“…During extracellular synthesis of metallic myconanoparticles, fungal cells release enzymes and-or metabolites outside the cell wall that will be utilized as a reducing agent in the reduction of metallic ion to fabricate myconanoparticles [ 9 ]. This is the most extensively used method, since no further processing is required to extract the nanoparticles from the cells [ 19 , [24] , [25] , [26] ] No doubt, the nanoparticles must be further purified to remove impurities and fungal residues that can be done by using simple methods such as gel filtration, membrane filtration, ultracentrifugation and dialysis [ [27] , [28] , [29] ]. On the other hand, during intracellular synthesis of myconanoparticles, the precursor (metal) is added to fungal mycelium and then internalized in the fungal biomass.…”