Electronmicroscopical investigations of the effects of heparin upon the structural elements of the rat glomerulus

Petorak, I.; Imren, Hüseyin Yılmaz; Iplikci, Altan

doi:10.1016/s0014-4908(77)80075-6

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A Hypothesis For Regulation Of Laminin Supramolecular Structure In Bm1

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1989

1990

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“…In short, intrinsic BM assembly and molecular architecture might be coordinately changed by a rise in concentration of a single extrinsic glycosaminoglycan. While heparin has been implicated in producing alterations of BM structure [Petorak et al,1977;Turley et al,1987] and function [Wardle & Uldall, 1972] no direct cause and effect has yet been established. The findings reported here raise the interesting possibility that such specific heparin mechanisms may exist and may be of biological importance.…”

Section: A Hypothesis For Regulation Of Laminin Supramolecular Structure In Bmmentioning

confidence: 99%