The main criterion for the sustainable development of social-andeconomic systems is the efficiency of functioning, taking into account the current environmental conditions. At the same time, favorable opportunities for carrying out activities, performing a certain role, confirming the significance in the future period are created. The analysis of the organization of enterprises’ innovation activities made it possible to establish the main trends in entrepreneurial behavior, to identify the features of innovation implementation, taking into account modern business conditions. As a result of the study, the authors found out the reasons for the low innovation activity at the enterprises in the Krasnoyarsk Territory, identified restrictions on the introduction of new technologies, the promotion of innovative products, the influence of factors on changes in the structure of financing innovations. Based on the opinions of specialists, the article highlights favorable opportunities for sustainable development of the region in the course of technological transformation, its resource provision, taking into account the increase in the innovation potential of organizations with the active assistance of the state to the innovation infrastructure development. The ongoing innovation processes determine environmentally oriented social changes leading to the development of society, contribute to increasing the innovations’ receptivity, the life quality and become the main tasks of sustainable development of the regional economy.