Electrohydrodynamic processing for the production of zein-based microstructures and nanostructures

Silva, Pedro Miguel Peixoto; Torres‐Giner, Sergio; Vicente, A. A.; Cerqueira, Miguel A.

doi:10.1016/j.cocis.2021.101504

Cited by 26 publications

(28 citation statements)

References 62 publications

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“…Zein has good biocompatibility, natural biodegradability, thermal stability, and renewable properties. 99 When used in drug delivery systems, zein can promote wound healing; it is also adopted for the regeneration treatment of muscle, cartilage, and nerve tissues. However, a large number of hydrophobic amino acids lead to the poor cell affinity of zein.…”

Section: Zeinmentioning

confidence: 99%

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Zhao¹,

Chen²,

Feng³

et al. 2022

IJN

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Periodontitis is a major threat to oral health, prompting scientists to continuously study new treatment techniques. The nanofibrous membrane prepared via electrospinning has a large specific surface area and high porosity. On the one hand, electrospun nanofibers can improve the absorption capacity of proteins and promote the expression of specific genes. On the other hand, they can improve cell adhesion properties and prevent fibroblasts from passing through the barrier membrane. Therefore, electrospinning has unique advantages in periodontal treatment. At present, many oral nanofibrous membranes with antibacterial, anti-inflammatory, and tissue regeneration properties have been prepared for periodontal treatment. First, this paper introduces the electrospinning process. Then, the commonly used polymers of electrospun nanofibrous membranes for treating periodontitis are summarized. Finally, different types of nanofibrous membranes prepared via electrospinning for periodontal treatment are presented, and the future evolution of electrospinning to treat periodontitis is described.

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Section: Zeinmentioning

confidence: 99%

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Zhao¹,

Chen²,

Feng³

et al. 2022

IJN

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“…This causes rapid evaporation of the solvent and results in the production of dry micro-and nanofibers or micro-and nanoparticles, respectively, that are deposited on the collector. [11,25,27,29] The electrospinning of polymer-based solutions can be easily obtained using the basic setup. The electrospinning process is conducted in three steps: jet initiation, elongation, and solidification.…”

Section: Ehdp Basicsmentioning

confidence: 99%

“…This causes rapid evaporation of the solvent and results in the production of dry micro‐ and nanofibers or micro‐ and nanoparticles, respectively, that are deposited on the collector. [ 11,25,27,29 ]…”

Section: Ehdp Basicsmentioning

confidence: 99%

“…Operation methods and equipment may vary according to the intended structures and use, but the basic setup is equal for both electrospinning and electrospraying techniques. [12,[25][26][27][28][29] A schematic illustration of the basic setup of EHDP, both for electrospinning and electrospraying, can be seen in Figure 2. A basic setup requires just four components, namely a syringe equipped with a metal capillary (usually a needle-shaped spinneret), a feed pump to feed the polymer solution through the spinneret, a high-voltage power supply (usually applied at the tip of the spinneret), and a grounded collector (of variable morphology) to collect the produced structures.…”

Section: Ehdp Basicsmentioning

confidence: 99%

“…A basic setup requires just four components, namely a syringe equipped with a metal capillary (usually a needle-shaped spinneret), a feed pump to feed the polymer solution through the spinneret, a high-voltage power supply (usually applied at the tip of the spinneret), and a grounded collector (of variable morphology) to collect the produced structures. [12,[25][26][27][28][29] The voltage difference between the spinneret and the grounded collector creates an electrical field that, when the droplet's surface tension is exceeded, draws the polymer solution from the spinneret tip to the grounded collector, either in the shape of fibers (electrospinning) or particles (electrospraying). This causes rapid evaporation of the solvent and results in the production of dry micro-and nanofibers or micro-and nanoparticles, respectively, that are deposited on the collector.…”

Section: Ehdp Basicsmentioning

confidence: 99%

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Management of Operational Parameters and Novel Spinneret Configurations for the Electrohydrodynamic Processing of Functional Polymers

Silva

Torres‐Giner

Vicente

et al. 2022

Macro Materials & Eng

Self Cite

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Functional materials have become key drivers in the development of multiple high‐end technologies. Electrohydrodynamic processing (EHDP) is a straightforward method to generate polymer micro‐ and nanostructures that can be applied to the food, pharmaceutical, environmental, and biomedical areas, among others, since these can yield materials with higher performance. Some of the EHDP's advantages over other polymer processing technologies rely on its high versatility, by which the final assembly can be modified in different ways to combine materials with multiple properties and also in different morphological structures, and the use of room processing conditions, meaning that thermolabile ingredients can be incorporated with minimal activity loss. This review provides the historical background, process basics, and the state‐of‐the‐art of the most recent advances achieved in the EHDP technology dealing with the control of its operational parameters to optimize processability and achieve end‐product quality and homogeneity. It also focuses on the newly developed modes of operation and spinneret configurations that can lead to the formation of a wide range of micro‐ and nanostructures with different functionalities and solve some of its current technical limitations. Finally, it also further highlights the potential applications of the resultant hierarchical functional polymer‐based materials obtained by these novel EHDP methods.

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Fabrication of Zein‐Based Fibrous Scaffolds for Biomedical Applications—A Review

Rahman

Dip

Haase

et al. 2023

Macro Materials & Eng

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Zein, which accounts for around 80% of the total protein composition in corn, is a biocompatible and biodegradable substance derived from renewable sources. Although insoluble in water, its amphiphilic characteristics are utilized to generate nanoparticles, nanofibers, microparticles, and even films. Numerous recent studies have demonstrated the potential of zein as a prospective biomaterial to develop fibrous scaffolds for biomedical functions owing to its biocompatibility, fibrous formation, and encapsulating qualities. Fabrication of zein‐based fibrous scaffolds for biomedical applications is achieved by a wide variety of techniques, including electrospinning, wet spinning, freeze drying, and additive manufacturing. This article overviews current advancements in manufacturing techniques for zein‐based fibrous scaffolds. In addition, it summarizes the most recent biomedical applications and research activities utilizing zein‐based fibrous scaffolds. Overall, zein is proposed as a potential biomaterial for the production of fibrous scaffolds that stimulate cell adhesion and proliferation in a number of exciting biomedical applications due to its biodegradability, biocompatibility, and other unique features related to its structure.

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Electrohydrodynamic processing for the production of zein-based microstructures and nanostructures

Cited by 26 publications

References 62 publications

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Electrospun Nanofibers for Periodontal Treatment: A Recent Progress

Management of Operational Parameters and Novel Spinneret Configurations for the Electrohydrodynamic Processing of Functional Polymers

Fabrication of Zein‐Based Fibrous Scaffolds for Biomedical Applications—A Review

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