Electrophysiological Evidence That the Retrosplenial Cortex Displays a Strong and Specific Activation Phased with Hippocampal Theta during Paradoxical (REM) Sleep

Koike, Bruna Del Vechio; Farias, Kelly Soares; Billwiller, Francesca; Almeida-Filho, Daniel G.; Libourel, Paul-Antoine; Tiran-Cappello, Alix; Parmentier, Régis; Blanco, Wilfredo; Ribeiro, Sidarta; Luppi, Pierre‐Hervé; Queiroz, Cláudio Marcos Teixeira de

doi:10.1523/jneurosci.0026-17.2017

Cited by 63 publications

(68 citation statements)

References 37 publications

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“…Considering the effects that we had established in the theta frequency band, we next examined gamma and higher frequency oscillations (HFO; >100 Hz). Looking at coupling between the phase of theta and the amplitude of gamma oscillations we first established that, consistent with results of Belluscio et al (2012) and Koike et al (2017), gamma oscillations are consistently dominant on the descending slope of the theta cycle while RSC gamma is dominant closer to the theta peak ( Fig. 2H).…”

Section: Mammillothalamic Tract Lesions Attenuate Hippocampal Theta Fsupporting

confidence: 83%

“…3G). Given the peak frequencies of HFO during PS was considerably lower than during locomotion, these changes are likely to reflect the induced hyperactivity of separate subpopulations of the RSC that are specifically active during either PS (68% of RSC units reported by Koike et al, 2017) or during locomotion. Unlike in awake animals, however, no effect was seen in waveform dynamics of the theta cycle, leaving open an explanation for the PS-associated hyperactivity (in both HPC (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…During PS, RSC theta phase is strongly coupled to the amplitude of fast gamma/HFO (80-150 Hz) amplitude (Koike et al, 2017;Fig. 4J), with weaker phase amplitude coupling in HPC.…”

Section: Mammillothalamic Tract Lesions Attenuate Theta Frequency Durmentioning

confidence: 99%

“…In the RSC, the amplitude of gamma oscillations/HFO (30-150 Hz) is strongly coupled with the descending phase of the theta cycle during PS (Belluscio et al, 2012;Koike et al, 2017). First, to determine whether the phase (within the theta cycle) in which fast gamma was dominant was affected by disconnection of the mammillary bodies, we calculated the time lag between the trough of gamma oscillations (of power > 2 standard deviations of the baseline), and the peak of the synchronous theta cycle.…”

Section: Mammillothalamic Tract Lesions Attenuate Theta Frequency Durmentioning

confidence: 99%

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Mammillothalamic disconnection alters hippocampo-cortical oscillatory activity and microstructure: Implications for diencephalic amnesia

Dillingham

Milczarek²,

Perry³

et al. 2019

Preprint

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for technical, histological and surgical assistance. AbstractDiencephalic amnesia can be as disruptive as the more commonly known temporal lobe amnesia, yet the precise contribution of diencephalic structures to memory processes remains elusive. We used discrete lesions of the mammillothalamic tract to model aspects of diencephalic amnesia and assessed the impact of these lesions on multiple measures of activity and plasticity within the hippocampus and retrosplenial cortex. Lesions of the mammillothalamic tract had widespread indirect effects on hippocampo-cortical oscillatory activity within both theta and gamma bands. Both within-region oscillatory activity and cross-regional synchrony were altered. The network changes were state-dependent, displaying different profiles during locomotion and paradoxical sleep. Consistent with the associations between oscillatory activity and plasticity, complementary analyses using several convergent approaches revealed microstructural changes, which appeared to reflect a suppression of learning-induced plasticity in lesioned animals. Together, these combined findings suggest a mechanism by which damage to the medial diencephalon can impact upon learning and memory processes, highlighting important role for the mammillary bodies in the co-ordination of hippocampo-cortical activity.

