Objective: To develop and integrate a database system into the heterogeneous network environment of a dedicated radiosurgery treatment center with the goal to facilitate documentation, quality assurance, patient care, and scientific research. Methods: We customized a database on the basis of the commercial software FileMaker Pro® (FileMaker Inc., Santa Clara, CA). The multi-dimensional database system was fully integrated into the network infrastructure of the center. Automated data import and export was established utilizing programmed scripts. Specially trained medical assistants are in charge of the data management. Results: The database stores medical information prospectively and integrates all data of the radiosurgical process, from basic patient data to treatment parameters and follow-up information. All information is quickly available at any workplace in the center. Continuous adaptation of the data management to daily workflows ensures the accuracy and validity of the stored information. Automated scripts generate up-to-date reports and statistical analyses. Conclusions: The database enhances the quality of documentation, treatment, and patient care as well as comfort and efficiency in daily information workflows. To achieve this, the allocation of personnel with responsibility for the database system as well as the data management is crucial.