Electron-microscopic studies on Kupffer's stellate cells and sinusoidal endothelial cells in the liver of normal and experimental rabbits

Fine structural and cytochemical aspects of granuloma formation derived from kupffer cells in mice injected with latex particles.

“…WIDMANN and FAHIMI (1975) reported that latex particles larger than 0.8 im in diameter were never taken up by the sinusoidal endothelial cells of the liver, but in our study large particles, 2.0 pm in diameter could be taken up into this type of cell, though not so often, in addition to smaller particles of 0.2 pm in diameter. We wish to emphasize that the hepatic sinusoidal endothelial cell is also involved in cleaning up the blood stream as TAMARU andFUJITA (1978) andFUJITA et al (1983) reported, though this type of cell essentially differs from the Kupffer cell in morphology (WIssE,1972(WIssE, ,1974a(WIssE, ,1977MoTTA,1975;MUTO,1977;MUTO et al, 1977) and in the grade of endocytotic activity (WIDMANN and FAHIMI,1975). It is well known that the Kupffer cell characteristically shows peroxidase activity in the cisternae of its rough endoplasmic reticulum and nuclear envelope (FAHIMI, 1970;WIDMANN et al, 1972;WISSE, 1974a).…”

Ultrastructure of Macrophages of the Murine Peyer’s Patch Dome

“…Since macrophages from both car bon-fed and control mice contained dark ma terial, it was not always possible to distin guish carbon particles from other debris. Endocytized carbon has previously been noted to accumulate in large fluffy masses, often surrounded by a vacuole [15,21,23,29], Similar vacuole-enclosed masses of carbon were seen in Peyer's patch macrophages. Car bon was more often present as irregular clus ters of amorphous dark material which was not enclosed in a vacuole but appeared to lie free in the cytoplasm.…”

The three-dimensional microanatomy of the liver.

“…These aspects suggest that the larger fenestrations might owe their existence to a temporary injury of the sinusoidal barrier and a parallel defense mechanism of activated macrophages (MOTTA, , 1979. The general architecture of the mammalian fetal liver has been reported in a number of TEM studies mostly dealing with hepatic hemopoiesis in various developmental stages (ZAMBONI, 1965;KOGA, 1971;FUKUDA, 1974;TAMARU and FUJITA, 1978). On the other hand, few SEM observations of fetal liver have been reported MOTTA and MAKABE, 1980).…”