Electrophysiology of ventromedial striatal neurons during movement

Patino, P.; García‐Muñoz, Marianela; Freed, Curt R.

doi:10.1016/0361-9230(95)00028-d

Cited by 8 publications

(7 citation statements)

References 27 publications

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“…As shown for representative responses in Figure 3A-D, CNQX and AP5 dose-dependently reversed both spontaneous and GLU-evoked activity. Also note that, consistent with previous reports (Kiyatkin and Rebec, 1999;Patino et al, 1995;West et al, 1987), frank excitations occurred in conjunction with spontaneous movement (Fig. 3C,D), but the brief and sporadic nature of such movement precluded iontophoretic testing.…”

Section: Effects Of Glu Receptor Antagonistssupporting

confidence: 90%

“…Consistent with these findings, the relatively few studies of GLU effects in conscious, unrestrained animals have shown that GLU application excites spontaneously active neurons and activates so-called silent cells Rebec, 1996, 1999;Pierce and Rebec, 1995). In these animals, behavioral activation alone, which presumably reflects increased GLU drive from cortical afferents (Brown et al, 1997;Wilson, 1998), is a strong activator of striatal neurons Patino et al, 1995;Rebec, 1992;Woodward, 1999). No information is available, however, on the relative numbers of spontaneously active and silent units under naturally occurring physiological conditions.…”

Section: Introductionmentioning

confidence: 65%

“…Finally, although striatal recordings were taken from a fairly circumscribed region of the mediolateral axis, there is no reason to presume activity levels obtained from alternative mediolateral positions would be dramatically different. This is particularly true of animals recorded during quiet rest, because different activity levels would be expected during specific behaviors (see Mittler et al, 1994;Patino et al, 1995). If anything, a priori assumptions based on available data suggest action potential frequency is fairly homogeneous across the entire anterior striatum (Wilson, 1998).…”

Section: Spontaneously Active Neuronsmentioning

confidence: 99%

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Characterization of striatal activity in conscious rats: Contribution of NMDA and AMPA/kainate receptors to both spontaneous and glutamate‐driven firing

Sandstrom

Rebec

2002

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Single-unit activity in the striatum of unrestrained, conscious rats was characterized by extracellular recording in combination with iontophoresis. To avoid the confounding effect of motor-related changes in firing rate, measurements were restricted to periods when animals were at quiet rest. Recording electrodes were lowered stepwise through 4.0 mm of anterior striatum in 36 equal ventral movements of 111 microm to assess the ratio of spontaneously active vs. silent neurons. Spontaneous activity was assessed at each step followed by iontophoretic glutamate (GLU) application to expose silent neurons. Eleven such experimental sessions resulted in a total of 100 spontaneously active and 264 silent neurons, indicating that without overt movement the large majority (72.7%) of striatal cells are silent. Spontaneously active neurons, moreover, discharged at low rates (4.85 +/- 0.85 spikes/s). In separate experiments, both the AMPA/kainate (CNQX: 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline disodium salt) and NMDA (AP5: D-(-)-2-amino-5-phosphonovaleric acid) GLU-receptor antagonists blocked the activity of most spontaneously active (83% CNQX, 69% AP5), and GLU-stimulated silent (68% CNQX, 98% AP5) units. Collectively, our results are consistent with an overall low level of striatal activity in the absence of strong excitatory input. When neuronal activity is initiated, however, it appears that both NMDA and AMPA/kainate receptors are critical for maintaining continuous impulse activity.

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Section: Effects Of Glu Receptor Antagonistssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 65%

Section: Spontaneously Active Neuronsmentioning

confidence: 99%

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Characterization of striatal activity in conscious rats: Contribution of NMDA and AMPA/kainate receptors to both spontaneous and glutamate‐driven firing

Sandstrom

Rebec

2002

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“…On the basis of sound neuropharmacological evidence it is assumed that both schizophrenic delusions and left-sided body turns are a direct consequence of a hemi-hyperdopaminergia of the right cerebral hemisphere (Bracha, 1989). Similarly, Parkinsonian patients with an asymmetric hemispheric dopamine depletion were shown to preferably rotate towards the more affected hemisphere during unconstrained long-term locomotion (Bracha, Seitz, Otemaa, & Glick, 1987;Patino, Garcia-Munoz, & Freed, 1995). Asymmetric locomotion is also observed after unihemispheric stroke.…”

