Electron capture induced dissociation of nucleotide anions in water nanodroplets

Liu, Boming; Haag, Nicole; Johansson, H.; Schmidt, H. T.; Cederquist, H.; Nielsen, Steen Brøndsted; Zettergren, Henning; Hvelplund, P.; Manil, B.; Huber, B. A.

doi:10.1063/1.2839597

Cited by 30 publications

(33 citation statements)

References 19 publications

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“…On the other hand, the subsequent fragmentation is certainly modified by the presence of solvent. The rapid coupling of vibrational energy into the solvent should occur on a time scale on the order of tens of picoseconds, making fragmentation energetically inaccessible [24]. In the gas phase, there is no such fast relaxation into the solvent, and fragmentation occurs on a multinanosecond [25] to microsecond [26] time scale.…”

Section: Introductionmentioning

confidence: 99%

UV-photodissociation of non-cyclic and cyclic mononucleotides

Marcum

Kaufman

Weber

2011

International Journal of Mass Spectrometry

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Section: Introductionmentioning

confidence: 99%

UV-photodissociation of non-cyclic and cyclic mononucleotides

Marcum

Kaufman

Weber

2011

International Journal of Mass Spectrometry

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“…Because the main component of living tissues is water, a first approach is to consider molecule-water clusters. [8,9] An alternative to experiments with such nanohydrated complexes is to study clusters of biomolecules. [10,11] Since DNA carries the genetic information, most of the studies have been focused on its constituents.…”

Section: Introductionmentioning

confidence: 99%

Ion‐Induced Fragmentation of Amino Acids: Effect of the Environment

et al. 2011

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In general, radiation-induced fragmentation of small amino acids is governed by the cleavage of the C-C(α) bond. We present results obtained with 300 keV Xe(20+) ions that allow molecules (glycine and valine) to be ionised at large distances without appreciable energy transfer. Also in the present case, the C-C(α) bond turns out to be the weakest link and hence its scission is the dominant fragmentation channel. Intact ionised molecules are observed with very low intensities. When the molecules are embedded in a cluster of amino acids, a protective effect of the environment is observed. The fragmentation pattern changes: the C-C(α) bond becomes more protected and stable amino acid cations are observed as fragments of the molecular clusters. Evidently, the molecular cluster acts as a "buffer" for the excess energy, capable of rapidly redistributing excess energy and charge.

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“…This could be explained by the relative importance of the electron-capture process in comparison to the other dissociation channels as a function cluster size, i.e., the former being approximately constant with increasing cluster size [32]. We can mention that, in collision-induced fragmentation of water-solvated anions of adenosine 5 -monophosphate (AMP) with Na atoms, Liu et al [33,34] observed that the electron-capture process leads to a more important damaging effect when increasing the number of initially attached water molecules while they observed a protective behavior of the water molecules for collision-induced dissociation processes without electron transfer.…”

Section: Resultsmentioning

confidence: 99%

Collision-induced dissociation of protonated water clusters

et al. 2014

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Collision-induced dissociation (CID) has been studied for protonated water clusters H + (H 2 O) n , with n = 2-8, colliding with argon atoms at a laboratory energy of 8 keV. The experimental data have been taken with an apparatus (Device for Irradiation of Molecular Clusters, 'Dispositif d'Irradiation d'Agrégats Moléculaire,' DIAM) that has been recently constructed at the Institut de Physique Nucléaire de Lyon. It includes an event-by-event mass spectrometry detection technique, COINTOF (correlated ion and neutral fragment time of flight). The latter device allows, for each collision event, to detect and identify in a correlated manner all produced neutral and charged fragments. For all the studied cluster ions, it has allowed us to identify branching ratios for the loss of i = 1 to i = n water molecules, leading to fragment ions ranging from H + (H 2 O) i=n−1 all the way down to the production of protons. Using a corresponding calibration technique we determine total charged fragment production cross sections for incident protonated water clusters H + (H 2 O) n , with n = 2-7. Observed trends for branching ratios and cross sections, and a comparison with earlier data on measured attenuation cross sections for water clusters colliding with other noble gases (He and Xe), give insight into the underlying dissociation mechanisms.

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Electron capture induced dissociation of nucleotide anions in water nanodroplets

Cited by 30 publications

References 19 publications

UV-photodissociation of non-cyclic and cyclic mononucleotides

UV-photodissociation of non-cyclic and cyclic mononucleotides

Ion‐Induced Fragmentation of Amino Acids: Effect of the Environment

Collision-induced dissociation of protonated water clusters

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