane fluidity in Alzheimer's disease.

Zubenko

Brenner

Teply

1991

Stroke

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We have previously reported that increased platelet membrane fluidity identifies a subgroup of patients with Alzheimer's disease who have distinct clinical features including an earlier age of symptomatic onset, a more rapidly progressive cognitive decline, and a decreased prevalence of focal electroencephalographic findings. In the current study, these patients also exhibited a decreased prevalence of risk factors for stroke compared with patients who had normal platelet membrane fluidity. Our findings suggest that the platelet membrane abnormality describes a clinical subgroup of patients with Alzheimer's disease who are less likely to have coexisting cerebrovascular disease than the remaining patients who meet clinical consensus criteria for probable Alzheimer's disease. (Stroke 1991;22:997-1003)

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Section: Methodsmentioning

confidence: 99%

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confidence: 88%