Electron spin resonance studies of some irradiated pharmaceuticals

Gibella, M.; Crucq, A.; Tilquin, Bernard; Stocker, Pierre; Lesgards, G.; Raffi, J.

doi:10.1016/s0969-806x(99)00353-9

Cited by 71 publications

(44 citation statements)

References 12 publications

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“…Moreover, the hyperfine structure of the EPR spectrum (when it is well resolved) provides more important information about the radical than the g-value, because most radicals detected are carbon or nitrogen centered radicals and the spectra positions are almost in the same magnetic field range [1]. The EPR technique has been widely used for long time in the identification of irradiation damage centers in many substances including drugs, amino acid and iminodiacetic acid derivatives [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. L-glutamine and iminodiacetic acid powders were gamma-irradiated and studied by EPR at room temperature [19,20].…”

Section: Introductionmentioning

confidence: 99%

EPR study of gamma induced radicals in amino and iminodiacetic acid derivatives

Aydin¹,

Başkan²,

Osmanoglu³

2009

Braz. J. Phys.

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In this study, electron paramagnetic resonance spectroscopy was used to investigate free radicals formed in gamma irradiated L-glutamine hydrochloride, iminodiacetic acid hydrochloride and N-(2-hyroxyethyl) iminodiacetic acid powders. The free radicals produced in L-glutamine hydrochloride powders were attributed to the CH 2Ċ HCOOH radical; and those in iminodiacetic acid hydrochloride and N-(2-hyroxyethyl) iminodiacetic acid powders to the HNCHCH 2 (COOH) 2 and HOCH 2 CH 2 NĊHCH 2 (COOH) 2 , respectively. The g-values of the radicals and the hyperfine structure constants of the free electron with the environmental protons and 14 N nucleus were determined. The samples were not displayed before they were not irradiated. The free radicals were found stable at room temperature for more than six months. Some spectroscopic properties and suggestions concerning possible structure of the radicals are discussed in this paper.

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Section: Introductionmentioning

confidence: 99%

EPR study of gamma induced radicals in amino and iminodiacetic acid derivatives

Aydin¹,

Başkan²,

Osmanoglu³

2009

Braz. J. Phys.

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“…Electron spin resonance (ESR) spectroscopy appears to be well suited for determination of free radical concentrations in complex media and so, it can be used to detect and distinguish between irradiated drugs from unirradiated ones (Gibella et al, 1993;Signoretti et al, 1994;Miyazaki et al, 1994;Onori et al, 1996). As a cephalosporin antibiotic, duricef is used in the treatment of nose, throat, urinary tract and skin infection that are caused by specific bacteria, including staph strep and E. coli, effects of gamma radiation on cephalosporins with various substitutive groups have been reported in different papers (Miyazaki et al, 1994;Onori et al, 1996;Jacobs, 1983;Yũrũs and Korkmaz, 2005;Gibella et al, 2000), but low-and high-temperature kinetic features, structure and activation energies of the radical species involved in the formation of their ESR spectra were investigated in none of these papers, except of few published work (Yũrũs, S and Korkmaz, M., 2005). Eleven of the studied cephalosporins with various substitutive groups have been shown to exhibit, interestingly ESR spectra of unresolved doublet appearence (Onori et al, 1996;Yũrũs and Korkmaz, 2005).…”

Section: Drugs and Medical Products Irradiationmentioning

confidence: 99%

Ionizing Radiation Induced Radicals

Maghraby¹

2012

Current Topics in Ionizing Radiation Research

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“…This type of radiolytic product can be formed by a disproportion radical-radical reaction. Radical mechanisms as studied by esr measurements, were to be considered in the radiolysis of molecular solids as studied by Gibella et al (1999) [6].…”

Section: Colour Modificationmentioning

confidence: 99%

Radiosensitivity study of cefazolin sodium

Crucq

Slegers

Deridder

et al. 2000

Talanta

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The extent of physico-chemical changes induced by irradiation of cefazolin sodium was investigated. The methods used were potency determination, impurity profile, colour measurements and pH measurements. The potency of irradiated samples at 25 kGy was 4 9 2% lower than that of the non irradiated ones. The total amount of related substances increased from 0.72 90.01% in the non irradiated samples to 4.9 9 0.7% in the samples irradiated at 25 kGy. Most of the peaks showed trace amounts ( B 0.01%), the largest one represented 1.2 9 0.5% of the total related substances. Only two peaks were identified by chromatography: the methyl-1,2,3-thiazol-2 thiol-5 and the 7-aminocephalosporanic acid. The latter related substance is only produced by the irradiation of cefazolin sodium. The pH values of the samples were within the specifications of the European Pharmacopoeia. The colour of the cefazolin sodium powder changed from white to yellow upon irradiation. The yellow colour persisted after the dissolution of the powder. Most of the tests carried out met the Pharmacopoeia's specifications, except the one concerning the colour of the solution.

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Electron spin resonance studies of some irradiated pharmaceuticals

Cited by 71 publications

References 12 publications

EPR study of gamma induced radicals in amino and iminodiacetic acid derivatives

EPR study of gamma induced radicals in amino and iminodiacetic acid derivatives

Ionizing Radiation Induced Radicals

Radiosensitivity study of cefazolin sodium

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