Electromagnetic Breast Imaging: Results of a Pilot Study in Women with Abnormal Mammograms

Poplack, Steven P.; Tosteson, Tor D.; Wells, Wendy A.; Pogue, Brian W.; Meaney, Paul M.; Hartov, Alex; Kogel, Christine; Soho, Sandra; Gibson, Jennifer J.; Paulsen, Keith D.

doi:10.1148/radiol.2432060286

Cited by 274 publications

(247 citation statements)

References 34 publications

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“…[24][25][26] We have shown that MT has substantial diagnostic potential, especially in the discrimination of breast cancer from other benign abnormalities. 19 This study reported an AUC [area under the receiver operating characteristic (ROC) curve] as high as 0.89 for breast lesions larger than 1 cm 19 which is comparable to diagnostic outcomes for MR. 5 These results are due to the excellent specificity of the MT technique compared with superior sensitivity as in the case of MR. 27,28 Our MT data indicate that the proportional increase in (electrical) permittivity, which has been observed with increasing breast density, 20,29,30 also results in cancer and reflects higher water content in breast disease. However, the threshold change found in cancer (electrical) conductivity occurs because the amount of water in malignancy is sufficient to saturate its local binding sites leading to an increase in unbound water in cancer that is not evident in either dense normal parenchyma or other benign processes in the breast.…”

Section: Introductionmentioning

confidence: 78%

Integration of microwave tomography with magnetic resonance for improved breast imaging

et al. 2013

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Purpose: Breast magnetic resonance imaging is highly sensitive but not very specific for the detection of breast cancer. Opportunities exist to supplement the image acquisition with a more specific modality provided the technical challenges of meeting space limitations inside the bore, restricted breast access, and electromagnetic compatibility requirements can be overcome. Magnetic resonance (MR) and microwave tomography (MT) are complementary and synergistic because the high resolution of MR is used to encode spatial priors on breast geometry and internal parenchymal features that have distinct electrical properties (i.e., fat vs fibroglandular tissue) for microwave tomography. Methods: The authors have overcome integration challenges associated with combining MT with MR to produce a new coregistered, multimodality breast imaging platform-magnetic resonance microwave tomography, including: substantial illumination tank size reduction specific to the confined MR bore diameter, minimization of metal content and composition, reduction of metal artifacts in the MR images, and suppression of unwanted MT multipath signals. Results: MR SNR exceeding 40 dB can be obtained. Proper filtering of MR signals reduces MT data degradation allowing MT SNR of 20 dB to be obtained, which is sufficient for image reconstruction. When MR spatial priors are incorporated into the recovery of MT property estimates, the errors between the recovered versus actual dielectric properties approach 5%. Conclusions: The phantom and human subject exams presented here are the first demonstration of combining MT with MR to improve the accuracy of the reconstructed MT images.

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Section: Introductionmentioning

confidence: 78%

Integration of microwave tomography with magnetic resonance for improved breast imaging

et al. 2013

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“…The imaging with microwaves allows non-destructive evaluation of biological tissues due to the non-ionizing nature of microwaves, since changes in the dielectric properties of tissue can be related to their physiological condition. One of the most promising applications deployed is detection of breast tumors [1][2][3][4]. This is particularly eligible due to the easy approach of the breast for imaging, as well as the breast anatomy where the fatty tissue (with low loss) has a low attenuation impact on the signal.…”

Section: Introductionmentioning

confidence: 99%

Development of Antenna for Microwave Imaging Systems for Breast Cancer Detection

AlHabsi¹,

ARuzaiqi²,

AlHadharami³

et al. 2016

J Mol Imaging Dynam

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Motivation: Breast cancer is a major health problem globally for women causing an appreciable percentage of the yearly female death. Microwave imaging is a promising method in biomedical applications such as breast cancer detection due to its good penetration property, non-ionizing and non-invasive nature which has the potential to be a complementary modality to standard mammography. In this paper, An UWB Microstrip-fed Vivaldi antenna for microwave imaging systems aimed for an early breast cancer detection is developed.

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“…Recent advances in breast imaging include frequency domain inverse-scattering approaches, such as those by Meany et al, which have demonstrated successful numerical and phantom results [5,8] and very promising preliminary clinical studies [9,10]. Additionally, Synthetic Aperture Radar (SAR) based techniques such as Tissue Sensing Adaptive Radar (TSAR) [4,11] and Microwave Imaging via Space Time Beamforming (MIST) [12,13] are proposed.…”

Section: Introductionmentioning

confidence: 99%

A Breast Imaging Model Using Microwaves and a Time Domain Three Dimensional Reconstruction Method

Zhou¹,

Takenaka²,

Johnson³

et al. 2009

PIER

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Abstract-An iterative reconstruction algorithm for three-dimensional (3-D) microwave tomography by using time-domain microwave data is applied to detect breast tumor. A numeric breast model with randomly distributed glandular tissues (random size and permittivity) with a tumor is designed for the calculation of synthetic microwave data. An "air phantom" consisting of a section of polyvinyl chloride (PVC) pipe filled with styrofoam and a thin glass cylinder is constructed for collecting microwave data in laboratory. The "breast" and "air phantom" are reconstructed. Reconstruction results show that the "tumor" in the

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Electromagnetic Breast Imaging: Results of a Pilot Study in Women with Abnormal Mammograms

Abstract: Results from EM breast examinations provide statistical evidence of a mean increase in image contrast of 150%-200% between abnormal (benign and malignant) and normal breast tissue.

Cited by 274 publications

References 34 publications

Integration of microwave tomography with magnetic resonance for improved breast imaging

Integration of microwave tomography with magnetic resonance for improved breast imaging

Development of Antenna for Microwave Imaging Systems for Breast Cancer Detection

A Breast Imaging Model Using Microwaves and a Time Domain Three Dimensional Reconstruction Method

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