Electroencephalographic correlates of the audiogenic seizure response of inbred mice

Maxson, Stephen C.; Cowen, John S.

doi:10.1016/0031-9384(76)90224-9

Cited by 55 publications

(16 citation statements)

References 42 publications

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“…They are categorized as generalized seizures originating in the midbrain and provoked by high-intensity acoustic stimulation [10,11]. Several authors have attempted to identify the anatomical substrate responsible for the genesis and propagation of audiogenic seizures.…”

Section: Introductionmentioning

confidence: 99%

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

Muñoz

Carballosa-Gautam

Yanowsky

et al. 2017

Epilepsy & Behavior

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The hamster has been previously described as a paroxysmal dystonia model, but our strain is currently recognized as a model of audiogenic seizures (AGS). The original first epileptic hamster appeared spontaneously at the University of Valladolid, where it was known as the GPG:Vall line, and was transferred to the University of Salamanca where a new strain was developed, named GASH:Sal. By testing auditory brainstem responses, the GASH:Sal exhibits elevated auditory thresholds that indicate a hearing impairment. Moreover, amplified fragment length polymorphism analysis distinguished genetic differences between the susceptible GASH:Sal hamster strain and the control Syrian hamsters. The GASH:Sal constitutes an experimental model of reflex epilepsy of audiogenic origin derived from an autosomal recessive disorder. Thus, the GASH:Sal exhibits generalized tonic-clonic seizures, characterized by a short latency period after auditory stimulation, followed by wild running, a convulsive phase, and finally stupor, with origin in the brainstem. The seizure profile of the GASH:Sal is similar to those exhibited by other models of inherited AGS susceptibility, which decreases after six months of age, but the proneness across generations is maintained. The GASH:Sal can be considered a reliable model of audiogenic seizures, suitable to investigate current antiepileptic pharmaceutical treatments as well as novel therapeutic drugs.This article is part of a Special Issue entitled Genetic Models-Epilepsy.

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Section: Introductionmentioning

confidence: 99%

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

Muñoz

Carballosa-Gautam

Yanowsky

et al. 2017

Epilepsy & Behavior

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“…Thus, the ability of various mouse strain brain regions to accumulate neurotransmission-related compounds could be precisely compared. The whole brains minus neocortex and cerebellum were employed in this study since audiogenic seizure induction in mice appears to involve solely subcortical mechanisms (18,19). Our data clearly show a major difference in choline uptake by the two mouse strains.…”

Section: Discussionmentioning

confidence: 85%

Seizure proneness and neurotransmitter uptake

1979

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The ability of midbrain homogenates from two strains of mice to accumulate several putative neurotransmitters, or their precursor in the case of acetylcholine, has been examined. The high-affinity transport mechanisms toward glutamate. GABA, dopamine, and glycine were similar in both strains. The seizure-prone DBA/2IBG strain had a significantly higher capacity to transport choline than did the relatively seizure-resistant C57BL/6 IBG mice. However, no difference in the density of muscarinic binding sites in the two mouse strains was found.

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“…In nonkindled rodents, full-blown audiogenic seizures do not usually induce epileptiform activity in the cortex [7,8,30,59,60], confirming the subcortical origin of these seizures. Acutely induced audiogenic seizures of moderate severity (i.e., generalized clonic seizures) are not accompanied by distinct cortical epileptiform activity [30], though the amygdala has been shown to be involved in the network of the clonic form of AS even in nonkindled GEPR-3s [61].…”

Section: Epileptiform Discharge Is a Hallmark Of Secondary Cortical Ementioning

confidence: 90%

Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features

Vinogradova

2017

Epilepsy & Behavior

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Electroencephalographic correlates of the audiogenic seizure response of inbred mice

Cited by 55 publications

References 42 publications

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

The genetic audiogenic seizure hamster from Salamanca: The GASH:Sal

Seizure proneness and neurotransmitter uptake

Audiogenic kindling and secondary subcortico-cortical epileptogenesis: Behavioral correlates and electrographic features

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