Electronic Data Base in Gastroenterological Endoscopy

Claßen, Martin; Wagner, Frederick B.; Swobodnik, W

doi:10.1055/s-2007-1010602

Cited by 11 publications

(5 citation statements)

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“…Moreover the likelihood of efficacy and safety of delivery across the GI barrier with needles is supported by the extensive gastroenterological experience with GI mucosal injection as well as by the literature on the ingestion of foreign objects. Epinephrine injections in the GI tract are part of the standard of care with respect to the treatment of bleeding ulcers as well as polypectomy-induced GI bleeding 9 . Despite being used for localized vasoconstriction of bleeding vessels at ulcer sites, a common observation during these procedures is a near immediate tachycardic response in the patient 9 , supporting the systemic bioavailability of epinephrine when administered via the GI mucosa 10 .…”

Section: Introductionmentioning

confidence: 99%

“…Epinephrine injections in the GI tract are part of the standard of care with respect to the treatment of bleeding ulcers as well as polypectomy-induced GI bleeding 9 . Despite being used for localized vasoconstriction of bleeding vessels at ulcer sites, a common observation during these procedures is a near immediate tachycardic response in the patient 9 , supporting the systemic bioavailability of epinephrine when administered via the GI mucosa 10 . With regards to safety, inadvertent or purposeful ingestion of sharp and foreign objects has helped establish clinical guidelines with respect to object characteristics and object length for risk stratification of clinical complications and therefore guidance for clinical management 11 .…”

Section: Introductionmentioning

confidence: 99%

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Microneedles for Drug Delivery via the Gastrointestinal Tract

Traverso

Schoellhammer

Schroeder

et al. 2015

Journal of Pharmaceutical Sciences

153

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Both patients and physicians prefer the oral route of drug delivery. The gastrointestinal (GI) tract, though, limits the bioavailability of certain therapeutics because of its protease and bacteria-rich environment as well as general pH variability from pH 1–7. These extreme environments make oral delivery particularly challenging for the biologic class of therapeutics. Here we demonstrate proof-of-concept experiments in swine that microneedle-based delivery has the capacity for improved bioavailability of a biologically-active macromolecule. Moreover, we show that microneedle-containing devices can be passed and excreted from the GI tract safely. These findings strongly support the success of implementation of microneedle technology for use in the GI tract.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microneedles for Drug Delivery via the Gastrointestinal Tract

Traverso

Schoellhammer

Schroeder

et al. 2015

Journal of Pharmaceutical Sciences

153

View full text Add to dashboard Cite

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“…The record form provided the examiners with a structured sequence for assessing findings. This means, firstly, that the possibility of overlooking findings is greatly reduced [ 44 , 45 ] and secondly, that a standardisation of the results is achieved. Structured and standardised diagnosis and documentation of X‑ray diagnosis is meanwhile applied in all medical specialities [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of incidental findings in adult vs. adolescent patients in the course of orthodontic X-ray diagnostics

et al. 2022

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Objective Due to increasing numbers of adult patients presenting to orthodontic practices, an increase in incidental findings on diagnostic X‑rays, which are the cornerstone of orthodontic diagnostics, is expected. This raises the clinically relevant question of whether an age effect exists regarding prevalence, localisation and severity of incidental findings on orthodontic diagnostic X‑rays. Materials and methods The clinical, primarily retrospective study examined pathological incidental findings from 600 orthopantomograms (OPT) and lateral cephalogram (LC) images in two groups of orthodontic patients (group I: 150 children/adolescents, age 11.89 ± 2.47 years; group II: 150 adults, age 27.03 ± 10.42 years). Prevalence, localisation and severity of the findings were recorded based on a classification sheet. The assessment was done by three experienced examiners following a systematic approach along the nine locations: mandible, maxilla, dentition, paranasal sinuses, temporomandibular joint, cranial base, orbit, cervical spine, soft tissues. Results In all, 1458 incidental findings were detected, with 66% of the findings having occurred away from the dentition. There was a significant age effect (p < 0.001) with respect to the prevalence of incidental findings (group II—adults 1026 findings—OPT: 566/LC 460 vs. group I—children/adolescents 432 findings—OPT: 221/LC 211). Regarding localisation, incidental findings in adults commonly occurred in the dentition, paranasal sinuses and mandibular regions. Furthermore, analysis of the LC images revealed significantly more incidental findings in the area of the cranial base and cervical spine in adults (p < 0.001, p = 0.003). Categorisation according to the severity of the incidental findings showed that 33% of the incidental findings needed further diagnostic investigation and possibly treatment by other specialities. Conclusion Diagnostic assessment using orthodontic diagnostic X‑rays results in a high prevalence of incidental findings away from the dentition. Particularly in adults, a large number of incidental findings outside the dental/alveolar region may be expected on orthodontic diagnostic X‑rays. Thus, a structured approach during diagnostic assessment is required to minimise the extent to which incidental findings of clinical relevance are overlooked.

