Electron microscopy of the human nasal mixed glands

Toppozada, Hussein H.; Gaafar, Hazim A.

doi:10.1017/s0022215100077422

Cited by 23 publications

(13 citation statements)

References 7 publications

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“…This will not require any diminution through absorption by the microvilli lining the lumina of the serous glands, which therefore will temporarily loose their function and undergo atrophy or disappear. This supports the absorptive function of these microvilli as mentioned by Toppozada and Gaafar (1973). There is also continuous nasal respiratory obstruction which will result in diminished access to the nose of traumatizing particles of dust, fumes and microorganisms, which will not require the protec tive action of the nasal mucous blanket and will be washed away by the copious serous secretion.…”

Section: Discussionsupporting

confidence: 71%

“…(1) Absence of the mucous-secreting cells, which may be due to: (a) a balancing mechanism of secretion that occurred between the tunical mucous glands and the goblet cells, both of which secrete the same mucigen (Toppozada and Gaafar, 1973). As the goblet cells increased in number and activity in allergic cases, increasing the mucous element of the nasal secretion, the mucous glands either atrophied or were transformed into serous units, or (b) hyper activity of the cholinergic nervous system which occurs in allergic cases causes vascular dilatation and increased vascular permeability with increased tissue fluid formation.…”

Section: Discussionmentioning

confidence: 99%

“…The ultrastructure of the normal human nasal seromucinous glands was described by Toppozada and Gaafar (1973). Jahnke (1971Jahnke ( , 1972 described the ultrastructure of the allergic human nasal mucosa.…”

Section: Introductionmentioning

confidence: 99%

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Tunica Propria in Chronic Allergic Rhinitis. Electron-Microscopic Study

Toppozada¹,

Talaat²

1976

ORL

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The fine structure of human nasal sero-mucinous glands was studied in 15 chronic allergic patient. There was total absence of the mucous glands, and proliferation of serous elements, with hugely dilated lumina containing large numbers of intact zymogen granules, and absence of microvilli. The relation between the goblet cells and the nasal glands was discussed. An interchange between the serous and mucous elements was deduced.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

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Tunica Propria in Chronic Allergic Rhinitis. Electron-Microscopic Study

Toppozada¹,

Talaat²

1976

ORL

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“…The serous glands showed their normal characteristic fine structure described by Toppozada and Gaafar (1973).…”

Section: The Lamina Propriamentioning

confidence: 94%

The Allergic Nasal Mucosa following Vidian Neurectomy

Toppozada¹,

Talaat²

1976

ORL

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The fine structure of the allergic nasal mucosa following vidian neurectomy was studied in 15 patients. The structure of the mucous glands, venules, arterioles and tunical cellular elements returned to normal 1 month after the operation, while that of the epithelium and of the capillaries only 3 months post-operatively. The effect of interrupting the hyperactive cholinergic nerve impulses on the various constituents of the nasal mucosa is described.

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“…Peroxidase activity in the human nasal gland was recognized in the nuclear envelope, cisternae of rough-surfaced endoplasmic reticulum, Golgi complex, and secretory granules. A normal human nasal gland consists of seromucous secretion cells and the mucous secretion cells (24). Here, peroxidase activity was recognized only in the seromucous secretion cells.…”

Section: Endogenousmentioning

confidence: 94%

Localization of Peroxidase Activity in the Human Nasal Gland. Comparison of Patients With a House Dust Nasal Allergy to Persons With Normal Glands

Watanabe

1978

Acta Histochem. Cytochem

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Endogenousperoxidase activity was localized in seromucous-secretion cells of human nasal glands with the diaminobenzidine method for light and electron microscopic histochemistry.Localization of the activity occurred in the cisternae of rough surfaced endoplasmic reticulum, including the nuclear envelope, some vesicles and saccules of the Golgi complex, and secreting granules.In the case of patients with a house dust nasal allergy, peroxidase activity in the nasal glands diminished or disappeared.However, activity recovered after reception of steroid hormone (dexamethasone 5 mg/day for 7 days). If nasal glands rely on the same nervous system as do salivary glands, then the diminishing of peroxidase activity may be due to the diminishing of sympathetic stimulation. Therefore, the relationship between nasal allergy and the sympathetic nerve will be considered.The existence of endogenous peroxidase has been confirmed in many types of glands and leucocytes (2,4,6,8,9,12,16,17,21,22,23,25,26). However, these reports were based on experiments with animals, not humans. The present experiment exhibits endogenous peroxidase activity in the human nasal gland. Peroxidase activity in the human nasal gland was recognized in the nuclear envelope, cisternae of rough-surfaced endoplasmic reticulum, Golgi complex, and secretory granules. A normal human nasal gland consists of seromucous secretion cells and the mucous secretion cells (24). Here, peroxidase activity was recognized only in the seromucous secretion cells. In the seromucous secretion cells of patients with a house dust nasal allergy, however, peroxidase activity was extremely reduced or reaction products not present. When corticosteroid hormone was given to the allergic patients, peroxidase activity recovered. The correlation between the nasal allergy to house dust and the existence of peroxidase in the nasal gland will be discussed. MATERIALS AND METHODInferior tubinate mucosa of four normal volunteers, and of eleven patients with a nasal allergy who were positive for both the skin and nasal provocation test for

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Electron microscopy of the human nasal mixed glands

Cited by 23 publications

References 7 publications

Tunica Propria in Chronic Allergic Rhinitis. Electron-Microscopic Study

Tunica Propria in Chronic Allergic Rhinitis. Electron-Microscopic Study

The Allergic Nasal Mucosa following Vidian Neurectomy

Localization of Peroxidase Activity in the Human Nasal Gland. Comparison of Patients With a House Dust Nasal Allergy to Persons With Normal Glands

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