The Allergic Nasal Mucosa following Vidian Neurectomy

Toppozada, Hussein H.; Talaat, M.

doi:10.1159/000275272

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…The ultrastructure of nasal mucosa in patients with AR revealed that the nasal mucosal epithelium had increased ciliary loss with swelling of reaming cilia, few microvilli, widening of intercellular spaces, and eosinophilic infiltration. Also, the sub-epithelial zone had irregular arrangement of collagen fibers with many types of inflammatory cells [45]. Moreover, Knipping and his colleagues [44] showed that the ultrastructure of nasal mucosa from patients with AR revealed that the capillaries were dilated with active and elevated endothelium with many pinocytotic vesicles.…”

Section: Discussionmentioning

confidence: 99%

Adipose Tissue-Derived Mesenchymal Stem Cell Modulates the Immune Response of Allergic Rhinitis in a Rat Model

Ebrahim

Mandour

Farid

et al. 2019

IJMS

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This study was designed to investigate the potential effects and underlying mechanism of adipose tissue-derived mesenchymal stem cells (MSCs) on allergic inflammation compared to Montelukast as an antileukotriene drug in a rat model of allergic rhinitis (AR). The effect of MSCs was evaluated in albino rats that were randomly divided into four (control, AR, AR + Montelukast, and AR + MSCs) groups. Rats of AR group were sensitized by ovalbumin (OVA) and then challenged with daily nasal drops of OVA diluted in sterile physiological saline (50 μL/nostril, 100 mg/mL, 10% OVA) from day 15 to day 21 of treatment with/without Montelukast (1 h before each challenge) or MSCs I/P injection (1 × 106 MCSs; weekly for three constitutive weeks). Both Montelukast and MSCs treatment started from day 15 of the experiment. At the end of the 5th week, blood samples were collected from all rats for immunological assays, histological, and molecular biology examinations. Both oral Montelukast and intraperitoneal injection of MSCs significantly reduced allergic symptoms and OVA-specific immunoglobulin E (IgE), IgG1, IgG2a and histamine as well as increasing prostaglandin E2 (PGE2). Further analysis revealed that induction of nasal innate cytokines, such as interleukin (IL)-4 and TNF-α; and chemokines, such as CCL11 and vascular cell adhesion molecule-1 (VCAM-1), were suppressed; and transforming growth factor-β (TGF-β) was up-regulated in Montelukast and MSCs-treated groups with superior effect to MSCs, which explained their underlying mechanism. In addition, the adipose tissue-derived MSCs-treated group had more restoring effects on nasal mucosa structure demonstrated by electron microscopical examination.

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Section: Discussionmentioning

confidence: 99%

Adipose Tissue-Derived Mesenchymal Stem Cell Modulates the Immune Response of Allergic Rhinitis in a Rat Model

Ebrahim

Mandour

Farid

et al. 2019

IJMS

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“…This is consistent with the morphological data showing an increase in the density and secretory activity of mast cells. Vidian nerve resection induces not only a reduction in the secretory activity of the glands and vasoconstriction of the venous plexus [13,14] but also a significant decrease in histamine tissue levels and histidinedecarboxylase activity. This is associated with reductions in density and in the degranulation index of mast cells, which are frequently observed in heterophagous vacuoles of macrophages.…”

Section: Discussionmentioning

confidence: 99%

“…Rucci et al [13] have demonstrated that stimulation of the vidian nerve in humans is able to induce significant structural and ultrastructural changes in the glandular, vascular and stromal components and in mast cells of the respiratory tract of nasal mucosa [12]. Moreover, there are experimental and clinical studies [14,15] claiming that vidian nerve resection relieves intractable "vasomotor rhinitis". The aim of the present study was to confirm the possibility of a link between the cholinergic nervous system and mast cell histamine by studying the effect of vidian nerve resection on histamine content, histidine-decarboxylase activity, density, degranulation index and morphological features of nasal mucosal mast cells.…”

Section: Introductionmentioning

confidence: 99%

Vidian nerve resection, histamine turnover and mucosal mast cell function in patients with chronic hypertrophic non-allergic rhinitis

et al. 1989

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Parasympathetic innervation of the respiratory tract of nasal mucosa plays an important role in the pathogenesis of chronic hypertrophic non-allergic rhinitis (C.H.N.A.R.), the vidian nerve providing the main parasympathetic nerve supply to respiratory mucosa. The present study investigates the effect of vidian nerve resection in 22 patient with intractable C.H.N.A.R. on histamine content and formation and on the number of mast cells and their degranulation in the respiratory tract. Samples were taken from respiratory mucosa for histamine and histidine-decarboxylase assay, and for microscopic observations for mast cell density and degranulation index, before and 12-24 months after vidian nerve resection. Neurectomy of the vidian nerve completely cured the clinical symptomatology, evaluated by rhinoreomanometry, and also significantly decreased both the high histamine levels and histidine-decarboxylase activity in patients with C.H.N.A.R. The density and degranulation index of mast cells were also significantly lower after surgery. These data suggest a relationship between cholinergic activity and the secretory response of mast cells and indicates a correlation between the parasympathetic nerve supply and chronic hyperthrophic non-allergic rhinitis. The significant reduction in mast cell density, histamine levels and histidine-decarboxylase activity also lends support to the hypothesis that the parasympathetic nerve supply plays a role in the regulation of mast cell histamine.

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“…Toppozada и соавт. [16] различают специфическую (с выявленным «виновным» аллергеном) и неспецифиче-скую (с неустановленным аллергеном) формы вазомотор-ного ринита. Некоторые специалисты считают аллергиче-ский ринит (АР) самостоятельным заболеванием, а не ва-риантом вазомоторного ринита [17,18].…”

Section: вестник оториноларингологии 5 2016unclassified

About the unresolved problems of terminology and classification of allergic rhinitis and the desirability of distinguishing the mixed form of the disease

Gadzhimirzaev

2016

Vestn. otorinolaringol.

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The Allergic Nasal Mucosa following Vidian Neurectomy

Cited by 14 publications

References 6 publications

Adipose Tissue-Derived Mesenchymal Stem Cell Modulates the Immune Response of Allergic Rhinitis in a Rat Model

Adipose Tissue-Derived Mesenchymal Stem Cell Modulates the Immune Response of Allergic Rhinitis in a Rat Model

Vidian nerve resection, histamine turnover and mucosal mast cell function in patients with chronic hypertrophic non-allergic rhinitis

About the unresolved problems of terminology and classification of allergic rhinitis and the desirability of distinguishing the mixed form of the disease

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