“…Considerable resources have been allocated to improve patient safety since these reports on patient harm, with significant advances achieved in safety research, quality improvement initiatives, policy, health information technology, reimbursement strategies, and accreditation standards. 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 In certain clinical domains, such as hospital-acquired infections and transitions of care between teams and patient care units, there have been several reports suggesting notable nationwide improvements in outcomes. 11 , 12 , 13 It is unclear, however, if improvements in such proxy measures of overall patient safety have translated into mortality improvements across all types of adverse effects of medical treatment (AEMT) over time.…”