Abstract-This paper reports on integration of two Si charge quantum bits (qubits) and series-connected double single-electron transistors (DSETs) as a readout for the first time. We design and fabricate the DSETs composed of double quantum dots (DQDs) connected in series with two side gates patterned on a silicon-on-insulator substrate.The individual SETs are sufficiently sensitive to detect single-charge polarization on the adjacent charge qubits. The fabricated DSETs are characterized at the temperature of 4.2 K by changing the gate voltages applied to two side gates.The measured Coulomb oscillation characteristics exhibit a clearly-defined hexagon pattern, manifesting that the patterned DQDs of the DSETs indeed act as interacting charging islands. These results agree very well with the results of equivalent circuit simulation combined with three-dimensional capacitance simulation. Furthermore, we simulate how single-charge configurations on two charge qubits are sensed with the DSETs by using the measured electrical characteristics for the DSET and the equivalent model. Finally, the scaling-up properties of the proposed system to multiple single-electron transistors (MSETs) is discussed by simulating Triple Single-Electron Transistors (TSETs) with triple qubits.