Electrogenerated chemiluminescence of nanomaterials for bioanalysis

Abstract

Since the electrogenerated chemiluminescence (ECL) of silicon nanoparticles (NPs) was reported in 2002, miscellaneous nanomaterials with various sizes and shapes have been employed as ECL nanoemitters for bioanalysis. Elucidation of the ECL derivation from these nanoemitters and pertinent biofunctionalization with multitudinous biomolecules can offer excellent ECL signal-transduction platforms for fabricating novel biosensing devices. In this review, we comprehensively describe retrospective and recent advances in NPs-based ECL and related biosensing methodologies, and review their analytical applications in the detection of small biological molecules, enzymatic sensing, immunoassay, DNA analysis and cytosensing.

Electrochemiluminescence Detection in Paper‐Based and Other Inexpensive Microfluidic Devices

“…Various nanomaterials have also been demonstrated to produce ECL in similar mechanisms as the molecular luminophores. [22] The fundamental ECL process is Figure 1. Typical ECL process in aqueous solution.…”

Silver nanowires-based signal amplification for CdSe quantum dots electrochemiluminescence immunoassay

“…Electrochemiluminescence (ECL) has grown significantly as a highly sensitive and selective analytical and diagnostic method in recent years (Deng and Ju, 2013). This method covers advantages of controllability from electrochemistry and low background from chemiluminescence (Miao, 2008;Richter, 2004).…”

A Review of Electrogenerated Chemiluminescent Biosensors for Assays in Biological Matrices

“…In addition to enhancing the surface area and catalyzing electron-transfer processes during ECL, some nanomaterials can serve as the luminophore in ECL reactions [23][24][25][26][27][28]. The first report ECL from NPs was for silicon nanocrystal QDs in 2002 [73].…”

“…Many groups have investigated the effects of incorporation of nanomaterials, such as nanoparticles (NPs) and quantum dots (QDs) into biosensors [23][24][25][26][27][28]. The unique mechanical, electrochemical and luminescent properties of nanomaterials have stimulated much research in this area during the past decade.…”