Electromechanics of polarized cell growth

Lipchinsky, Andrei

doi:10.1016/j.biosystems.2018.10.004

Cited by 6 publications

(3 citation statements)

References 169 publications

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“…2e, h). Anionic efflux at the tip, which contributes to the largest electrical currents in growing lily (Lilium longiflorum) pollen tubes 33 , appears to respond to the electrochemical imbalance generated by AHAs at the shank, which would be expected to contribute to a net hyperpolarization of the plasma membrane 32,34 . Indeed, cationic influx at the tip can be elicited by hyperpolarizing pulses applied to the shank of lily pollen tubes 32 , supporting a link between tip fluxes and shank membrane potential.…”

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confidence: 99%

“…Local ionic fluxes precede pattern formation and polarized growth in a diverse array of tip-growing cells such as algal zygotes, fungal hyphae, and growing neurons (reviewed in ref. 33 ), such that depolarization of the tip may be a pre-condition to sense external stimuli 5 . Indeed, ion gradients have been reported in virtually all biological models for polar growth 63 , while H + has long been proposed as a crucial signal for pollen tube growth in particular 64,65 .…”

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Plasma membrane H+-ATPases sustain pollen tube growth and fertilization

et al. 2020

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Pollen tubes are highly polarized tip-growing cells that depend on cytosolic pH gradients for signaling and growth. Autoinhibited plasma membrane proton (H +) ATPases (AHAs) have been proposed to energize pollen tube growth and underlie cell polarity, however, mechanistic evidence for this is lacking. Here we report that the combined loss of AHA6, AHA8, and AHA9 in Arabidopsis thaliana delays pollen germination and causes pollen tube growth defects, leading to drastically reduced fertility. Pollen tubes of aha mutants had reduced extracellular proton (H +) and anion fluxes, reduced cytosolic pH, reduced tip-toshank proton gradients, and defects in actin organization. Furthermore, mutant pollen tubes had less negative membrane potentials, substantiating a mechanistic role for AHAs in pollen tube growth through plasma membrane hyperpolarization. Our findings define AHAs as energy transducers that sustain the ionic circuit defining the spatial and temporal profiles of cytosolic pH, thereby controlling downstream pH-dependent mechanisms essential for pollen tube elongation, and thus plant fertility.

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Plasma membrane H+-ATPases sustain pollen tube growth and fertilization

et al. 2020

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“…способность к актуации, то есть к (электро)механической активности (пп. IV, V), как на уровне конформационной динамики ультрамикроструктуры и пор, «каналомиметиков» [5,14,20,99,130,140], так и на уровне материала или покрытия как интегрального целого [41, 78,98,167], адекватно параметрам согласования (п. III), работающим в передаточной функции возбудимой среды (п. II), а значит, в её эквивалентной схеме; VII. способность к сенсингу, основанному на реактивности (п. II) и преобразовании сигнала / энергии (согласно п. IV).…”

Section: комплексные критерии активных биосовместимыхunclassified

Biocompatible Biomimetic Polymer Structures With an Active Response for Implantology and Regenerative Medicine Part I: Basic Principles of the Active Implant’s Biocompatibility

Градов

Gradova

Kochervinskiĭ

2023

SJLSA

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Physical and chemical criteria of biocompatibility of the active polymer implants and stimuli-responsive scaffolds are considered. From the standpoint of the surface physics and controlled wetting, the possibilities of dynamic control of biocompatibility and adaptive changes in the implant properties in response to the signal from the surrounding tissues are considered. The basic properties of the active biocompatible and biomimetic implantable materials, which distinguish them from the passive implants, are summarized. The latter include: electrophysical and electrophysiological membrane biocompatibility (up to the analogy with biomembranes – the so-called Fendler’s “membrane mimetics”); excitability, that is, the ability to qualitatively change their state in response to the external stimulus; compatibility of the matching parameters and impedances of biomembranes and active implantable materials; the presence of the main types of the energy conversion characteristic of biomembranes (chemiosmotic, electrochemical, electromechanical, etc.); the ability to transport and release pharmaceuticals consistent with the parameters of the cellular microenvironment and regulated by its state. Due to the qualitative change in the biomedical aim of such implants (from replacing the natural function to its regeneration and maintenance), there is a possibility of implementing various new biologically relevant functions using these materials, such as the ability to sensing and actuation, based on their reactivity and signal / energy conversion capacity. Of particular interest is the adaptive realization of the above functions in a growing and developing organism during its ontogenesis.

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