Electrophysiological effects of non-invasive Radio Electric Asymmetric Conveyor (REAC) on thalamocortical neural activities and perturbed experimental conditions

Abstract

The microwave emitting Radio Electric Asymmetric Conveyor (REAC) is a technology able to interact with biological tissues at low emission intensity (2 mW at the emitter and 2.4 or 5.8 GHz) by inducing radiofrequency generated microcurrents. It shows remarkable biological effects at many scales from gene modulations up to functional global remodeling even in human subjects. Previous REAC experiments by functional Magnetic Resonance Imaging (fMRI) on healthy human subjects have shown deep modulations of cortical BOLD signals. In this paper we studied the effects of REAC application on spontaneous and evoked neuronal activities simultaneously recorded by microelectrode matrices from the somatosensory thalamo-cortical axis in control and chronic pain experimental animal models. We analyzed the spontaneous spiking activity and the Local Field Potentials (LFPs) before and after REAC applied with a different protocol. The single neuron spiking activities, the neuronal responses to peripheral light mechanical stimuli, the population discharge synchronies as well as the correlations and the network dynamic connectivity characteristics have been analyzed. Modulations of the neuronal frequency associated with changes of functional correlations and significant LFP temporal realignments have been diffusely observed. Analyses by topological methods have shown changes in functional connectivity with significant modifications of the network features.

REAC-induced endogenous bioelectric currents in the treatment of venous ulcers: a three-arm randomized controlled prospective study

“…Patients in Group A experienced more rapid disappearance of pain, followed by Group B, and finally Group C. This suggests that REAC TO-RPR treatment, in combination with dressing and elastic compression, is more effective in reducing the components that aggravate the pain in patients with venous ulcers. In fact, previous studies on the use of REAC technology have proven its ability to modulate neuronal circuits of pain (26).…”

Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

“…REAC devices use only two frequencies (2.4 and 5.8 GHz), the most widely-used and permitted at the international level. Based on our clinical and scientific experience, 2.4 GHz was chosen because it better interacts with tissues, cell cultures, and the nervous system [13,33,34].…”

REAC Non-invasive Neurobiological Stimulation for Mitigating the Impact of Internalizing Disorders in Autism Spectrum Disorder

“…The REAC technology has not a main target brain region for stimulation because it is able to globally reorganize the level of synaptic activities and the related neural circuitry dynamics in the brain (Zippo et al, 2015), not eliciting specific inhibitory or excitatory stimulations, but optimizing EBA and rearranging neural dynamics within "opportune" ranges when altered.…”