Electron beam crosslinked PEO and PEO/PVA hydrogels for wound dressing

Yoshii, Fumio; Zhanshan, Yang; Isobe, Kotaro; Shinozaki, Kazuteru; Makuuchi, Keizo

doi:10.1016/s0969-806x(98)00318-1

Cited by 179 publications

(99 citation statements)

References 6 publications

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“…The wound dressing and skin repair materials should have excellent ability to absorb exudates, prevent bacterial infection, inhibit bleeding and maintain proper water, electrolyte balance [44]. Nevertheless, due to low strength and elasticity some commercial wound dressings did not satisfy ideal healing requirements as they tend to stick to wound surface or crushed under high stress [45]. The cellulose acetate polymer is a hydrophilic polymer with good liquid transport and water absorption abilities.…”

Section: Polymer Powdermentioning

confidence: 99%

Impact of Biofield Treatment on Chemical and Thermal Properties of Cellulose and Cellulose Acetate

Trivedi¹,

Nayak²,

Patil³

2015

J Bioengineer & Biomedical Sci

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Cellulose being an excellent biopolymer has cemented its place firmly in many industries as a coating material, textile, composites, and biomaterial applications. In the present study, we have investigated the effect of biofield treatment on physicochemical properties of cellulose and cellulose acetate. The cellulose and cellulose acetate were exposed to biofield and further the chemical and thermal properties were investigated. X-ray diffraction study asserted that the biofield treatment did affect the crystalline nature of cellulose. The percentage of crystallite size was found increased significantly in treated cellulose by 159.83%, as compared to control sample. This showed that biofield treatment was changing the crystalline nature of treated cellulose. However treated cellulose acetate showed a reduction in crystallite size (-17.38%) as compared to control sample. Differential Scanning Calorimetry (DSC) of treated cellulose showed no improvement in melting temperature as compared to control sample. Contrarily cellulose acetate showed significant improvement in melting temperature peak at 351.91ºC as compared to control (344ºC) polymer. Moreover percentage change in latent heat of fusion (∆H) was calculated from the DSC thermogram of both treated and control polymers. A significant increase in percentage ∆H of both treated cellulose (59.09%) and cellulose acetate (105.79%) polymers indicated that biofield treatment enhanced the thermal stability of the treated polymers. CHNSO analysis revealed a significant change in percentage hydrogen and oxygen of treated cellulose (%H-17.77, %O-16.89) and cellulose acetate (%H-5.67, %O-13.41). Though minimal change was observed in carbon percentage of both treated cellulose (0.29%) and cellulose acetate (0.39%) polymers as compared to their respective control samples. Thermo gravimetric analysis and Differential thermo gravimetric (TGA-DTG) analysis of treated cellulose acetate (353ºC) showed increased maximum thermal decomposition temperature as compared to control polymer (351ºC). This showed the higher thermal stability of the treated cellulose acetate polymer; although the maximum thermal decomposition temperature of treated cellulose (248ºC) was decreased as compared to control cellulose (321ºC). These outcomes confirmed that biofield treatment has changed the physicochemical properties of the cellulose polymers.

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Section: Polymer Powdermentioning

confidence: 99%

Impact of Biofield Treatment on Chemical and Thermal Properties of Cellulose and Cellulose Acetate

Trivedi¹,

Nayak²,

Patil³

2015

J Bioengineer & Biomedical Sci

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“…The solutions were placed in glass ampoules of 3 mm diameter. The reactant mixtures were deaerated by nitrogen atmosphere to remove air molecules from binary solution and sealed and irradiated to different doses (kGy) at ambient temperature in a 60 Co γ-cell at a fixed dose rate of 3.08 kGy h −1 . Fresh hydrogels obtained in long cylindrical shapes were cut into pieces of 3-4 mm in length.…”

Section: Preparation Of Hydrogel Specimensmentioning

confidence: 99%

“…[60] The hardness of a wound dressing should not be so low, because in this case it may stick to the wound surface and disrupt healing process. The hardness results of prepared hydrogel specimens are exposed in Figure 8(b).…”

