A study was made of the EMG in 20 normal test subjects (10 men and 10 women), 10 hemiparetic patients with a pyramidal syndrome, and 10 Parkinson patients. Under standardized conditions, a constant tension of 2,000 g was exerted with the adductor pollicis muscle during 60 sec. The EMG of this muscle was derived with surface and needle electrodes, submitted to analogous digital conversion and analysed with the aid of a PDP 8/I computer. Special attention was focused on the study of change in integrated amplitude, peak-to-peak amplitude, and the number of peaks in response to fatigue. It was found that women in the normal group had a lower ‘efficiency of electrical activity’ than normal men. In paretic patients, amplitudes measured with surface electrodes were relatively high and those measured with needle electrodes relatively low (poor synergistic action). The normal increase in amplitude in response to fatigue is absent in measuring with needle electrodes, but is observed with surface electrodes (exhaustion compensated by adjacent muscles of the same group). In Parkinson patients, too, normal increase in amplitude was measured with surface electrodes, whereas decreased amplitudes were found with needle electrodes.