Section: Introductionmentioning

confidence: 99%

Measurement of human rotation behavior for psychological and neuropsychological investigations

et al. 2015

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The investigation of rotation behavior in human beings enjoys a longstanding and enduring interest in laterality research. While in animal studies the issue of accurately measuring the number of rotations has been solved and is widely applied in practice, it is still challenging to assess the rotation behavior of humans in daily life. We propose a robust method to assess human rotation behavior based on recordings from a miniature inertial measurement unit that can be worn unobtrusively on a belt. We investigate the effect of different combinations of low-cost sensors-including accelerometers, gyroscopes, and magnetometers-on rotation measurement accuracy, propose a simple calibration procedure, and validate the method on data from a predefined path through and around buildings. Results suggest that a rotation estimation based on the fusion of accelerometer, gyroscope, and magnetometer measurements outperforms methods based solely on earth magnetic field measurements, as proposed in previous studies, by a drop in error rate of up to 32 %. We further show that magnetometer signals do not significantly contribute to measurement accuracy in short-term measurements, and could thus be omitted for improved robustness in environments with magnetic field disturbances. Results also suggest that our simple calibration procedure can compete with more complex approaches and reduce the error rate of the proposed algorithm by up to 38 %. The investigation of rotation behavior in human beings enjoys a longstanding and enduring interest in laterality research. While, in animal studies, the issue of accurately measuring the number of rotations has been solved and is widely applied in practice, it is still challenging to assess the rotation behavior of humans in daily life. We propose a robust method to assess human rotation behavior based on recordings from a miniature inertial measurement unit that can be worn unobtrusively on a belt. We investigate the effect of different combinations of low-cost sensors -including accelerometers, gyroscopes and magnetometers -on rotation measurement accuracy, propose a simple calibration procedure, and validate the method on data from a predefined path through and around buildings. Results suggest that a rotation estimation based on the fusion of accelerometer, gyroscope and magnetometer measurements outperforms methods based solely on earth magnetic field measurements, as proposed in previous studies, by a drop in error rate of up to 32%. We further show that magnetometer signals do not significantly contribute to measurement accuracy in short-term measurements, and could thus be omitted for improved robustness in environments with magnetic field disturbances. Results also suggest that our simple calibration procedure can compete with more complex approaches and reduces the error rate of the proposed algorithm by up to 38%.

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“…Η προτίμηση για δεξιόστροφη ή αριστερόστροφη περιστροφή έχει αποδειχθεί πως αποτελεί λειτουργία των μεσεγκεφαλικών συστημάτων ντοπαμίνης, ειδικότερα της προβολής του νεοραβδωτού (Pycock, 1980) και καθορίζεται από την ασύμμετρη ντοπαμινεργική δραστηριότητα μεταξύ δεξιού και αριστερού βασικού γαγγλίου ή προσθιοπλάγιου φλοιού (Lemoal & Simon, 1991). Έχει παρατηρηθεί πως το εγκεφαλικό ημισφαίριο που συγκεντρώνει τα υψηλότερα ποσοστά ντοπαμίνης είναι ετερόπλευρο της προτιμώμενης πλευράς περιστροφής (Gordon, et al, 1992;Patino, Garciamunoz, & Freed, 1995). Η σχέση μεταξύ του ποσοστού συγκέντρωσης της ντοπαμίνης στα εγκεφαλικά ημισφαίρια και της πλευρά προτίμησης περιστροφής έχει εδραιωθεί http://epublishing.ekt.gr | e-Publisher: EKT | Downloaded at 07/06/2019 00:52:35 | σημαντικά, έτσι ώστε χωρίς μετρήσιμα στοιχεία της ντοπαμινεργιακής ασυμμετρίας, η πλευρά προτίμησης περιστροφής αποτελεί σημαντική ένδειξη της (Brunner & Gattaz, 1995;Lindemann, Lessenich, Ebert, & Loscher, 2001).…”

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Περιστροφική Κίνηση Με Δοκιμασίες Προτίμησης Και Επίδοσης Σε Δεξιόχειρα Και Μη Δεξιόχειρα Παιδιά Χρονικής Ηλικίας Τριών Έως Έξι Ετών

