Electron Microscopic Study of Liver Mitochondria from Human Alcoholics

Kiessling, K.‐H.; Lindgren, Lennart; Strandberg, B.; Tobé, Ulla

doi:10.1111/j.0954-6820.1964.tb00662.x

Cited by 25 publications

(1 citation statement)

References 8 publications

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“…One of the early and most consistent alterations in the liver of the chronic ethanol consumer is a change in the structure and function of mitochondria, which has been demonstrated in alcoholic patients (Edmondson et al, 1967; Kiessling et al, 1964), as well as in primate (Arai et al, 1984) and rodent (Cunningham et al, 1990; Kiessling and Tobe, 1964) models of alcoholic liver disease. The mitochondria are enlarged, often misshapen, and demonstrate disrupted and aggregated cristae.…”

Section: Discussionmentioning

confidence: 99%

Ethanol Self‐Administration and Alterations in the Livers of the Cynomolgus Monkey, Macaca fascicularis

Ivester

Roberts

Young

et al. 2006

Alcoholism Clin & Exp Res

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Our studies show that cynomolgus monkeys undergoing voluntary ethanol consumption for 1.5 years exhibit many of the features observed in the early stages of human alcoholic liver disease. Ethanol-elicited fatty liver, inflammation, and elevated serum aspartate amino transferase were evident with a diet that contained modest amounts of polyunsaturated lipids. The dramatic increases in urinary IsoP demonstrated that the animals were being subjected to significant oxidative stress that correlated with their level of ethanol consumption.

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Section: Discussionmentioning

confidence: 99%

Ethanol Self‐Administration and Alterations in the Livers of the Cynomolgus Monkey, Macaca fascicularis

Ivester

Roberts

Young

et al. 2006

Alcoholism Clin & Exp Res

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Ultrastructural identification of light microscopic giant mitochondria in alcoholic liver disease

et al. 1992

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Ultrastructural identification of light microscopic giant mitochondria was performed on the same specimens for light and electron microscopic observations. The liver tissue specimens were fixed in OsO4, embedded in epoxy resin, cut 4 microns thick and stained with polychrome. At the beginning of the study a light microscopic observation was made, and a microphotograph was taken. The identification of light microscopic giant mitochondria by conventional microscopy was identified by the occupation rate in liver cells, the negative findings of stainability and the morphological consistency (round, cigar-shaped and granular). The specimens were subsequently embedded again in epoxy resin and cut into ultrathin sections of 400 A. A transillumination electron microscope was used for the observation, and ultrastructural images of light microscopic giant mitochondria revealed that they were crystalloid bodies with a crystalline latticelike structure. The occupation rates within liver cells and the morphological shapes of the crystalloid bodies corresponded with those of light microscopic giant mitochondria. The light microscopic giant mitochondria obviously had different features from those of electron microscopic giant mitochondria and Mallory bodies (Yokoo's type II), although Mallory bodies showed the same staining properties as light microscopic giant mitochondria.

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Myocardial Effects of Alcohol Abuse Clinical and Physiologic Consequences

Thiel

Gavaler

1985

Recent Developments in Alcoholism

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Electron Microscopic Study of Liver Mitochondria from Human Alcoholics

Cited by 25 publications

References 8 publications

Ethanol Self‐Administration and Alterations in the Livers of the Cynomolgus Monkey, Macaca fascicularis

Ethanol Self‐Administration and Alterations in the Livers of the Cynomolgus Monkey, Macaca fascicularis

Ultrastructural identification of light microscopic giant mitochondria in alcoholic liver disease

Myocardial Effects of Alcohol Abuse Clinical and Physiologic Consequences

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