Section: Mechanical Properties Of Hydrogelmentioning

confidence: 99%

“…In addition, the hardness results reveal that the incorporation of PLAA chains into the PAAm hydrogel networks gains the wound dressing a convenient higher hardness and therefore lower adhesion to the wound surface, and therefore accelerating the healing process of wound. [60] 3.8. Permeability of water vapor and adhesiveness degree Hydrogels which are used as wound dressing materials would avoid or at least reduce the body liquid loss through controlling absorption and transmission as well as keeping the high humidity in the wound area in order to accelerate the healing process.…”

Section: Mechanical Properties Of Hydrogelmentioning

confidence: 99%

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Synergistic effect of poly(acrylamide)-incorporated poly(L-ascorbic acid) hydrogels in controlled release and wound dressings

Awadallah‐F

2013

Designed Monomers and Polymers

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In this study, hydrogel specimens were synthesized by acrylamide (AAm) implying different quantities of L-ascorbic acid (LAA) vis-à-vis γ-rays radiation technique. The prepared gels were characterized by various techniques. Fix's theory was applied to poly(acrylamide) (P(AAm)/LAA) hydrogels and diffusion coefficients were evaluated. Hardness, water vapor transmission rate, tensile strength, and degree of adhesiveness were preformed on gel systems. The outcome results indicate that the hydrogel specimens are conveniently utilized in wound dressings as the first application. The second application of this gel system is drug release of anti-fungal terbinafine hydrochloride (TER-HCl), which was used in skin wound healings. Adsorption and release of TER-HCl to and fro from P(AAm/LAA) hydrogel specimens were examined. The impact of PLAA quantities into the gelling specimens on the adsorption capacities and the impact of pH on the releasing behavior of TER-HCl were investigated. The results showed the TER-HCl adsorption capacities of hydrogels are found to rise up from 9.5 ± 0.22 to 99 ± 0.18 mg TER-HCl per g dry gel, dependent on the gradient increment in quantity of PLAA in the gel structures. The results of in vitro TER-HCl release in different buffer solutions revealed that the paramount parameters affecting the drug release behavior of gel systems are pH of surrounding media and quantity of PLAA inside. In sum up, the prepared hydrogels have synergistic effect and they may be utilized in wound dressing and TER-HCl drug release of skin wound healings applications as well.

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“…Similarly, biocomposite nanofibers were also prepared using of HAp with chitosan/PVA for biomedical applications . PEO is also a biocompatible polymer (Griffith, 2000) that has been used as a wound dressing (Yoshii et al, 1999) and cartilage tissue repair (Sims et al, 1996;Subramanian et al, 2005). The PEO had previously been electrospun (Doshi & Renekar, 1995;Fong et al, 1999;Deitzel et al, 2001a;Deitzel et al, 2001b) with chitosan.…”

Section: Electrospinning Of Chitosanmentioning

confidence: 99%

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Jayakumar¹,

Nair²,

Furuike³

et al. 2010

Tissue Engineering

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Chitin and its deacetylated derivative, chitosan, are non-toxic, biodegradable biopolymers currently being developed for use in biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and sensors. Recently, nano fibrous scaffolds based on chitin or chitosan have potential applications in tissue engineering. Tissue engineering is one of the most exciting interdisciplinary and multidisciplinary research areas today, and there has been exponential growth in the number of research publications in this area in recent years. It involves the use of living cells, manipulated through their extracellular environment or genetically to develop biological substitutes for implantation into the body and/or to foster remodeling of tissues in some active manners. Electrospun chitin and chitosan nano fibrous scaffolds would be used to produce tissue engineering scaffolds with improved cytocompatibility, which could mimic the native extracellular matrix (ECM). Electrospinning is truly a feasible means of producing nano fibrous scaffolds that resemble the ECM, however, moreover than this, it is imperative that the effects of an artificial matrix has on cell growth, proliferation, and differentiation. This review summarizes the recent progress in chitin and chitosan based nano fibrous scaffolds with an emphasis in tissue engineering applications.

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Electron beam crosslinked PEO and PEO/PVA hydrogels for wound dressing

Cited by 179 publications

References 6 publications

Impact of Biofield Treatment on Chemical and Thermal Properties of Cellulose and Cellulose Acetate

Impact of Biofield Treatment on Chemical and Thermal Properties of Cellulose and Cellulose Acetate

Synergistic effect of poly(acrylamide)-incorporated poly(L-ascorbic acid) hydrogels in controlled release and wound dressings

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

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