Electroencephalographic responses to alcohol challenge in Native American Mission Indians

Ehlers, Cindy L.; Garcia‐Andrade, Consuelo; Wall, Tamara L.; Cloutier, David; Phillips, Evelyn

doi:10.1016/s0006-3223(98)00113-9

Cited by 84 publications

(91 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many test clusters showed an increased proportion of significant drug effects at higher doses ( Table 7). The most convincing dose-response impairments were found for focused attention (7% of the tests within this cluster were impaired in the <0.5 g l -1 level, increasing to 62% at 0.5- Table 5 Tests used more than 10 times [191][192][193][194][195][196][197] (n = 7) EEG beta Electro-encephalography (EEG), Magneto-encephalography (MEG) 9 64 27 [192,193,196,197] (n = 4) EEG delta Electroencephalography (EEG) 0 100 0 [197] (n = 1)…”

Section: Dose-response Relationshipsmentioning

confidence: 92%

Functional biomarkers for the acute effects of alcohol on the central nervous system in healthy volunteers

Zoethout

Delgado

Ippel

et al. 2011

Brit J Clinical Pharma

View full text Add to dashboard Cite

The central nervous system (CNS) effects of acute alcohol administration have been frequently assessed. Such studies often use a wide range of methods to study each of these effects. Unfortunately, the sensitivity of these tests has not completely been ascertained. A literature search was performed to recognize the most useful tests (or biomarkers) for identifying the acute CNS effects of alcohol in healthy volunteers. All tests were grouped in clusters and functional domains. Afterwards, the effect of alcohol administration on these tests was scored as improvement, impairment or as no effect. Furthermore, dose-response relationships were established. A total number of 218 studies, describing 342 different tests (or test variants) were evaluated. Alcohol affected a wide range of CNS domains. Divided attention, focused attention, visuo-motor control and scales of feeling high and of subjective drug effects were identified as the most sensitive functional biomarkers for the acute CNS effects of alcohol. The large number of CNS tests that are used to determine the effects of alcohol interferes with the identification of the most sensitive ones and of drug-response relationships. Our results may be helpful in selecting rational biomarkers for studies investigating the acute CNS effects of alcohol or for future alcohol-interaction studies.

show abstract

Section: Dose-response Relationshipsmentioning

confidence: 92%

Functional biomarkers for the acute effects of alcohol on the central nervous system in healthy volunteers

Zoethout

Delgado

Ippel

et al. 2011

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Third, a low LR to alcohol has been documented in several other groups at high risk for alcohol-related problems using a retrospective self-report measure of the usual number of drinks required for various effects, including studies of Native Americans and Koreans. (Ehlers et al, 1999;GarciaAndrade et al, 1997;Luczak et al, 2002;Wall et al, 1992Wall et al, , 1999. At the same time, one group at relatively low future risk for alcoholism, Jewish subjects, demonstrated a significantly higher intensity of response to alcohol in an alcohol challenge (Monteiro et al, 1991).…”

Section: Introductionmentioning

confidence: 99%

The level of response to alcohol in daughters of alcoholics and controls

Eng

Schuckit

Smith

2005

Drug and Alcohol Dependence

View full text Add to dashboard Cite

Background: The low level of response (LR) to alcohol is a genetically influenced characteristic related to the development of alcohol use disorders (AUDs). This phenotype is found in men with a family history (FH) of alcoholism, predicts future AUDs, and has heritabilities as high as 60%. However, despite evidence of genetic influences for AUDs in both sexes, the majority of studies evaluating differences in LR across high-and low-risk groups have been conducted on males, and it is unclear how generalizable these results are to women. Methods: Twenty-five women who are family history positive (FHP) for alcohol dependence were matched with 25 women with no FH of alcoholism (FHN) on factors that may impact LR. Using an alcohol challenge paradigm, data on the reaction to a moderate dose of alcohol were gathered over a period of 3.5 h. Assessments included breath alcohol concentrations (BrACs), the Subjective High Assessment Scale (SHAS), as well as body sway or static ataxia. Results: Family history positives reported lower subjective intoxication than FHNs. In addition, when body sway scores were corrected for skewness, FHPs had significantly lower scores on alcohol-related changes in lateral sway. These differences remained after considering the effects of drinking history and BrAC values. Conclusions: This study evaluated the LR to alcohol in the largest sample of alcohol challenges in matched FHP and FHN women to date. Overall, the findings are consistent with most data from earlier investigations of smaller sized samples of FHP women. The results suggest that, similar to sons of alcoholics, a low LR to alcohol might also be characteristic of daughters of alcoholics.

show abstract

“…A low level of response to alcohol is more common in both men and women with a first-degree family history of an AUD (Eng et al, 2005;Schuckit and Smith, 1996). This relationship has been found across ethnic groups, including Caucasians, Hispanics, and Native Americans (Ehlers et al, 1999;Schuckit et al, , 2006. The prevalence of a family history of AUDs varies by ethnicity.…”

mentioning

confidence: 98%

Ethnic Differences in Level of Response to Alcohol Between Chinese Americans and Korean Americans

Duranceaux

Schuckit

Luczak

et al. 2008

J. Stud. Alcohol Drugs

View full text Add to dashboard Cite

Objective-Koreans have higher rates of alcohol-use disorders and family history of alcoholism, compared with Chinese. These differences likely reflect both environmental and genetic influences. One genetically influenced characteristic that may contribute to these ethnic differences is level of response to alcohol. Variant alleles of aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH1B) genes are prevalent in individuals of Asian heritage and have been associated with an increased level of response to alcohol and a decreased risk for alcohol dependence. Additionally, a low level of response to alcohol is more common in individuals with a first-degree family history of alcoholism and is predictive of increased risk for this disorder. It also is possible that sociocultural factors have an impact on an individual's response to alcohol. The current study examined self-report level of response to alcohol, ALDH2 and ADH1B, country of origin, and family history of alcoholism in 154 Chinese-and 181 Korean-American college students.Method-Participants were evaluated via in-person interviews and genotyped at the ALDH2 and ADH1B loci.Results-Ethnicity was significantly related to level of response to alcohol, with Koreans having a lower self-reported level of response than Chinese. This relationship remained significant after considering the effects of gender, height, weight, quantity and frequency of alcohol consumption (over the previous 90 days), ALDH2 genotype, ADH1B genotype, country of origin, and first-degree family history of alcohol dependence.

show abstract

Electroencephalographic responses to alcohol challenge in Native American Mission Indians

Cited by 84 publications

References 78 publications

Functional biomarkers for the acute effects of alcohol on the central nervous system in healthy volunteers

Functional biomarkers for the acute effects of alcohol on the central nervous system in healthy volunteers

The level of response to alcohol in daughters of alcoholics and controls

Ethnic Differences in Level of Response to Alcohol Between Chinese Americans and Korean Americans

Contact Info

Product

Resources

About