Electromechanical Coupling Factor of Breast Tissue as a Biomarker for Breast Cancer

Park, Kihan; Chen, Wenjin; Chekmareva, Marina; Foran, David J.; Desai, Jaydev P.

doi:10.1109/tbme.2017.2695103

Cited by 29 publications

(9 citation statements)

References 40 publications

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“…Implantation of piezoelectric materials in vivo has shown promising results in bone and cartilage regeneration [115 , 116], repairing nerve injuries [59 , 117], breast cancer detection [118] and wound healing [119], which can be attributed to charge generation as a result of physiological stress and body movement on the piezoelectric material [12].…”

Section: The Clinical Relevance Of Computational Studies Of Bone Piezmentioning

confidence: 99%

A review on computer modeling of bone piezoelectricity and its application to bone adaptation and regeneration

Mohammadkhah

Marinković

Zehn

et al. 2019

Bone

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Bone is a hierarchical, multiphasic and anisotropic structure which in addition posses piezoelectric properties. The generation of piezoelectricity in bone is a complex process which has been shown to play a key role both in bone adaptation and regeneration. In order to understand the complex biological, mechanical and electrical interactions that take place during these processes, several computer models have been developed and used to test hypothesis on potential mechanisms behind experimental observations. This paper aims to review the available literature on computer modeling of bone piezoelectricity and its application to bone adaptation and healing. We first provide a brief overview of the fundamentals of piezoelectricity and bone piezoelectric effects. We then review how these properties have been used in computational models of bone adaptation and electromechanical behaviour of bone. In addition, in the last section, we summarize current limitations and potential directions for future work.

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Section: The Clinical Relevance Of Computational Studies Of Bone Piezmentioning

confidence: 99%

A review on computer modeling of bone piezoelectricity and its application to bone adaptation and regeneration

Mohammadkhah

Marinković

Zehn

et al. 2019

Bone

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“…For example, one can envision a workflow in which initial screening is done in the field by the EpiView-D4, and cases requiring more granular assessment of tumor heterogeneity are referred to local clinics for CytoPAN or traditional cell-block pathology analysis, which provides detailed visualization and quantitation of biomarker expression at the level of individual tumor cells 35 . Other technologies that may complement the EpiView-D4 include “digital breast exam” devices that identify tissue abnormalities based on tactile imaging 57 , 58 , piezoelectric palpation 59 , 60 , or microelectromechanical sensing 61 , 62 , that might identify populations with less obvious lesions who may benefit from further workup with our device.…”

Section: Discussionmentioning

confidence: 99%

Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates

et al. 2021

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Management of breast cancer in limited-resource settings is hindered by a lack of low-cost, logistically sustainable approaches toward molecular and cellular diagnostic pathology services that are needed to guide therapy. To address these limitations, we have developed a multimodal cellphone-based platform—the EpiView-D4—that can evaluate both cellular morphology and molecular expression of clinically relevant biomarkers directly from fine-needle aspiration (FNA) of breast tissue specimens within 1 h. The EpiView-D4 is comprised of two components: (1) an immunodiagnostic chip built upon a “non-fouling” polymer brush-coating (the “D4”) which quantifies expression of protein biomarkers directly from crude cell lysates, and (2) a custom cellphone-based optical microscope (“EpiView”) designed for imaging cytology preparations and D4 assay readout. As a proof-of-concept, we used the EpiView-D4 for assessment of human epidermal growth factor receptor-2 (HER2) expression and validated the performance using cancer cell lines, animal models, and human tissue specimens. We found that FNA cytology specimens (prepared in less than 5 min with rapid staining kits) imaged by the EpiView-D4 were adequate for assessment of lesional cellularity and tumor content. We also found our device could reliably distinguish between HER2 expression levels across multiple different cell lines and animal xenografts. In a pilot study with human tissue (n = 19), we were able to accurately categorize HER2-negative and HER2-positve tumors from FNA specimens. Taken together, the EpiView-D4 offers a promising alternative to invasive—and often unavailable—pathology services and may enable the democratization of effective breast cancer management in limited-resource settings.

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“…With the knowledge that piezoelectric tissue properties are determined by proteins, diseases that affect the amount or distribution of these proteins can be detected by piezoelectric sensors. One group proposed that the electromechanical coupling factor, controlled by collagen, could aid in detecting breast cancer [35]. A similar idea was presented for the…”

Section: Biological Piezoelectric Materialsmentioning

confidence: 95%

“…Muscle Actin and myosin [18] Hair Keratin [16] Bone Collagen [32] Tendon Collagen [33] Lung tissue Elastin [34] Skin (dermis) Collagen [28] Skin (horny layer and epidermis) Keratin [28] Breast tissue Collagen [35] Outer hair cell Prestin [36] detection of atherosclerosis in the aorta, however as mentioned in a prior paragraph the validity of the aorta's piezoelectric nature is still under debate [48]. In this paper, they claimed the PFM amplitude increased as a function of advancing atherosclerosis and could help with early detection of the disease.…”

Section: Organ Piezoelectric Moleculementioning

confidence: 99%

Piezoelectric Materials for Medical Applications

Chen-Glasser¹,

Li²,

Ryu³

et al. 2018

Piezoelectricity - Organic and Inorganic Materials and Applications

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This chapter describes the history and development strategy of piezoelectric materials for medical applications. It covers the piezoelectric properties of materials found inside the human body including blood vessels, skin, and bones as well as how the piezoelectricity innate in those materials aids in disease treatment. It also covers piezoelectric materials and their use in medical implants by explaining how piezoelectric materials can be used as sensors and can emulate natural materials. Finally, the possibility of using piezoelectric materials to design medical equipment and how current models can be improved by further research is explored. This review is intended to provide greater understanding of how important piezoelectricity is to the medical industry by describing the challenges and opportunities regarding its future development.

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Electromechanical Coupling Factor of Breast Tissue as a Biomarker for Breast Cancer

Cited by 29 publications

References 40 publications

A review on computer modeling of bone piezoelectricity and its application to bone adaptation and regeneration

A review on computer modeling of bone piezoelectricity and its application to bone adaptation and regeneration

Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates

Piezoelectric Materials for Medical Applications

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