Electromyographic and laboratory findings in acute Solanum torvum poisoning*

Glover, Robert L.; Connors, Nicholas J.; Stefan, Cristiana; Wong, Ernest; Hoffman, Robert S.; Nelson, Lewis S.; Milstein, Mark J.; Smith, Silas W.; Swerdlow, Michael

doi:10.3109/15563650.2015.1110749

Cited by 7 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S. torvum revealed the presence of flavanoids, alkaloids, sterols and triterpenes which may be responsible for anti-ulcer property (Agrawal et al, 2010). Electrophysiological findings have never been described in affected patients (Glover et al, 2014). Torvoside M and N have antimicrobial activity and cytotoxic effect on PC-12 and HCT-116 cell lines.…”

Section: Solanum Torvum Swmentioning

confidence: 96%

Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries

Fokou

Nyarko

Appiah–Opong

et al. 2015

Journal of Ethnopharmacology

View full text Add to dashboard Cite

This review compiles for the first time ethnopharmacologically useful plants against BU. The phamacological potential of 13 of them has been demonstrated in vitro and support BU evidence-based traditional medicines. In addition, 7 species showed activity in BU patients and have emerged as a promising source of the traditional medicine for treatment of BU. Yet, further safety and efficacy study should be initiated prior any approval as alternative therapy. Overall, a huge gap in knowledge appeared, suggesting further well-planned and detailed investigations of the in vitro, in vivo, and safety properties of the claimed anti-BU plants. Therefore, plants with medicinal potential should be scrutinized for biologically active compounds, using bioassay-guided fractionation approach to provide new insights to find novel therapeutics for BU control.

show abstract

Section: Solanum Torvum Swmentioning

confidence: 96%

Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries

Fokou

Nyarko

Appiah–Opong

et al. 2015

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

“…The physical examination demonstrated a lucid mental status, intact, opsoclonus, miosis, dysmetria, severe dysarthria, mild extremity, weakness, tenderness and inability to ambulate. Moreover, solasonine and solanidine were also found to be present in the serum [37]. In another patient case study, ingestion of Veratrum viride showed vomiting, bradycardia, nausea and hypotension.…”

Section: Poisoning Cases Of Solanidine In Human Beingmentioning

confidence: 98%

An update of therapeutic potential and bioanalytical aspects of steroidal glycoalkaloid (solanidine)

Patel¹,

Kumar²,

Patel³

2017

JCLM

View full text Add to dashboard Cite

“…Both the pontine nucleus raphe interpositus and fastigial nucleus are primarily regulated by glutamate and GABA, and the high doses of PCP may lead to their disinhibition. This could give rise to ocular flutter or opsoclonus [5,49].…”

Section: Phencyclidine (Pcp) [9]mentioning

confidence: 99%

Drug- and Toxin-Induced Opsoclonus – a Systematized Review, including a Case Report on Amantadine-Induced Opsoclonus in Multiple System Atrophy

Cannilla,

Messe,

Girardin

et al. 2024

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

Background: Opsoclonus is a rare disorder characterized by conjugate multidirectional, horizontal, vertical, and torsional saccadic oscillations, without intersaccadic interval, resulting from dysfunction within complex neuronal pathways in the brainstem and cerebellum. While most cases of opsoclonus are associated with autoimmune or paraneoplastic disorders, infectious agents, trauma, or remain idiopathic, opsoclonus can also be caused by medications affecting neurotransmission. This review was prompted by a case of opsoclonus occurring in a patient with Multiple System Atrophy, where amantadine, an NMDA-receptor antagonist, appeared to induce opsoclonus.Methods: Case report of a single patient and systematized review of toxic/drug-induced opsoclonus, selecting articles based on predefined criteria and assessing the quality of included studies. Results:The review included 30 articles encompassing 158 cases of toxic/drug-induced opsoclonus. 74% of cases were attributed to bark scorpion poisoning, followed by 9% of cases associated with chlordecone intoxication. The remaining cases were due to various toxics/drugs, highlighting the involvement of various neurotransmitters, including acetylcholine, glutamate, GABA, dopamine, glycine, and sodium channels, in the development of opsoclonus. Conclusion:Toxic/drug-induced opsoclonus is very rare. The diversity of toxics/drugs impacting different neurotransmitter systems makes it challenging to define a unifying mechanism, given the intricate neuronal pathways underlying eye movement physiology and opsoclonus pathophysiology.

show abstract

Electromyographic and laboratory findings in acute Solanum torvum poisoning*

Cited by 7 publications

References 4 publications

Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries

Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries

An update of therapeutic potential and bioanalytical aspects of steroidal glycoalkaloid (solanidine)

Drug- and Toxin-Induced Opsoclonus – a Systematized Review, including a Case Report on Amantadine-Induced Opsoclonus in Multiple System Atrophy

Contact Info

Product

Resources

About