Electrophysiological Effects of Allopregnanolone in Rats With a History of Ethanol Exposure

Abstract

These data indicate that a history of EtOH exposure attenuates some of the neurophysiological effects of ALLO in a manner consistent with cross-tolerance. Taken together, these data suggest that increased sensitivity to ALLO's neurobehavioral effects is limited to the early phases of EtOH withdrawal and may not extend to more protracted periods of abstinence.

Two-choice reaction time performance in Sprague–Dawley rats exposed to alcohol during adolescence or adulthood

“…At present, the mechanisms that might account for increased accuracy following ethanol exposure are unclear. It has been reported that a history of ethanol exposure can produce perseverative behavior (Abel, 1982;Vigliecca et al, 1989;Obernier et al, 2002) and induce enhanced central nervous system arousal levels (Begleiter and Porjesz, 1977;Ehlers and Chaplin, 1991;Slawecki et al, 2005b). As such, it could be speculated that accuracy was increased because a mild perseverative profile and/or augmented central nervous system arousal levels helped keep ethanol-exposed rats engaged and attentive during the 2-CRT task.…”

Remission and Resurgence of Anxiety‐Like Behavior Across Protracted Withdrawal Stages in Ethanol‐Dependent Rats

“…After termination of ethanol vapor exposure, the rats were returned to the vivarium, where they remained until testing. Such ethanol dependence‐inducing procedures have been utilized by ourselves and other groups, leading to neuroadaptation in stress‐regulatory systems (e.g., Funk et al., 2007; Rimondini et al., 2005; Sabino et al., 2006; Slawecki et al., 2005, 1999).…”

Electrophysiological Effects of Dizocilpine (MK‐801) in Adult Rats Exposed to Ethanol During Adolescence

“…ERP components were identified on the basis of the largest amplitude peak within a specified latency range. Latency windows (in milliseconds) were used to identify ERP components (P1, N1, and P3) for the frontal cortex, parietal cortex and hippocampus, as previously described (Slawecki et al., 2001, 2005). The prestimulus baseline consisted of EEG activity during the 100 milliseconds before stimulus onset.…”