Πέτρου¹,

Γρούιος²

2016

edusc

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Περιστροφική κίνηση με δοκιμασίες προτίμησης και επίδοσης σε δεξιόχειρα και μη δεξιόχειρα παιδιά χρονικής ηλικίας τριών έως έξι ετών Πέτρου Μικαέλα Γρούιος Γεώργιος http://dx.doi.org/10.12681/edusc.364 Copyright © 2015 Πανελλήνιο Συνέδριο Επιστημών Εκπαίδευσης To cite this article: Πέτρου, & Γρούιος (2015). Περιστροφική κίνηση με δοκιμασίες προτίμησης και επίδοσης σε δεξιόχειρα και μη δεξιόχειρα παιδιά χρονικής ηλικίας τριών έως έξι ετών. Πανελλήνιο Συνέδριο Επιστημών Εκπαίδευσης, 2015, 1226-1242. ggrouios@phed.auth.gr Περίληψη Τα ανθρώπινα εγκεφαλικά ημισφαίρια παρουσιάζουν αισθητηριακές, γνωστικές και κινητικές ασυμμετρίες. Η περιστροφική κίνηση αποτελεί τύπο κινητικής ασυμμετρίας και ορίζεται ως η αυθόρμητη τάση περιστροφής προς τη δεξιά ή την αριστερή πλευρά. Η μελέτη σχεδιάστηκε για τη διερεύνηση της περιστροφικής συμπεριφοράς, δεξιόχειρων και μη δεξιόχειρων παιδιών, χρονικής ηλικίας τριών έως έξι ετών, μέσω της συμμετοχής τους σε δοκιμασίες προτίμησης και επίδοσης περιστροφής. Το δείγμα (Ν=51) παιδιά προσχολικής αγωγής, κατανεμήθηκαν στην Α' (n=22, 38-49 μηνών), Β' (n=19, 50-61 μηνών) και Γ' ομάδα (n=10, 63-74 μηνών). Για κάθε συμμετέχοντα, συμπληρώθηκε το ερωτηματολόγιο προτίμησης άνω άκρου, το διάγραμμά εκτέλεσης περιστροφής (Ε.Π.) και το διάγραμμα της απεικονιστικής αναπαράστασης (Α.Α.) της περιστροφής. Στα αποτελέσματα, παρατηρήθηκαν όμοια ποσοστά περιστροφής για την Α' ομάδα στην Ε.Π. του 1 ου , 3 ου και 4 ου έργου, για τη Β' ομάδα στην Ε.Π. του 1 ου και 3 ου έργου και στην Α.Α. του 2 ου , 3 ου και 4 ου έργου. Τόσο τα δεξιόχειρα όσο και τα μη δεξιόχειρα παιδιά του δείγματος επέδειξαν στην πλειοψηφία τους υψηλοτέρα ποσοστά δεξιόστροφης περιστροφής. Τα αποτελέσματα της μελέτης συζητούνται υπό το φως των σύγχρονων θεωρητικών δεδομένων που αφορούν τα ψυχοβιολογικά χαρακτηριστικά της περιστροφικής συμπεριφοράς του ανθρώπου.Λέξεις κλειδιά: περιστροφική κίνηση, πλευρά προτίμησης περιστροφής, πλευρίωση, προτίμηση άνω άκρου, ασυμμετρία, παιδιά. AbstractHuman cerebral hemispheres show sensory, cognitive and motor asymmetries. Rotational behavior is a type of motor asymmetry and is defined as the spontaneous tendency of rotation to the right or left side. The purpose of this thesis was to investigate the circling behavior of right-handed and non-right-handed children aged from three to six years old, by participating in preferred and performance tasks. The participants (N=51) preschool children, were divided into the A' (n = 22, 38-49 months), B' (n = 19, 50-61 months) and C' group (n = 10, 63-74 months). For each participant was completed the handedness questionnaire, the performance (Per.T.) and the preference tasks (Pre.T.) of rotation. The results showed that similar rates of rotation were observed to A group in the 1 st , 3 rd and 4 th Per.T., to B group in the 1 st and 3 rd Per.T. also in 2 nd , 3 rd and 4 th Pre.T. Right and non-right handed children showed higher rates of right rotational behavior. These findings contribute to the psychobiological characteristics of human rotational behavior.http://...

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Electrophysiology of ventromedial striatal neurons during movement

Cited by 8 publications

References 27 publications

Characterization of striatal activity in conscious rats: Contribution of NMDA and AMPA/kainate receptors to both spontaneous and glutamate‐driven firing

Characterization of striatal activity in conscious rats: Contribution of NMDA and AMPA/kainate receptors to both spontaneous and glutamate‐driven firing

Measurement of human rotation behavior for psychological and neuropsychological investigations

Περιστροφική Κίνηση Με Δοκιμασίες Προτίμησης Και Επίδοσης Σε Δεξιόχειρα Και Μη Δεξιόχειρα Παιδιά Χρονικής Ηλικίας Τριών Έως Έξι Ετών

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