REAC-induced endogenous bioelectric currents in the treatment of venous ulcers: a three-arm randomized controlled prospective study

Abstract

Introduction: Endogenous bioelectric fields (EBFs) play a fundamental role in promoting repair and regeneration processes, including in leg venous ulcers (LVUs). Unfortunately, the mechanism underlying the production of EBFs is easily altered by infectious, traumatic, and epigenetic factors. This alteration is one of the determining factors for the chronicity of LVUs. This study investigates how radioelectric asymmetric conveyer (REAC) technology treatments, specifically designed to optimize EBFs, and in particular tissue optimization-reparative (TO-RPR) treatment, can improve the results of standard dressing with and without elastic compression in LVU patients. Methods: A total of 30 patients were enrolled (12 males and 18 females) and randomized into three groups. All patients completed the study. Group A was treated with standard dressing, elastic compression, and REAC TO-RPR treatment; Group B was treated with standard dressing and REAC TO-RPR treatment; and Group C was treated with standard dressing and elastic compression. Results:The results show that the combination of REAC treatment and standard dressing associated with elastic compression has the greatest therapeutic efficacy in promoting the healing process for ulcers, reducing perceived pain, and improving the quality of life of the patients treated. Conclusions: Further studies will be useful to investigate these prospective results.

The Reparative Effects of Radio Electric Asymmetric Conveyer Technology on Facial Injuries: A Report of Two Cases

“…It is interesting to highlight that the reparative effects induced by the REAC TO-RPR treatment prevented the formation of scarring, and this finding has already been demonstrated by other previously published studies [1][2][3].…”

“…Hence, it is important to employ therapeutic approaches that can promote the therapeutic processes of repairing the injured tissues, thereby preventing outcomes that can disfigure the aesthetics of the face. Nowadays, one of the therapeutic tools used to treat this type of injury is the noninvasive treatment of reparative tissue optimization (TO-RPR) [1][2][3], which is enabled by the radio electric asymmetric conveyer (REAC) technology for neurobiological stimulation treatments. In this report, we discuss our experience with two cases of facial trauma from bicycle accidents.…”

Radio Electric Asymmetric Conveyer Tissue Reparative Treatment on Post-surgical Breast Skin Necrosis. A Report of Four Cases

“…The REAC functional recovery of the correct EBA is able to promote reparative [ 11 , 14 , 15 ] and regenerative processes [ 16 - 18 ], up to determining phenomena of direct cellular reprogramming [ 12 , 13 , 19 , 20 ]. The possibility of obtaining refined reparative processes in a short time is particularly useful when it is desirable to achieve results that are also aesthetically pleasing, such as in the cases reported in this manuscript.…”

Venous Leg Ulcers: Advanced Therapies and New Technologies

“…Galvanotaxis inhibitors, such as infectious or epigenetic agents, can disrupt an electric charge flow that localizes at the wound and inhibits regenerative processes. Various, exogenous forms of electrotherapy are used so as to stimulate regenerative processes in VLUs by imitating this physiological phenomenon [ 22 , 23 ].…”

“…Unfortunately, nowadays it is not possible to indicate the most efficient sort of ES owing to variability in the study protocols and lack of comparable, head-to-head clinical studies. Nevertheless, PC in contrast to AC, has polarity, can better imitate the physiological current, and penetrate deeply into the skin [ 22 , 23 ].…”