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“…El control debe incluir la realización de un estudio por ultrasonografía endoscópica, a los fines de detectar precozmente la presencia de una neoplasia invasiva coexistente. Cualquier lesión visible debe ser removida por resección endoscópica de la mucosa 10,11 .…”

Section: Introduccionunclassified

Concordance of endoscopic and histological findings in patients with Barrett's esophagus

KasprzykSotomayor

Coronel

Díaz-Reissner

et al. 2016

Rev. Nac. (Itauguá)

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RESUMENIntroducción: se denomina esófago de Barrett (EB) a la sustitución del epitelio esofágico escamoso normal de la zona distal, por un epitelio columnar, confirmado mediante la evaluación histológica con la presencia de células caliciformes que indican la presencia de una metaplasia intestinal especializada, constituyendo un desencadenante del desarrollo de adenocarcinoma esofágico. Existe discrepancia entre la interpretación de los hallazgos endoscópicos e histológicos, debido a que se presentan resultados dispares en operadores dependientes. Si bien el riesgo de progresión a malignidad es bajo, se debe establecer criterios adecuados de vigilancia para un manejo eficiente costo-efectivo. Objetivo: determinar la concordancia existente entre los hallazgos endoscópicos e histológicos en pacientes con EB que acudieron al Servicio de Endoscopía Digestiva del Hospital Central del Instituto de Previsión Social (Asunción, Paraguay) del 2012 al 2014. Materiales y Métodos: estudio observacional descriptivo, retrospectivo, de corte transversal. Se revisaron expedientes clínicos de pacientes. Resultados: se tenía sospecha de EB en 1,54% (265/17.207) de los pacientes, en quienes fueron tomadas muestras de biopsias durante la realización de endoscopía digestiva alta. Hubo confirmación histológica en 32,08% (85/265) de los casos, siendo hallada displasia en 16,47% (14/85), correspondiendo la totalidad a displasia de bajo grado. Por tanto, del total de pacientes la frecuencia de EB fue 0,49% (85/17.207). Conclusión: existe una escasa concordancia entre los hallazgos endoscópicos e histológicos de EB. Es una entidad de baja frecuencia en nuestro medio. No fue encontrado ningún caso que conlleve riesgo significativo de malignidad.Palabras claves: esófago de Barrett, endoscopía del sistema digestivo, Paraguay ABSTRACT Introduction: Barrett's esophagus(BE) is called to the replacement of normal epithelial squamous esophagic epithelium by columnar epithelium in the distalend, confirmed by histological evaluation with the presence of goblet cells indicating the presence of specialized intestinal metaplasia, constituting a trigger for the development of esophageal adenocarcinoma.

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Electronic Data Base in Gastroenterological Endoscopy

Cited by 11 publications

References 0 publications

Microneedles for Drug Delivery via the Gastrointestinal Tract

Microneedles for Drug Delivery via the Gastrointestinal Tract

Prevalence of incidental findings in adult vs. adolescent patients in the course of orthodontic X-ray diagnostics

Concordance of endoscopic and histological findings in patients with Barrett's esophagus

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