Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation

Bahners, Bahne Hendrik; Waterstraat, Gunnar; Kannenberg, Silja; Curio, Gabriel; Schnitzler, Alfons; Nikulin, Vadim V.; Florin, Esther

doi:10.1016/j.expneurol.2022.114031

Cited by 13 publications

(10 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For this, we first determined periods of significant communication, using parietal cortex – STN interactions as a baseline (Figure 3D). Estimates of motor cortex – STN communication were significant below 10 ms OFF therapy, timings in line with monosynaptic hyperdirect pathway transmission 33,35–37 (p < 0.05, cluster-corrected). Subsequent analysis of time delay estimates revealed a significant number of local peaks in the 1-9 ms window OFF therapy (p < 0.05; peak time 5.0±2.5 ms), indicative of communication during these times.…”

Section: Resultsmentioning

confidence: 53%

“…Estimates of motor cortex -STN communication were significant below 10 ms OFF therapy, timings in line with monosynaptic hyperdirect pathway transmission 33,[35][36][37] (p < 0.05, cluster-corrected).…”

Section: Cortico-subthalamic Time Delays Suggest Parallel Coupling Th...mentioning

confidence: 54%

“…Further support for a dopaminergic modulation of cortico-subthalamic communication comes from our observation that dopamine selectively suppresses the degree of information flow from cortex to STN in the 1-9 ms window associated with hyperdirect pathway activity 33,36,37 . In line with previous reports, we found no dopamine-specific effect on the net dominance of cortex in communication with STN, which may suggest that dopaminergic medication simultaneously reduces hyperdirect pathway signal transmission and the reciprocal communication with cortex.…”

Section: Dopamine and Dbs Modulate Directional Coupling And Latencies...mentioning

confidence: 73%

“…For the following analyses, we treated parietal cortex – STN interactions as a conservative physiological control where less communication is expected to secure the neuroanatomical specificity of our results. Pooled across the OFF therapy and ON levodopa conditions, the most robust time delay estimates occurred at 29.5±1.6 ms for motor cortex – STN communication, timings congruent with polysynaptic indirect pathway communication 33–35 . Significant differences in these delays were not observed between medication states (p > 0.05; 28.9±2.4 ms OFF therapy, 30.1±1.7 ms ON levodopa) or stimulation states (p > 0.05; 31.4±4.0 ms OFF therapy, 25.3±2.9 ms ON STN-DBS).…”

Section: Resultsmentioning

confidence: 91%

See 3 more Smart Citations

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

Binns,

Köhler,

Vanhoecke

et al. 2024

Preprint

View full text Add to dashboard Cite

Deep brain stimulation (DBS) is a brain circuit intervention that can modulate distinct neural pathways for the alleviation of neurological symptoms in patients with brain disorders. In Parkinson's disease, subthalamic DBS clinically mimics the effect of dopaminergic drug treatment, but the shared pathway mechanisms on cortex-basal ganglia networks are unknown. To address this critical knowledge gap, we combined fully-invasive neural multisite recordings in patients undergoing DBS surgery with MRI-based whole-brain connectomics. Our findings demonstrate that dopamine and DBS exert distinct mesoscale effects through modulation of local neural population synchrony. In contrast, at the macroscale, DBS mimics dopamine in its suppression of excessive interregional network synchrony associated with indirect and hyperdirect cortex-basal ganglia pathways. Our results provide a better understanding of the circuit mechanisms of dopamine and DBS, laying the foundation for advanced closed-loop neurostimulation therapies.

show abstract

Section: Resultsmentioning

confidence: 53%

Section: Cortico-subthalamic Time Delays Suggest Parallel Coupling Th...mentioning

confidence: 54%

Section: Dopamine and Dbs Modulate Directional Coupling And Latencies...mentioning

confidence: 73%

Section: Resultsmentioning

confidence: 91%

See 2 more Smart Citations

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

Binns,

Köhler,

Vanhoecke

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Phase–amplitude coupling has also been found in patients with freezing of gait [ 100 ]. A recent study illustrated cortical response features evoked by DBS that are closely related to the hyperdirect pathway through which STN receives input signals from cortical regions [ 101 ]. Another study used intraoperative H-reflex measurement as a potential biomarker for optimal electrode positioning [ 102 ].…”

Section: Closed-loop Deep Brain–machine Interfacementioning

confidence: 99%

Deep brain–machine interfaces: sensing and modulating the human deep brain

Sui

Zhang

et al. 2022

National Science Review

View full text Add to dashboard Cite

Different from the conventional brain machine interfaces which focus more on decoding cerebral cortex, deep brain machine interfaces enable interactions between external machines and deep brain structures. They sense and modulate deep brain neural activities, aiming at function restoration, device control and therapeutic improvements. In this article, we provide an overview of multiple deep brain recording and stimulation techniques which can serve as deep brain machine interfaces. We highlight two widely used interface technologies, deep brain stimulation and stereotactic electroencephalography, for technical trends, clinical applications and brain connectivity research. We discuss the potential to develop closed-loop deep brain machine interfaces and achieve more effective and applicable systems for the treatment of neurological and psychiatric disorders.

show abstract

The effect of subthalamic nucleus deep brain stimulation on speech performance: a prospective clinical and tractography study

Hasimoglu,

Altinkaya,

Tuysuz

et al. 2024

Acta Neurochir

View full text Add to dashboard Cite

Electrophysiological characterization of the hyperdirect pathway and its functional relevance for subthalamic deep brain stimulation

Cited by 13 publications

References 96 publications

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

Deep brain–machine interfaces: sensing and modulating the human deep brain

The effect of subthalamic nucleus deep brain stimulation on speech performance: a prospective clinical and tractography study

Contact Info

Product

Resources

About