Semiconductor exciton-polaritons in planar microcavities form coherent two-dimensional condensates in non-equilibrium. However, the coupling of multiple lower-dimensional polariton quantum systems, which are critical for polaritonic quantum device applications and novel cavity-lattice physics, has been limited in conventional cavity structures. Here, we demonstrate full non-destructive confinement of polaritons using a hybrid cavity composed of a single-layer subwavelength grating mirror and a distributed Bragg reflector. Single-mode polariton lasing was observed at a chosen polarization. The incorporation of a designable slab mirror in a conventional vertical cavity, when operating in the strong-coupling regime, enables the confinement, control and coupling of polariton gasses in a scalable fashion. This approach may open the door to experimental implementations of polariton-based quantum photonic devices and coupled cavity quantum electrodynamic systems. 2-4 Exciton-polaritons are formed via strong coupling between excitons and photons. Due to the excitonic component, the polaritons are massive, weakly interacting quasiparticles that feature strong nonlinearity and rich many-body physics.5 By mixing with the photon, polaritons have an effective mass that is 10 28 of the hydrogen atomic mass, and they are relatively insensitive to disorder or localization potentials in the active media. Hence, polaritons exhibit quantum coherence over macroscopic scales with high critical temperatures. Polaritons in quantum-well microcavities couple out of the cavity at a fixed rate while conserving the energy and in-plane wavenumber, providing direct experimental access that is unavailable in typical many-body quantum systems. Hallmarks of non-equilibrium condensation and superfluidity have been widely observed in isolated two-dimensional (2D) polariton systems (Ref. 3 and the references therein).Foundational work on 2D polariton systems has inspired theoretical schemes for polariton-based quantum circuits, 6-8 quantum light sources 9-12 and novel quantum phases. 4 Experimental implementation of these schemes requires the control, confinement and coupling of polariton systems, which remain challenging in conventional microcavity structures. Important features of a versatile experimental platform based on polaritons include: first, well-defined zero-dimensional (0D) polaritons as building blocks of a coupled system; second,