Electronic device generated light increases reactive oxygen species in human fibroblasts

Austin, Evan; Huang, Amy Y.; Adar, Tony; Wang, Erica; Jagdeo, Jared

doi:10.1002/lsm.22794

Cited by 28 publications

(21 citation statements)

References 26 publications

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“…Light radiation exposure initiates photo oxidative reaction, which impairs with the increase of ROS (Austin, Huang, Adar, Wang, & Jagdeo, 2018).…”

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confidence: 99%

“…Studies suggest that, over time, exposure to the blue end of the light spectrum could cause serious long-term damage to eyes and health problems (eyestrain, headaches, physical and mental fatigue, sleep disorders, etc. )(Austin et al, 2018;Beatty, Koh, Phil, Henson, & Boulton, 2000;Marshall, Gordon, McCauley, de Souza Filho, & Burnier, 2006;Moon et al, 2008). It is well documented that some blue light exposure is essential for good health.…”

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confidence: 99%

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Hydroxytyrosol from olive fruits prevents blue‐light‐induced damage in human keratinocytes and fibroblasts

Avola

Graziano

Pannuzzo

et al. 2018

Journal Cellular Physiology

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Skin aging is a complex biological process influenced by a combination of endogenous or intrinsic and exogenous or extrinsic factors due to environmental damage. The primary environmental factor that causes human skin aging is the ultraviolet irradiation from the sun. Recently, it was established that the long‐term exposure to light‐emitting‐diode‐generated blue light (LED‐BL) from electronic devices seems to have a relevant implication in the molecular mechanisms of premature photoaging. BL irradiation induces changes in the synthesis of various skin structures through DNA damage and overproduction of reactive oxygen species (ROS), matrix metalloproteinase‐1 and ‐12, which are responsible for the loss of the main components of the extracellular matrix of skin like collagen type I and elastin. In the current study, using human keratinocytes and fibroblasts exposed to specific LED‐BL radiation doses (45 and 15 J/cm 2), we produced an in vitro model of skin photoaging. We verified that, compared with untreated controls, the treatment with LED‐BL irradiation results in the alteration of metalloprotease‐1 (collagenase), metalloprotease‐12 (elastase), 8‐dihydroxy‐2′‐deoxyguanosine, proliferating cell nuclear antigen, and collagen type I. Moreover, we showed that the photoaging prevention is possible via the use of hydroxytyrosol extracted from olive fruits, well known for antioxidant properties. Our results demonstrated that hydroxytyrosol protects keratinocytes and fibroblasts from LED‐BL‐induced damage. Thus, hydroxytyrosol might be proposed as an encouraging candidate for the prevention of BL‐induced premature photoaging.

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“…Light radiation exposure initiates photo oxidative reaction, which impairs with the increase of ROS (Austin, Huang, Adar, Wang, & Jagdeo, 2018).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Hydroxytyrosol from olive fruits prevents blue‐light‐induced damage in human keratinocytes and fibroblasts

Avola

Graziano

Pannuzzo

et al. 2018

Journal Cellular Physiology

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“…Short exposures of electronic device generated light (EDGL) increase reactive oxygen species (ROS) generation, but the long-term effects associated with repeated exposures of EDGL are still unknown. 28 …”

Section: Environmental Factors Beyond Uv Radiationmentioning

confidence: 99%

Beyond photoaging: additional factors involved in the process of skin aging

Addor¹

2018

CCID

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Studies assessing the impact of extrinsic factors on skin aging have increased during the last with the increase in life expectancy. Although most of the studies are about the sun radiation impact, many factors should be considered in elderly people, beyond environmental conditions. Lifestyle factors, like diet, sleeping, smoking, should be analyzed carefully, as common age-related conditions (menopause, diabetes, pulmonary diseases, etc.). All these factors could accelerate the natural decline of skin structure and functions, possibly affecting the responses to treatments and drugs. This review demonstrates that growing evidence regarding environmental factors that are associated with lifestyle and comorbidities deserve greater attention from researchers and dermatologists and may require new approaches in the management of skin aging.

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“…ATPs and cAMPs participate in G‐protein‐coupled receptor signaling pathways and activate the downstream cAMP‐dependent protein kinase A, leading to upregulation of responsive genes . Furthermore, the intracellular redox state has been shown to shift after PBM and electronic device generated light .…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis Reveals Anti‐Fibrotic Effects of Blue Light Photobiomodulation on Fibroblasts

et al. 2019

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Background and Objectives This study was aimed at determining the effects of blue light photobiomodulation on primary adult mouse dermal fibroblasts (AMDFs) and the associated signaling pathways. Study Design/Materials and Methods Cultured AMDFs from adult C57BL/6 mice were irradiated by blue light from a light‐emitting diode (wavelength = 463 ± 50 nm; irradiance = 5 mW/cm2; energy density = 4–8 J/cm2). The cells were analyzed using mass spectrometry for proteomics/phosphoproteomics, AlamarBlue assay for mitochondrial activity, time‐lapse video for cell migration, quantitative polymerase chain reaction for gene expression, and immunofluorescence for protein expression. Results Proteomic/phosphoproteomic analysis showed inhibition of extracellular signal‐regulated kinases/mammalian target of rapamycin and casein kinase 2 pathways, cell motility‐related networks, and multiple metabolic processes, including carbon metabolism, biosynthesis of amino acid, glycolysis/gluconeogenesis, and the pentose phosphate pathway. Functional analysis demonstrated inhibition of mitochondrial activities, cell migration, and mitosis. Expression of growth promoting insulin‐like growth factor 1 and fibrosis‐related genes, including transforming growth factor β1 (TGFβ1) and collagen type 1 ɑ2 chain diminished. Protein expression of α‐smooth muscle actin, an important regulator of myofibroblast functions, was also suppressed. Conclusions Low‐level blue light exerted suppressive effects on AMDFs, including suppression of mitochondrial activity, metabolism, cell motility, proliferation, TGFβ1 levels, and collagen I production. Low‐level blue light can be a potential treatment for the prevention and reduction of tissue fibrosis, such as hypertrophic scar and keloids. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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Electronic device generated light increases reactive oxygen species in human fibroblasts

Cited by 28 publications

References 26 publications

Hydroxytyrosol from olive fruits prevents blue‐light‐induced damage in human keratinocytes and fibroblasts

Hydroxytyrosol from olive fruits prevents blue‐light‐induced damage in human keratinocytes and fibroblasts

Beyond photoaging: additional factors involved in the process of skin aging

Proteomic Analysis Reveals Anti‐Fibrotic Effects of Blue Light Photobiomodulation on Fibroblasts

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