Electronic drug delivery systems: An overview

Vadlapatla, Rajesh; Wong, Eva; Gayakwad, Sanjaykumar G.

doi:10.1016/j.jddst.2017.08.008

Cited by 37 publications

(21 citation statements)

References 62 publications

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“…In that sense, the use of electronics brings a new approach for integration of data from multiple sources. IntelliCap ® is the world's first intelligent electronic drug delivery and monitoring device, which combines controlled drug release, patient monitoring, and real-time wireless communication [111,112]. Since this electronic capsule features real-time wireless data recording, it can provide care givers the ability to monitor the progress of the capsule through the GI tract.…”

Section: Electronic Device-assisted Formulation Designmentioning

confidence: 99%

“…Since this electronic capsule features real-time wireless data recording, it can provide care givers the ability to monitor the progress of the capsule through the GI tract. Furthermore, simultaneous measurement of pH and transit, along with accurately targeting drug delivery, makes in vivo data available for a formulation design [111,112]. Consequently, IntelliCap ® technology provides a fast and convenient tool for the controlled drug release to specific sites in the GI tract.…”

Section: Electronic Device-assisted Formulation Designmentioning

confidence: 99%

“…In addition to many benefits, there are also some disadvantages associated with electronic capsules including high cost, manufacturing difficulties, biocompatibility issues, and potential risk of device failure [111,112]. Hence, there should be continuous efforts to overcome these disadvantages in order to make electronic delivery systems more widely compatible.…”

Section: Electronic Device-assisted Formulation Designmentioning

confidence: 99%

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Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

et al. 2020

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Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to acidic and enzymatic degradation in the upper gastrointestinal tract. In recent years, the global pharmaceutical market for biologics has grown, and increasing demand for a more patient-friendly drug administration system highlights the importance of colonic drug delivery as a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules can provide therapeutic benefits including better patient compliance (because they are pain-free and can be self-administered) and lower costs. Therefore, to achieve more efficient colonic drug delivery for local or systemic drug effects, various strategies have been explored including pH-dependent systems, enzyme-triggered systems, receptor-mediated systems, and magnetically-driven systems. In this review, recent advancements in various approaches for designing colon targeted drug delivery systems and their pharmaceutical applications are covered with a particular emphasis on formulation technologies.

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Section: Electronic Device-assisted Formulation Designmentioning

confidence: 99%

Section: Electronic Device-assisted Formulation Designmentioning

confidence: 99%

Section: Electronic Device-assisted Formulation Designmentioning

confidence: 99%

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Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

et al. 2020

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“…For instance, connected diabetes management systems facilitate the capture of the dose and timing of administered insulin in electronic diaries [23], remind and encourage patients to monitor blood glucose levels [24], assist patients in calculating personalized prandial insulin doses [25,26], and interact with continuous glucose monitoring devices in order to seamlessly integrate insulin management [27,28]. In particular, research and practice has shown great interest in pursuing the development of connected and digitally enhanced drug delivery products [2,21,22,29]. Other chronic disease areas, such as psoriasis, hypercholesterolemia, or rheumatoid arthritis, where the point of care similarly shifts from the hospital to the home [4,30,31] will also likely benefit from the advanced patient support connected self-injection systems offer.…”

Section: Introductionmentioning

confidence: 99%

Toward a new age of patient centricity? The application of eye-tracking to the development of connected self-injection systems

Lohmeyer

Schneider

Jordi

et al. 2019

Expert Opinion on Drug Delivery

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Background: Increasing interest in digitally enhanced drug delivery tools urges both industry and academia to rethink current approaches to product usability testing. This article introduces mobile eyetracking, generating detailed contextual data about user engagement with connected self-injection systems as a new methodological approach to formative usability assessment. Methods: A longitudinal case study with a total of 35 injection-naïve participants was conducted. In three consecutive experiments, eye-tracking was applied to formative usability testing of a novel connected self-injection device. Three eye-tracking derived usability indicators were established to assess product effectiveness, efficiency, and ease of use. Results: Analysis of the data revealed events of user hesitation, process interruption and unintended action, and these occurrences could either be completely eliminated or significantly reduced throughout the process (product effectiveness). At the same time, the overall use duration decreased from 86.1 to 58.7 sec (product efficiency). Analysis revealed that product modifications successfully guided user attention to those interface elements most relevant during each task, thereby improving product easeof-use. Conclusions: The step-wise improvement in the usability indicators demonstrates that iteratively applying eye-tracking methods effectively supports the user-centered design of connected selfinjection systems. The results highlight how eye-tracking can be employed to gain an in-depth understanding of patient engagement with novel healthcare technologies. ARTICLE HISTORY

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“…Myriad applications could be developed using stimuli-responsive drug delivery systems, which can control the chronopharmacology of the therapeutic of interest in line with the chronobiology of the condition to be treated. A variety of different therapeutics have been delivered using electroresponsive conductive scaffolds, as previously reviewed [46,47]. Most of these systems relied on the use of conductive polymers (e.g., PPy, PANI and PEDOT) as the electroconductive/active moiety [46,47].…”

Section: Resultsmentioning

confidence: 99%

Electroresponsive Silk-Based Biohybrid Composites for Electrochemically Controlled Growth Factor Delivery

et al. 2020

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Stimuli-responsive materials are very attractive candidates for on-demand drug delivery applications. Precise control over therapeutic agents in a local area is particularly enticing to regulate the biological repair process and promote tissue regeneration. Macromolecular therapeutics are difficult to embed for delivery, and achieving controlled release over long-term periods, which is required for tissue repair and regeneration, is challenging. Biohybrid composites incorporating natural biopolymers and electroconductive/active moieties are emerging as functional materials to be used as coatings, implants or scaffolds in regenerative medicine. Here, we report the development of electroresponsive biohybrid composites based on Bombyx mori silkworm fibroin and reduced graphene oxide that are electrostatically loaded with a high-molecular-weight therapeutic (i.e., 26 kDa nerve growth factor-β (NGF-β)). NGF-β-loaded composite films were shown to control the release of the drug over a 10-day period in a pulsatile fashion upon the on/off application of an electrical stimulus. The results shown here pave the way for personalized and biologically responsive scaffolds, coatings and implantable devices to be used in neural tissue engineering applications, and could be translated to other electrically sensitive tissues as well.

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Electronic drug delivery systems: An overview

Cited by 37 publications

References 62 publications

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Toward a new age of patient centricity? The application of eye-tracking to the development of connected self-injection systems

Electroresponsive Silk-Based Biohybrid Composites for Electrochemically Controlled Growth Factor Delivery

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