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Section: Mammillothalamic Tract Lesions Attenuate Hippocampal Theta Fsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

“…During PS, RSC theta phase is strongly coupled to the amplitude of fast gamma/HFO (80-150 Hz) amplitude (Koike et al, 2017;Fig. 4J), with weaker phase amplitude coupling in HPC.…”

Section: Mammillothalamic Tract Lesions Attenuate Theta Frequency Durmentioning

confidence: 99%

Section: Mammillothalamic Tract Lesions Attenuate Theta Frequency Durmentioning

confidence: 99%

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Mammillothalamic disconnection alters hippocampo-cortical oscillatory activity and microstructure: Implications for diencephalic amnesia

Dillingham

Milczarek²,

Perry³

et al. 2019

Preprint

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“…In building off of geometry detection in RSC EBC ensembles, a natural next question is how might these egocentric positional signals be integrated within the broader spatial circuity. Previous work has demonstrated that RSC local field potentials feature a prominent theta oscillation during active movement that is strongly coherent with theta rhythms observed in the dorsal hippocampal formation (Borst et al, 1987; Colom et al, 1988; Talk et al, 2004; Koike et al, 2017; Alexander et al, 2018). Spatial representations in regions with strong theta rhythmicity, such as MEC or HPC, are strongly influenced by boundaries and environmental geometry (Muller and Kubie, 1987; Gothard et al, 1996; O’Keefe and Burgess, 1996; Kenaith et al, 2017; Kinsky et al, 2018; Solstadt et al, 2008; Krupic et al, 2015; Krupic et al, 2018).…”

Section: Resultsmentioning

confidence: 68%

Egocentric boundary vector tuning of the retrosplenial cortex

Alexander

Carstensen

Hinman

et al. 2019

Preprint

121

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31The retrosplenial cortex is reciprocally connected with a majority of structures implicated in 32 spatial cognition and damage to the region itself produces numerous spatial impairments. 33However, in many ways the retrosplenial cortex remains understudied. Here, we sought to 34 characterize spatial correlates of neurons within the region during free exploration in two-35 dimensional environments. We report that a large percentage of retrosplenial cortex neurons 36 have spatial receptive fields that are active when environmental boundaries are positioned at a 37 specific orientation and distance relative to the animal itself. We demonstrate that this vector-38 based location signal is encoded in egocentric coordinates, localized to the dysgranular 39 retrosplenial sub-region, independent of self-motion, and context invariant. Further, we identify a 40 sub-population of neurons with this response property that are synchronized with the 41 hippocampal theta oscillation. Accordingly, the current work identifies a robust egocentric spatial 42 code in retrosplenial cortex that can facilitate spatial coordinate system transformations and 43 support the anchoring, generation, and utilization of allocentric representations. 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 108 From a connectivity standpoint, the retrosplenial cortex (RSC) is an excellent candidate to 109 examine egocentric representations during navigation. Further, theoretical work has posited that 110 RSC forms a computational hub for supporting coordinate transformations (Byrne et al., 2007;111 Clark et al., 2018; Rounds et al., 2018; Bicankski and Burgess, 2018). RSC is composed of two 112 interconnected sub-regions, dysgranular (dRSC) and granular (gRSC), which have slightly 113 different connectivity with cortical and subcortical regions (Shibata et al., 2009). dRSC (in mice 114 agranular RSC) is positioned along the dorsal surface of the brain and possesses biased 115 interconnectivity with association, sensory, and motor processing regions that code in 116

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Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus

et al. 2023

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This paper reviews the recent experimental finding that neurons in behaving rodents show egocentric coding of the environment in a number of structures associated with the hippocampus. Many animals generating behavior on the basis of sensory input must deal with the transformation of coordinates from the egocentric position of sensory input relative to the animal, into an allocentric framework concerning the position of multiple goals and objects relative to each other in the environment. Neurons in retrosplenial cortex show egocentric coding of the position of boundaries in relation to an animal. These neuronal responses are discussed in relation to existing models of the transformation from egocentric to allocentric coordinates using gain fields and a new model proposing transformations of phase coding that differ from current models. The same type of transformations could allow hierarchical representations of complex scenes. The responses in rodents are also discussed in comparison to work on coordinate transformations in humans and non-human primates.

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Electrophysiological Evidence That the Retrosplenial Cortex Displays a Strong and Specific Activation Phased with Hippocampal Theta during Paradoxical (REM) Sleep

Cited by 63 publications

References 37 publications

Mammillothalamic disconnection alters hippocampo-cortical oscillatory activity and microstructure: Implications for diencephalic amnesia

Mammillothalamic disconnection alters hippocampo-cortical oscillatory activity and microstructure: Implications for diencephalic amnesia

Egocentric boundary vector tuning of the retrosplenial cortex

Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus

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