Electrophoretic deposition of composite hydroxyapatite–chitosan–heparin coatings

Sun, Fangfang; Pang, Xin; Zhitomirsky, Igor

doi:10.1016/j.jmatprotec.2008.04.007

Cited by 101 publications

(53 citation statements)

References 51 publications

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“…2A. Interestingly, all three samples show a broad absorption in the range of 3300–3500 cm −1 which can be assigned to NH stretching absorption of heparin and hydrogen‐bonded hydroxyl groups of heparin and BC 26. Figure 2A(a) is the typical spectrum of heparin where a band at 1640 and 1236 cm −1 corresponds to CO and SO, respectively 17.…”

Section: Resultsmentioning

confidence: 94%

Biophysical Studies of the Amyloid β‐Peptide: Interactions with Metal Ions and Small Molecules

et al. 2013

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Alzheimer's disease is the most common of the protein misfolding ("amyloid") diseases. The deposits in the brains of afflicted patients contain as a major fraction an aggregated insoluble form of the so-called amyloid β-peptides (Aβ peptides): fragments of the amyloid precursor protein of 39-43 residues in length. This review focuses on biophysical studies of the Aβ peptides: that is, of the aggregation pathways and intermediates observed during aggregation, of the molecular structures observed along these pathways, and of the interactions of Aβ with Cu and Zn ions and with small molecules that modify the aggregation pathways. Particular emphasis is placed on studies based on high-resolution and solid-state NMR methods. Theoretical studies relating to the interactions are also included. An emerging picture is that of Aβ peptides in aqueous solution undergoing hydrophobic collapse together with identical partners. There then follows a relatively slow process leading to more ordered secondary and tertiary (quaternary) structures in the growing aggregates. These aggregates eventually assemble into elongated fibrils visible by electron microscopy. Small molecules or metal ions that interfere with the aggregation processes give rise to a variety of aggregation products that may be studied in vitro and considered in relation to observations in cell cultures or in vivo. Although the heterogeneous nature of the processes makes detailed structural studies difficult, knowledge and understanding of the underlying physical chemistry might provide a basis for future therapeutic strategies against the disease. A final part of the review deals with the interactions that may occur between the Aβ peptides and the prion protein, where the latter is involved in other protein misfolding diseases.

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Section: Resultsmentioning

confidence: 94%

Biophysical Studies of the Amyloid β‐Peptide: Interactions with Metal Ions and Small Molecules

et al. 2013

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“…A constant concentration of 0.5 g L 21 chitosan (prepared using 1 vol.% of acetic acid) was used according to the results reported by other authors. 46,47,53 TiO 2 concentration was varied from 0.5 to 10 g L 21 . In order to avoid hydrogen bubbles formation during the EPD process (due to water electrolysis) different ethanol-water ratios were considered.…”

Section: Methodsmentioning

confidence: 99%

Electrophoretic deposition of nanostructured-TiO2/chitosan composite coatings on stainless steel

et al. 2013

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Novel chitosan composite coatings containing titania nanoparticles (n-TiO 2 ) for biomedical applications were developed by electrophoretic deposition (EPD) from ethanol-water suspensions. The optimal ethanol-water ratio was studied in order to avoid bubble formation during the EPD process and to ensure homogeneous coatings. Different n-TiO 2 contents (0.5-10 g L 21) were studied for a fixed chitosan concentration (0.5 g L 21) and the properties of the electrophoretic coatings obtained were characterized.Coating composition was analyzed by thermogravimetric analysis (TG), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analysis. Scanning electron microscopy (SEM) was employed to study both the surface and the cross section morphology of the coatings, and the thicknesses (2-6 mm) of the obtained coatings were correlated with the initial ceramic content. Contact angle measurements, as a preliminary study to predict hypothetic protein attachment on the coatings, were performed for different samples and the influence of a second chitosan layer on top of the coatings was also tested. Finally, the electrochemical behavior of the coatings, evaluated by polarization curves in DMEM at 37 uC, was studied in order to assess the corrosion resistance provided by the n-TiO 2 /chitosan coatings.

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“…The electrodeposition [5,6] (or electrophoretic deposition [7,8]) of chitosan hydrogel onto conductive surfaces [9,10], normally achieved from aqueous solution under ambient conditions, is a convenient method to fabricate and localize this stimuli-responsive biomaterial [11]. A broad spectrum of applications ranging from the fabrication of composite films [8], and surface layer coatings [12,13] to biosensors [14] has been demonstrated based on this technique. Although we know that the electrical input induces a sol-gel transition of this stimuli-responsive polymer, there are still open questions and complications about the chitosan microstructure and deposition mechanism.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the cathodic electrodeposition of semicrystalline chitosan hydrogel

et al. 2012

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Electrophoretic deposition of composite hydroxyapatite–chitosan–heparin coatings

Cited by 101 publications

References 51 publications

Biophysical Studies of the Amyloid β‐Peptide: Interactions with Metal Ions and Small Molecules

Biophysical Studies of the Amyloid β‐Peptide: Interactions with Metal Ions and Small Molecules

Electrophoretic deposition of nanostructured-TiO2/chitosan composite coatings on stainless steel

Characterization of the cathodic electrodeposition of semicrystalline chitosan hydrogel

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