We propose the Casimir effect as a general method to observe Lifshitz transitions in electron systems. The concept is demonstrated with a planar spin-orbit coupled semiconductor in a magnetic field. We calculate the Casimir force between two such semiconductors and between the semiconductor and a metal as a function of the Zeeman splitting in the semiconductor. The Zeeman field causes a Fermi pocket in the semiconductor to form or collapse by tuning the system through a topological Lifshitz transition. We find that the Casimir force experiences a kink at the transition point and noticeably different behaviors on either side of the transition. The simplest experimental realization of the proposed effect would involve a metal-coated sphere suspended from a micro-cantilever above a thin layer of InSb (or another semiconductor with large g-factor). Numerical estimates are provided and indicate that the effect is well within experimental reach. FIG. 1. The geometry typically used in experimental measurements of the Casimir force is a gold coated sphere suspended above a planar plate from a cantilever. We consider a lower plate of indium antimonide with an applied magnetic field.takes the schematic formwhere X = X (1+ X ) is the dressed currentcurrent correlation function for plate X while X is the usual current-current correlator derived in linear response theory -a material dependent quantity related to conductivity. It enters the expression in a crucial way, and thus, features in the frequency-dependent conductivity translate to features in the Casimir force. Being able to tune the Casimir force by modifying a material's electromagnetic response would have important applications for precision gravity experiments [7] and applications to nanotechnology [8].From the other direction, and importantly for the subject of this paper, any change of the Casimir force would be an indication of a change in the material's properties. Special geometries [9] and boundary conditions [10] can change the Casimir force to be repulsive, though with symmetric geometries without time-reversal symmetry breaking, one can not escape an attractive effect [11]. Just as a repulsive effect would be a signature of some time-reversal symmetry breaking (such as in the case of two quantum Hall plates [12] or topological insulators with gapped surface states [13]), other changes in the Casimir force can be attributed to other material properties. For instance, Bimonte and coauthors showed that one can in principle measure the change in Casimir energy between a normal and superconducting state [14]. Additionally, the critical Casimir effect [15] can be used to characterize the phase transition and probe finite-size scaling [16], while the thermal Casimir effect [17] has been used to probe phase transitions [18].