Electrooxidation of Indomethacin at Multiwalled Carbon Nanotubes-Modified GCE and Its Determination in Pharmaceutical Dosage Form and Human Biological Fluids

Abstract

A simple, rapid, selective, and sensitive electrochemical method for the direct determination of indomethacin was developed. The electrochemical behavior of indomethacin was carried at multiwalled carbon nanotube-(MWCNTs-) modified glassy carbon electrode (GCE). The cyclic voltammetric results indicated that MWCNT-modified glassy carbon electrode remarkably enhanced electrocatalytic activity towards the oxidation of indomethacin in slightly acidic solutions. It led to a considerable improvement of the anodic peak current for indomethacin and could effectively accumulate at this electrode and produce two anodic peaks at 0.720 V and 0.991 V, respectively, and one reduction peak at 0.183 V. The electrocatalytic behavior was further exploited as a sensitive detection scheme for the determination of indomethacin by differential-pulse voltammetry (DPV). Under optimized conditions, the concentration range and detection limit were 0.2 to 6.0 M and 13.2 nM, respectively. The proposed method was successfully applied to determination of Indomethacine in pharmaceutical samples. The analytical performance of this sensor has been evaluated for detection of analyte in human serum and urine as real samples.

CoAl2O4-Anchored Carbon Nanofiber Electrodes for Indomethacin Sensing in Water and Biological Samples

“…To study the electrochemical activity of CoAl 2 O 4 /f-CNF toward IDM, various studies have been performed using the CV technique. Figure (A) shows the CV curves of CoAl 2 O 4 /f-CNF and its control achieved by adding 250 μM IDM at a scan rate of 50 mV s –1 between a potential range of 0.65 and 1.05 V. The CV response of CoAl 2 O 4 /f-CNF/GCE indicates enhanced anodic peak current at 0.81 V than the controls and bare GCE due to the irreversible oxidation of the indolic group in IDM forming 2-(2-methyl-5-oxo-5 H -indol-3-yl) acetic acid with the elimination of two electrons and two protons (Figure S2). The moiety of indomethacin features a methoxy group affixed to the indole ring, serving as an electron-donating group susceptible to oxidation at the CoAl 2 O 4 /f-CNF-modified electrode surface.…”

“…C 0 is the concentration (mol cm −3 ), n is the number of electrons, D is the diffusion coefficient (cm 2 s −1 ), υ is the scan rate (mV s −1 ), and A is the electrochemical active surface area (cm 2 ). Using eq 1, the electrochemical active surface area of bare GCE, CoAl 2 O 4 /GCE, f-CNF/GCE, and CoAl 2 O 4 /f-CNF/ 46 (Figure S2). The moiety of indomethacin features a methoxy group affixed to the indole ring, serving as an electron-donating group susceptible to oxidation at the CoAl 2 O 4 /f-CNF-modified electrode surface.…”

Alternative methods of monitoring emerging contaminants in water: a review

“…Electrodes fabricated from nanomaterials such as multi-walled carbon nanotubes (MWCNTs), quantum dots, Au, Ag, Cu, Zn, Ni, graphite, and graphene oxide (GO) have gained much attention owing to their high effective surface area, good electrical conductivity, mechanical strength, striking structural orientation, and improved chemical stability. 23,24 However, using single nanomaterials to make electrochemical sensors has several drawbacks, including colloidal metal nanoparticles that are easy to reunify, quantum dot aggregation, graphene lamellar twisting, and difficult-to-achieve uniform dispersity. As a result, improving the conductivity, electron transfer kinetics, and electrocatalytic performance of the electrode catalyst with one or more nanomaterials (Fe-AuNPs and Ag-N-ZnO) co-doped in conjunction with composites (chitosan-AuNPs) has shown a positive response.…”

Development of a Novel Method for Quantitative Determination of Indomethacin

“…According to European pharmacopeia, which uses a titration method for the estimation of Indomethacin; absorption spectrophotometry is therefore used to determine the amount of the drug; also there are other different methods for the estimation including total leucocyte RESEARCH ARTICLE count (TLC), High-performance liquid chromatography (HPLC), Phosphomeric method, potentiometric, colorimetric *Author for Correspondence: kanaan_nehad.2016@uomustansiriyah.edu.iq, alialbakkaa@yahoo.com and phosphotungstic acid by continuing flow injection analysis via homemade ISNAG-fluorimeter. [7][8][9][10][11][12][13][14][15] Since the discovery of bis-(phen) cuprous complex as the first cuprous based chemical nuclease, many attempts have been made to study cuprous complexes of ligands in combination with quinolone family drugs as antitumor, antibacterial, antimicrobial, DNA intercalating, artificial nucleases and superoxide dismutase (SOD) mimic agents; Mineral-based medicine is a research area of increasing importance for inorganic chemistry and medicinal chemistry and has focused much attention as an approach to an expansion of activating new drugs. 11 If major pharmaceutical companies do not do extensive work in the area of mineral complexes, many developments will be lost.…”